Antihypertensive effects of Ocimum basilicum L. (OBL) on blood pressure in renovascular hypertensive rats

Hypertension Research

Volumn 33, Issue 7, 2010, Pages 727-730

  Umar, Anwar ^a,b   Imam, Guzelnur ^a   Yimin, Wuliya ^a   Kerim, Parhat ^a   Tohti, Ibadet ^a   Berké, Bénédicte ^b   Moore, Nicholas ^a,b  

^a XINJIANG MEDICAL UNIVERSITY   (China)

^b UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

2K1C experimental hypertension; angiotensin II; endothelin 1; left ventricular hypertrophy; Ocimum basilicum

Indexed keywords

ANGIOTENSIN II; CAPTOPRIL; CREATININE; ENDOTHELIN 1; NITROGEN; OCIMUM BASILICUM EXTRACT; UREA; ANTIHYPERTENSIVE AGENT; ASPARTIC PROTEINASE; ENDOTHELIN-CONVERTING ENZYME; METALLOPROTEINASE; PLANT EXTRACT;

ANGIOTENSIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; BODY WEIGHT; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; DISEASE MODEL; DRUG MEGADOSE; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; LOW DRUG DOSE; MALE; NONHUMAN; PLANT LEAF; PLANT STEM; RAT; RENOVASCULAR HYPERTENSION; SYSTOLIC BLOOD PRESSURE; UREA NITROGEN BLOOD LEVEL; ANIMAL; ANTAGONISTS AND INHIBITORS; BASIL; BLOOD; BLOOD PRESSURE; CARDIOMEGALY; DRUG EFFECTS; HYPERTENSION, RENOVASCULAR; KIDNEY; PHYSIOLOGY; WISTAR RAT;

ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; ASPARTIC ACID ENDOPEPTIDASES; BLOOD PRESSURE; CAPTOPRIL; CARDIOMEGALY; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; HYPERTENSION, RENOVASCULAR; KIDNEY; MALE; METALLOENDOPEPTIDASES; OCIMUM BASILICUM; PLANT EXTRACTS; RATS; RATS, WISTAR;

EID: 77954381277     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2010.64     Document Type: Article

References (18)

1. Tohti I, Tursun M, Umar A, Turdi S, Imin H, Moore N. Aqueous extracts of Ocimum basilicum L. (sweet basil) decrease platelet aggregation induced by ADP and thrombin in vitro and rats arterio\venous shunt thrombosis in vivo. Thromb Res 2006; 118: 733-739.
2. Amrani S, Harnafi H, Bouanani Nel H, Aziz M, Caid HS, Manfredini S, Besco E, Napolitano M, Bravo E. Hypolipidaemic activity of aqueous Ocimum basilicum extract in acute hyperlipidaemia induced by triton WR-1339 in rats and its antioxidant property. Phytother Res 2006; 20: 1040-1045.
3. Bravo E, Amrani S, Aziz M, Harnafi H, Napolitano M. Ocimum basilicum ethanolic extract decreases cholesterol synthesis and lipid accumulation in human macrophages. Fitoterapia 2008; 79: 515-523.
4. Kaminska M, Mogielnicki A, Stankiewicz A, Kramkowski K, Domaniewski T, Buczko W, Chabielska E. Angiotensin II via AT1 receptor accelerates arterial thrombosis in renovascular hypertensive rats. J Physiol Pharmacol 2005; 56: 571-585.
5. Dubinion JH, Mi Z, Jackson EK. Role of renal sympathetic nerves in regulating renovascular responses to angiotensin II in spontaneously hypertensive rats. J Pharmacol Exp Ther 2006; 317: 1330-1336.
6. Hilgers KF, Hartner A, Porst M, Veelken R, Mann JF. Angiotensin II type 1 receptor blockade prevents lethal malignant hypertension: relation to kidney inflammation. Circulation 2001; 104: 1436-1440.
7. Bidani AK, Griffin KA. Pathophysiology of hypertensive renal damage: implications for therapy. Hypertension 2004; 44: 595-601.
8. Zhu HB, Geng MY, Guan HS, Zhang JT. Antihypertensive effects of D-polymannuronic sulfate and its related mechanisms in renovascular hypertensive rats. Acta Pharmacol Sin 2000; 21: 727-732.
9. Goldblatt H. Hypertension of renal origin. Historical and experimental background. Am J Surg 1964; 107: 21-25.
10. Barger AC. The Goldblatt memorial lecture. Part I: experimental renovascular hypter-tension. Hypertension 1979; 1: 447-455.
11. Laragh JH. On the mechanisms and clinical relevance of one-kidney, one-clip hypertension. Am J Hypertens 1991; 4(10 Pt 2): 541S-545S.
12. Pinto YM, Paul M, Ganten D. Lessons from rat models of hypertension: from Goldblatt to genetic engineering. Cardiovasc Res 1998; 39: 77-88.
13. Goldblatt H. Experimental renal hypertension; mechanism of production and maintenance. Circulation 1958; 17(4, Part 2): 642-647.
14. Leenen FH, de Jong W. A solid silver clip for induction of predictable levels of renal hypertension in the rat. J Appl Physiol 1971; 31: 142-144.
15. Kirkby NS, Hadoke PW, Bagnall AJ, Webb DJ. The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house? Br J Pharmacol 2008; 153: 1105-1119.
16. Mulder P, Barbier S, Monteil C, Jeng AY, Henry JP, Renet S, Thuillez C. Sustained improvement of cardiac function and prevention of cardiac remodeling after long-term dual ECE-NEP inhibition in rats with congestive heart failure. J Cardiovasc Pharmacol 2004; 43: 489-494.
17. Emoto N, Raharjo SB, Isaka D, Masuda S, Adiarto S, Jeng AY, Yokoyama M. Dual ECE/NEP inhibition on cardiac and neurohumoral function during the transition from hypertrophy to heart failure in rats. Hypertension 2005; 45: 1145-1152.
18. Jagroop IA, Daskalopoulou SS, Mikhailidis DP. Endothelin-1 and human platelets. Curr Vasc Pharmacol 2005; 3: 393-399.