Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 13, 2010, Pages 3848-3850

  Bokesch, Heidi R ^a,b   Cartner, Laura K ^a,b   Fuller, Richard W ^a   Wilson, Jennifer A ^a   Henrich, Curtis J ^a,b   Kelley, James A ^a   Gustafson, Kirk R ^a   McMahon, James B ^a   McKee, Tawnya C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

ABCG2; Crinoids; Marine natural products; Napthopyrones

Indexed keywords

5,8 DIHYDROXY 6 METHOXY 2 PROPYL 4H NAPHTHO[2,3 B]PYRAN 4 ONE; 6 METHOXYCOMAPARVIN; 6 METHOXYCOMAPARVIN 5 METHYL ETHER; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; COMAPARVIN; FUMITREMORGIN C; NAPHTHOPYRONE DERIVATIVE; PYRONE DERIVATIVE; TMC 256A1; TMC 256C1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RESISTANCE; COMASTERIDAE; CONTROLLED STUDY; DRUG ISOLATION; DRUG SCREENING; ECHINODERM; HUMAN; HUMAN CELL;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ECHINODERMATA; HUMANS; MOLECULAR CONFORMATION; NAPHTHALENES; NEOPLASM PROTEINS; PYRONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

COMASTERIDAE; PELMATOZOA;

EID: 77954316198     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.05.057     Document Type: Article

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