Sodium L-ascorbyl-2-phosphate 5% lotion for the treatment of acne vulgaris: A randomized, double-blind, controlled trial

Journal of Cosmetic Dermatology

Volumn 9, Issue 1, 2010, Pages 22-27

  Woolery Lloyd, Heather ^a   Baumann, Leslie ^b   Ikeno, Hiroshi ^c  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b Baumann Cosmetic and Research Institute   (United States)

^c Ikeno Clinic of Dermatology and Dermatologic Surgery   (Japan)

Author keywords

Acne; Acne vulgaris; Antioxidant; Ascorbic acid; Sodium L ascorbyl 2 phosphate; Vitamin C

Indexed keywords

ASCORBIC ACID DERIVATIVE; DERMATOLOGICAL AGENT; SODIUM LEVO ASCORBYL 2 PHOSPHATE; UNCLASSIFIED DRUG;

ACNE VULGARIS; ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG TOLERABILITY; DRY SKIN; ERYTHEMA; GLOBAL ASSESSMENT SCORE; HUMAN; LOTION; MONOTHERAPY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SKIN MANIFESTATION; SKIN SCALING;

ACNE VULGARIS; ADMINISTRATION, CUTANEOUS; ADOLESCENT; ADULT; ANTIOXIDANTS; ASCORBIC ACID; DERMATOLOGIC AGENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; OINTMENTS; PHOSPHATES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 77954372611     PISSN: 14732130     EISSN: 14732165     Source Type: Journal    
DOI: 10.1111/j.1473-2165.2010.00480.x     Document Type: Article

References (20)

1. Saint-Leger D, Bague A, Cohen E, Chivot M. A possible role for squalene in the pathogenesis of acne. I. In vitro study of squalene oxidation. Br J Dermatol 1986, 114:535-42.
2. Saint-Leger D, Bague A, Lefebvre E, Cohen E, Chivot M. A possible role for squalene in the pathogenesis of acne. II. In vivo study of squalene oxides in skin surface and intra-comedonal lipids of acne patients. Br J Dermatol 1986, 114:543-52.
3. Miyachi Y, Yoshioka A, Imamura S, Niwa Y. Effect of antibiotics on the generation of reactive oxygen species. J Invest Dermatol 1986, 86:449-53.
4. Akamatsu H, Asada M, Komura J, Asada Y, Niwa Y. Effect of doxycycline on the generation of reactive oxygen species: a possible mechanism of action of acne therapy with doxycycline. Acta Derm Venereol 1992, 72:178-9.
5. Spiclin P, Homar M, Zupancic-Valant A, Gasperlin M. Sodium ascorbyl phosphate in topical microemulsions. Int J Pharm 2003, 256:65-73.
6. Nayama S, Takehana M, Kanke M, Itoh S, Ogata E, Kobayashi S. Protective effects of sodium-L-ascorbyl-2 phosphate on the development of UVB-induced damage in cultured mouse skin. Biol Pharm Bull 1999, 22:1301-5.
7. Ikeno H, Nishikawa T, Ohmori K. An Open Study Comparing Efficacy of 5% Sodium L-Ascorbyl-2-Phosphate Lotion Versus 1% Clindamycin Phosphate Lotion and Vehicle Lotion in the Treatment of Acne Vulgaris 2003, Miami Beach, Fla, Poster presented at: International Investigative Dermatology Meeting, May 4
8. Klock J, Ikeno H, Ohmori K, Nishikawa T, Volhardt J, Schehlmann V. Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the prevention and treatment of acne vulgaris. Int J Cosmet Sci 2005, 27:171-6.
9. Ikeno H, Ohmori K, Yunoki S, Nishikawa T. Open study comparing 5% sodium L-ascorbyl-2-phosphate lotion versus 1% clindamycin phosphate lotion for acne vulgaris. J Cosmet Dermatol 2006, 19:43-8.
10. Ikeno H, Ohmori K. Open study comparing 5% sodium L-ascorbyl-2-phosphate lotion versus Adapalene 0.1% gel for acne vulgaris. J Cosmet Dermatol 2007, 20:368-72.
11. Ikeno H. Evaluation of clinical efficacy of combination treatment with clindamycin lotion plus vitamin C derivative lotion. Aesthet Dermatol Japan 1998, 8:83-8.
12. Morris GE. Use of vitamin C in acne vulgaris. A. M. A. Arch Derm Syphilol 1954, 70:363-4.
13. Rose RC. Transport of ascorbic acid and other water soluble vitamins. Biochim Biophys Acta 1988, 947:335-66.
14. Shindo Y, Witt E, Hans D, Epstein W, Packer L. Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol 1994, 102:122-4.
15. Austria R, Semenzato A, Bettero A. Stability of vitamin C derivatives in solution and topical formulations. J Pharm Biomed Anal 1997, 15:795-801.
16. Elmore AR. Final report of the safety assessment of l-ascorbic acid, calcium ascorbate, magnesium ascorbate, magnesium ascorbyl phosphate, sodium ascorbate, and sodium ascorbyl phosphate as used in cosmetics. Int J Toxicol 2005, 24(Suppl. 2):51-111.
17. Farris PK. Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg 2005, 31:814-7. discussion 818
18. Basak PY, Gultekin F, Kilinc I. The role of the antioxidative defense system in papulopustular acne. J Dermatol 2001, 28:123-7.
19. Bowles WH. Protection against minocycline pigment formation by ascorbic acid. J Esthet Dent 1998, 10:182-6.
20. Kameyama K, Saka C, Kondoh S, Yonemoto K, Nishiyama S, Tagawa M, Murata T, Ohnuma T, Quigley J, Dorsky A, Bucks D, Blanock K. Inhibitory effect of magnesium l-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo. J Am Acad Dermatol 1996, 34:29-33.