Clinical and immunological analysis of 23 adult patients with common variable immunodeficiency

Journal of Investigational Allergology and Clinical Immunology

Volumn 20, Issue 3, 2010, Pages 222-236

  Ardeniz, Ömür ^a   Basoglu O K ^a   Gunsar F ^a   Unsel M ^a   Bayraktaroglu S ^a   Mete, N ^a   Gulbahar O ^a   Sin, A ^a  

^a EGE UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Adults; Antibiotic prophylaxis; Cvid; Gastrointestinal manifestations; Granulomatous disease; IVIG therapy; Respiratory manifestations

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLARITHROMYCIN; COTRIMOXAZOLE; CYANOCOBALAMIN; ERYTHROMYCIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IRON COMPLEX; METRONIDAZOLE; MOXIFLOXACIN; NORFLOXACIN; ORNIDAZOLE; RETINOL; RIBAVIRIN; SALAZOSULFAPYRIDINE; TETRACYCLINE; THEOPHYLLINE; TIOTROPIUM BROMIDE; URSODEOXYCHOLIC ACID; VITAMIN D;

ADOLESCENT; ADULT; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; BONE DENSITY; BRONCHIECTASIS; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; COMMON VARIABLE IMMUNODEFICIENCY; COMORBIDITY; COMPUTER ASSISTED TOMOGRAPHY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GASTRITIS; GASTROINTESTINAL DISEASE; GIARDIASIS; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HEPATITIS C; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN DEFICIENCY; IRON DEFICIENCY ANEMIA; LIVER BIOPSY; LIVER GRANULOMA; LOWER RESPIRATORY TRACT INFECTION; LUNG FIBROSIS; LUNG FUNCTION TEST; LUNG LAVAGE; LYMPHADENOPATHY; LYMPHOID HYPERPLASIA; ONSET AGE; OSTEOMALACIA; OSTEOPOROSIS; RESPIRATORY TRACT INFECTION; SCLEROSING CHOLANGITIS; SPUTUM ANALYSIS; UPPER RESPIRATORY TRACT INFECTION; VITAMIN BLOOD LEVEL;

ADULT; AGED; BLOOD CHEMICAL ANALYSIS; COMMON VARIABLE IMMUNODEFICIENCY; FEMALE; GASTROINTESTINAL DISEASES; HUMANS; IMMUNOGLOBULINS; MALE; MIDDLE AGED; RESPIRATORY FUNCTION TESTS; RESPIRATORY TRACT DISEASES; RETROSPECTIVE STUDIES; TOMOGRAPHY, X-RAY COMPUTED; YOUNG ADULT;

EID: 77954378722     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol. 1999;92:34-48.
2. Park MA, Li JT, Hagan JB, Maddox DE, Abraham RS. Common variable immunodeficiency: a new look at an old disease. Lancet. 2008;372:489-502.
3. Cunningham-Rundles C, Radigan L. Deficient IL-12 and dendritic cell function in common variable immune deficiency. Clin Immunol. 2005;115:147-153.
4. Scott-Taylor TH, Green MR, Eren E, Webster AD. Monocyte derived dendritic cell responses in common variable immunodeficiency. Clin Exp Immunol. 2004;138:484-490.
5. Giovannetti A, Pierdominici M, Mazzetta F, Marziali M, Renzi C, Mileo AM, De Felice M, Mora B, Esposito A, Carello R, Pizzuti A, Paggi MG, Paganelli R, Malorni W, Aiuti F. Unravelling the complexity of T cell abnormalities in common variable immunodeficiency. J Immunol. 2007;178:3932-3943.
6. Cunningham-Rundles C, Radigan L, Knight AK, Zhang L, Bauer L, Nakazawa A. TLR9 activation is defective in common variable immune deficiency. J Immunol. 2006;176:1978-1987.
7. Fasano MB, Sullivan KE, Sarpong SB, Wood RA, Jones SM, Johns CJ, Lederman HM, Bykowsky MJ, Greene JM, Winkelstein JA. Sarcoidosis and common variable immunodeficiency. Report of 8 cases and review of the literature. Medicine (Baltimore). 1996;5:251-261.
8. Mechanic LJ, Dikman S, Cunningham-Rundles C. Granulomatous disease in common variable immunodeficiency. Ann Intern Med. 1997;127:613-617.
9. Spickett GP. Current perspectives on common variable immunodeficiency (CVID). Clin Exp Allergy. 2001;31:536-542.
10. Busse PJ, Farzan S, Cunningham-Rundles C. Pulmonary complications of common variable immunodeficiency. Ann Allergy Asthma Immunol. 2007;98:1-8.
11. Thickett KM, Kumararatne DS, Banerjee AK, Dudley R, Stableforth DE. Common variable immune deficiency: respiratory manifestations, pulmonary function and high-resolution CT scan findings. QJM. 2002;95:655-662.
12. Davies CW, Juniper MC, Gray W, Gleeson FV, Chapel HM, Davies RJ. Lymphoid interstitial pneumonitis associated with common variable hypogammaglobulinaemia treated with cyclosporin A. Thorax. 2000;55:88-90.
13. Tanaka N, Kim JS, Bates CA, Brown KK, Cool CD, Newell JD, Lynch DA. Lung diseases in patients with common variable immunodeficiency: chest radiographic, and computed tomographic findings. J Comput Assist Tomogr. 2006;30:828-838.
14. Seiler P, Aichele P, Bandermann S, Hauser AE, Lu B, Gerard NP, Gerard C, Ehlers S, Mollenkoph HJ, Kaufmann SH. Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3-signalling chemokines. Eur J Immunol. 2003;33:2676-2686.
15. Nembrini C, Marsland BJ, Kopf M. IL-17-producing T cells in lung immunity and inflammation. J Allergy Clin Immunol. 2009;123:986-994.
16. Ardeniz O, Cunningham-Rundles C. Granulomatous disease in common variable immunodeficiency. Clin Immunol. 2009;133:198-207;
17. Bates CA, Ellison MC, Lynch DA, Cool CD, Brown KK, Routes JM. Granulomatous-lymphocytic lung disease shortens survival in common variable immunodeficiency. J Allergy Clin Immunol. 2004;114:415-421.
18. Yu GP, Chiang D, Song SJ, Hoyte EG, Huang J, Vanishsarn C, Nadeau KC. Regulatory T cell dysfunction in subjects with common variable immunodeficiency complicated by autoimmune disease. Clin Immunol. 2009;131:240-253.
19. Fevang B, Yndestad A, Sandberg WJ, Holm AM, Müller F, Aukrust P, Froland SS. Low numbers of regulatory T cells in common variable immunodeficiency: association with chronic inflammation in vivo. Clin Exp Immunol. 2007;147:521-525.
20. Brandt D, Gershwin ME. Common variable immune deficiency and autoimmunity. Autoimmune Rev. 2006;5:465-470.
21. Mullighan CG, Marshall SE, Welsh KI. Mannose binding lectin polymorphisms are associated with early age of disease onset and autoimmunity in common variable immunodeficiency. Scand J Immunol. 2000;51:111-122.
22. Warnatz K, Denz A, Drager R, Braun M, Groth C, Wolff-Vorbeck G, Eibel H, Schlesier M, Peter HH. Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood. 2002;99:1544-1551.
23. Wehr C, Kivioja T, Schmitt C, Ferry B, Witte T, Eren E, Vlkova M, Hernandez M, Detkova D, Bos PR, Poerksen G, von Bernuth H, Baumann U, Goldacker S, Gutenberger S, Schlesier M, Bergeron-van der Cruyssen F, Le Garff M, Debre P, Jacobs R, Jones J, Bateman E, Litzman J, van Hagen PM, Plebani A, Schmidt RE, Thon V, Quinti I, Espanol T, Webster AD, Chapel H, Vihinen M, Oksenhendler E, Peter HH, Warnatz K. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood. 2008;111:77-85.
24. Kinlen LJ, Webster AD, Bird AG, Haile R, Peto J, Soothil JF, Thompson RA. Prospective study of cancer in patients with hypogammaglobulinemia. Lancet. 1985;1:263-266.
25. Cunningham-Rundles C, Siegal FP, Cunningham-Rundles S, Lieberman P. Incidence of cancer in 98 patients with common variable immunodeficiency. J Clin Immunol. 1987;7:294-299.
26. Desar IM, Keuter M, Raemaekers JM, Jansen JB, van Krieken JH, van der Meer JW. Extranodal marginal zone (MALT) lymphoma in common variable immunodeficiency. Neth J Med. 2006;64:136-140.
27. Kohler PF, Cook RD, Brown WR, Manguso RL. Common variable hypogammaglobulinemia with T-cell nodular lymphoid interstitial pneumonitis and B cell nodular lymphoid hyperplasia: different lymphocyte populations with a similar response to prednisone therapy. J Allergy Clin Immunol. 1982;70:299-305.
28. Daniels JA, Lederman HM, Maitra A, Montgomery EA. Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): A clinicopathologic study and review. Am J Surg Pathol. 2007;31:1800-1812.
29. Onbasi K, Günşar F, Sin A, Ardeniz 0, Kokuludag A, Sebik F. Common variable immunodeficiency (CVID) presenting with malabsorption due to giardiasis. Turk J Gastroenterol. 2005;16:111-113.
30. Khodadad A, Aghamohammadi A, Parvaneh N, Rezaei N, Mahjoob F, Bashashati M, Movahedi M, Fazlollahi MR, Zandieh F, Roohi Z, Abdollahzade S, Salavati A, Kouhi A, Talebpour B, Daryani NE. Gastrointestinal manifestations in patients with common variable immunodeficiency. Dig Dis Sci. 2007;52:2977-2983.
31. Zullo A, Romiti A, Rinaldi V, Vecchione A, Tomao S, Aiuti F, Frati L, Luzi G. Gastric pathology in patients with common variable immunodeficiency. Gut. 1999;45:77-81.
32. Luzi G, Zullo A, Iebba F, Rinaldi V, Sanchez Mete L, Muscaritoli M, Aiuti F. Duodenal pathology and clinical-immunological implications in common variable immunodeficiency patients. Am J Gastroenterol. 2003;98:118-121.
33. Mannon PJ, Fuss IJ, Dill S, Friend J, Groden C, Hornung R, Yang Z, Yi C, Quezado M, Brown M, Strober W. Excess IL-12 but not IL-23 accompanies the inflammatory bowel disease associated with common variable immunodeficiency. Gastroenterology. 2006;131:748-756.
34. Eijkhout HW, van Der Meer JW, Kallenberg CG, Weening RS, van Dissel JT, Sanders LA, Strengers PF, Nienhuis H, Schellekens PT, Inter-University Working Party for the Study of Immune Deficiencies. The effect of two different dosages of intravenous immunoglobulin on the incidence of recurrent infections in patients with primary hypogammaglobulinemia: a randomized, double-blind, multicenter crossover trial. Ann Intern Med. 2001;135:165-174.