Transdifferentiation of adipose-derived stem cells into hepatocytes: a new approach

Liver International

Volumn 30, Issue 6, 2010, Pages 913-922

  Lue, James ^a   Lin, Guiting ^b   Ning, Hongxiu ^b   Xiong, Anming ^c   Lin, Ching Shwun ^b   Glenn, Jeffrey S ^c  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adipose; Hepatic differentiation; Hepatocyte; Liver; Mesenchymal stem cell

Indexed keywords

ALBUMIN; GROWTH FACTOR; LIVER PROTEIN; LOW DENSITY LIPOPROTEIN; TRANSCRIPTION FACTOR; ALBUMINOID;

ADIPOSE TISSUE CELL; ARTICLE; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; CULTURE MEDIUM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LIVER CELL; MESENCHYMAL STEM CELL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ADIPOSE TISSUE; ADULT; ADULT STEM CELL; AGED; CELL CULTURE; CELL LINEAGE; CELL SHAPE; CYTOLOGY; FEMALE; GENE VECTOR; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; GENETICS; IMMUNOHISTOCHEMISTRY; LENTIVIRINAE; MALE; MESENCHYMAL STROMA CELL; METABOLISM; MIDDLE AGED; PHYSIOLOGY; TIME; WESTERN BLOTTING;

ADIPOSE TISSUE; ADULT; ADULT STEM CELLS; AGED; ALBUMINS; BLOTTING, WESTERN; CELL LINEAGE; CELL SHAPE; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; FEMALE; GENETIC VECTORS; HEPATOCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; LENTIVIRUS; LIPOPROTEINS, LDL; MALE; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSDUCTION, GENETIC;

EID: 77954377318     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2010.02231.x     Document Type: Article

References (27)

1. Rubio D, Garcia-Castro J, Martin MC. Spontaneous human adult stem cell transformation. Cancer Res 2005, 65:3035-9.
2. Fraser JK, Schreiber R, Strem B. Plasticity of human adipose stem cells toward endothelial cells and cardiomyocytes. Nat Clin Pract Cardiovasc Med 2006, 3((Suppl. 1)):S33-7.
3. Seo MJ, Suh SY, Bae YC, Jung JS. Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem Biophys Res Commun 2005, 328:258-64.
4. Talens-Visconti R, Bonora A, Jover R. Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells. World J Gastroenterol 2006, 12:5834-45.
5. Banas A, Teratani T, Yamamoto Y. Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure. J Gastroenterol Hepatol 2009, 24:70-7.
6. Banas A, Teratani T, Yamamoto Y. Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatology 2007, 46:219-28.
7. Aurich I, Mueller LP, Aurich H. Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers. Gut 2007, 56:405-15.
8. Aurich H, Sgodda M, Kaltwasser P. Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo. Gut 2009, 58:570-81.
9. Sgodda M, Aurich H, Kleist S. Hepatocyte differentiation of mesenchymal stem cells from rat peritoneal adipose tissue in vitro and in vivo. Exp Cell Res 2007, 313:2875-86.
10. Zemel R, Bachmetov L, Ad-El D, Abraham A, Tur-Kaspa R. Expression of liver-specific markers in naive adipose-derived mesenchymal stem cells. Liver Int 2009, 29:1326-37.
11. Ishii K, Yoshida Y, Akechi Y. Hepatic differentiation of human bone marrow-derived mesenchymal stem cells by tetracycline-regulated hepatocyte nuclear factor 3beta. Hepatology 2008, 48:597-606.
12. Lee CS, Friedman JR, Fulmer JT, Kaestner KH. The initiation of liver development is dependent on Foxa transcription factors. Nature 2005, 435:944-7.
13. Friedman JR, Kaestner KH. The Foxa family of transcription factors in development and metabolism. Cell Mol Life Sci 2006, 63:2317-28.
14. Seguin CA, Draper JS, Nagy A, Rossant J. Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells. Cell Stem Cell 2008, 3:182-95.
15. Li J, Ning G, Duncan SA. Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha. Genes Dev 2000, 14:464-74.
16. Ning H, Lin G, Lue TF, Lin CS. Neuron-like differentiation of adipose tissue-derived stromal cells and vascular smooth muscle cells. Differentiation 2006, 74:510-8.
17. Lin G, Garcia M, Ning H. Defining stem and progenitor cells within adipose tissue. Stem Cells Dev 2008, 17:1053-63.
18. Suchy FJ, Sokol RJ, Balistreri WF. Liver disease in children 2007, 3rd edn, New York, NY, Cambridge University Press
19. McLin VA, Zorn AM. Molecular control of liver development. Clin Liver Dis 2006, 10:1-25. v
20. Spear BT, Jin L, Ramasamy S, Dobierzewska A. Transcriptional control in the mammalian liver: liver development, perinatal repression, and zonal gene regulation. Cell Mol Life Sci 2006, 63:2922-38.
21. Tanimizu N, Miyajima A. Molecular mechanism of liver development and regeneration. Int Rev Cytol 2007, 259:1-48.
22. Zorn AM, Wells JM. Molecular basis of vertebrate endoderm development. Int Rev Cytol 2007, 259:49-111.
23. Banas A, Teratani T, Yamamoto Y. IFATS collection: in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury. Stem Cells 2008, 26:2705-12.
24. Puissant B, Barreau C, Bourin P. Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells. Br J Haematol 2005, 129:118-29.
25. Zaret KS. Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation. Nat Rev Genet 2008, 9:329-40.
26. Takahashi K, Tanabe K, Ohnuki M. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-72.
27. Fink DW. FDA regulation of stem cell-based products. Science 2009, 324:1662-3.