Exposure of IgG to an acidic environment results in molecular modifications and in enhanced protective activity in sepsis

FEBS Journal

Volumn 277, Issue 14, 2010, Pages 3039-3050

  Djoumerska Alexieva, Iglika K ^a   Dimitrov, Jordan D ^a,b,c   Voynova, Elisaveta N ^a   Lacroix Desmazes, Sebastien ^b,c   Kaveri, Srinivas V ^b,c   Vassilev, Tchavdar L ^a  

^a BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

antibodies; antibody polyreactivity; antigen antibody interaction; IgG; immunoglobulins

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; PROTEIN A; PROTEIN G;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; EXPOSURE; HYDROPHOBICITY; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK;

ANILINO NAPHTHALENESULFONATES; ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS, BACTERIAL; AUTOANTIGENS; BLOTTING, WESTERN; BUFFERS; C-REACTIVE PROTEIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FLUORESCENT DYES; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; IMMUNOGLOBULINS, INTRAVENOUS; INTERFERON-GAMMA, RECOMBINANT; KINETICS; MICE; MICE, INBRED ICR; MICROSCOPY, FLUORESCENCE; PROTEIN CONFORMATION; SEPSIS; SURVIVAL ANALYSIS;

BACTERIA (MICROORGANISMS); MUS;

EID: 77954369901     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07714.x     Document Type: Article

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