Effects of testosterone in older men with mild-to-moderate cognitive impairment

Journal of the American Geriatrics Society

Volumn 58, Issue 7, 2010, Pages 1419-1421

  Fukai, Shiho ^a   Akishita, Masahiro ^a   Yamada, Shizuru ^b   Toba, Kenji ^b   Ouchi, Yasuyoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYORIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TESTOSTERONE UNDECANOATE;

AGED; CASE REPORT; COGNITION; COGNITIVE DEFECT; DISEASE CLASSIFICATION; GERIATRICS; HASEGAWA DEMENTIA SCALE REVISED; HUMAN; LETTER; LIVER FUNCTION TEST; LONG TERM CARE; MALE; MINI MENTAL STATE EXAMINATION; PILOT STUDY; SCORING SYSTEM; SIDE EFFECT; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION;

AGED; AGED, 80 AND OVER; ANDROGENS; COGNITION DISORDERS; COHORT STUDIES; DRUG ADMINISTRATION SCHEDULE; HUMANS; MALE; PILOT PROJECTS; TESTOSTERONE;

EID: 77954346979     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2010.02946.x     Document Type: Letter

References (10)

1. Yaffe K, Lui LY, Zmuda J et al. Sex hormones and cognitive function in older men. J Am Geriatr Soc 2002 50 : 707 712.
2. Moffat SD, Zonderman AB, Metter EJ et al. Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. J Clin Endocrinol Metab 2002 87 : 5001 5007.
3. Fukai S, Akishita M, Yamada S et al. Association of plasma sex hormone levels with functional decline in elderly men and women. Geriatr Gerontol Int 2009 9 : 282 289.
4. Cherrier MM, Matsumoto AM, Amory JK et al. Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment. Neurology 2005 64 : 2063 2068.
5. Tan RS, Pu SJ. A pilot study on the effects of testosterone in hypogonadal aging male patients with Alzheimer's disease. Aging Male 2003 6 : 13 17.
6. Kenny AM, Fabregas G, Song C et al. Effects of testosterone on behavior, depression, and cognitive function in older men with mild cognitive loss. J Gerontol A Biol Sci Med Sci 2004 59A : 75 78.
7. Lu PH, Masterman DA, Mulnard R et al. Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men. Arch Neurol 2006 63 : 177 185.
8. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999 84 : 3666 3672.
9. Houwing NS, Maris F, Schnabel PG et al. Pharmacokinetic study in women of three different doses of a new formulation of oral testosterone undecanoate, Andriol Testocaps. Pharmacotherapy 2003 23 : 1257 1265.
10. Toba K, Nakai R, Akishita M et al. Vitality Index as a useful tool to assess elderly with dementia. Geriatr Gerontol Int 2002 2 : 23 29.