Fixed artesunate-amodiaquine combined pre-formulation study for the treatment of malaria

International Journal of Pharmaceutics

Volumn 395, Issue 1-2, 2010, Pages 198-204

  Kauss, Tina ^a   Fawaz, Fawaz ^a   Guyot, Michel ^a   Lagueny, Anne Marie ^a   Dos Santos, Isabelle ^a   Bonini, François ^a   Olliaro, Piero ^b,c   Caminiti, Antonella ^d   Millet, Pascal ^d  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b WORLD HEALTH ORGANIZATION   (Switzerland)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Centre René Labusquière   (France)

Author keywords

Amodiaquine; Artesunate; Malaria; Pre formulation

Indexed keywords

4 AMINOQUINOLINE; AEROSIL; AMODIAQUINE; ARTESUNATE; ASAQ; COARSUCAM; CROSCARMELLOSE SODIUM; MAGNESIUM STEARATE; POVIDONE; POVIDONE K30; SILICON DIOXIDE; UNCLASSIFIED DRUG; WINTHROP; ALCOHOL; AMODIAQUINE, ARTESUNATE DRUG COMBINATION; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; DRUG COMBINATION; POWDER; SOLVENT; TABLET; WATER;

ARTICLE; DRUG FORMULATION; MALARIA; PREFORMULATION; PRIORITY JOURNAL; TABLET; TEMPERATURE; WATER CONTENT; CHEMISTRY; DRUG COMBINATION; DRUG STABILITY; FEASIBILITY STUDY; HEAT; HUMIDITY; KINETICS; MALARIA, FALCIPARUM; MEDICINAL CHEMISTRY; PH; POWDER; SOLUBILITY;

AMODIAQUINE; ANTIMALARIALS; ARTEMISININS; CHEMISTRY, PHARMACEUTICAL; DRUG COMBINATIONS; DRUG COMPOUNDING; DRUG STABILITY; ETHANOL; FEASIBILITY STUDIES; HOT TEMPERATURE; HUMIDITY; HYDROGEN-ION CONCENTRATION; KINETICS; MALARIA, FALCIPARUM; POWDERS; SOLUBILITY; SOLVENTS; TABLETS; WATER;

EID: 77954314059     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.05.038     Document Type: Article

References (15)

1. Adjuik M., Babiker A., Garner P., Olliaro P., Taylor W., et al. Artesunate combinations for treatment of malaria: meta-analysis. Lancet 2004, 363:9-17.
2. Batty K.T., Thu L.T., Davis T.M., Ilett K.F., Mai T.X., et al. A pharmacokinetic and pharmacodynamic study of intravenous vs. oral artesunate in uncomplicated falciparum malaria. Br. J. Clin. Pharmacol. 1998, 45:123-129.
3. Beer, N., Ali, A.S., Rotllant, G., Abass, A.K,, Omari, R.S., et al., 2009. Adherence to artesunate-amodiaquine combination therapy for uncomplicated malaria in children in Zanzibar, Tanzania.
4. Brasseur P., Agnamey P., Gaye O., Cisse M., Badiane M., et al. Dosing accuracy of artesunate and amodiaquine as treatment for falciparum malaria in Casamance, Senegal. Trop. Med. Int. Health 2009, 14:79-87. (Epub 2008 Nov 2014).
5. Croft S.L. Public-private partnership: from there to here. Trans. R. Soc. Trop. Med. Hyg. 2005, 99(Suppl. 1):S9-S14.
6. Gaudin K., Langlois M.-H., Barbaud A., Boyer C., Millet P., et al. Stability of artesunate in pharmaceutical solvents. J. Pharm. Biomed. Anal. 2007, 43:1019-1024.
7. Haynes R.K. From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements. Curr. Top. Med. Chem. 2006, 6:509-537.
8. Haynes R.K., Chan H.W., Lung C.M., Ng N.C., Wong H.N., et al. Artesunate and dihydroartemisinin (DHA): unusual decomposition products formed under mild conditions and comments on the fitness of DHA as an antimalarial drug. ChemMedChem 2007, 2:1448-1463.
9. Navaratnam V., Ramanathan S., Wahab M.S., Siew Hua G., Mansor S.M., et al. Tolerability and pharmacokinetics of non-fixed and fixed combinations of artesunate and amodiaquine in Malaysian healthy normal volunteers. Eur. J. Clin. Pharmacol. 2009, 30:30.
10. Ndiaye J.L., Randrianarivelojosia M., Sagara I., Brasseur P., Ndiaye I., et al. Randomized, multicentre assessment of the efficacy and safety of ASAQ-a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria. Malar. J. 2009, 8:125.
11. Ruttimann J. Halt called on single-drug antimalarial prescriptions 2006, Nature News.
12. Sirima S.B., Tiono A.B., Gansane A., Diarra A., Ouedraogo A., et al. The efficacy and safety of a new fixed-dose combination of amodiaquine and artesunate in young African children with acute uncomplicated Plasmodium falciparum. Malar. J. 2009, 8:48.
13. Taylor W.R., Terlouw D.J., Olliaro P.L., White N.J., Brasseur P., et al. Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria. Bull. World Health Organ. 2006, 84:956-964.
14. WHO Guidelines for the Treatment of Malaria/World Health Organization 2006, World Health Organisation, Geneva, Switzerland.
15. Zwang J., Olliaro P., Barennes H., Bonnet M., Brasseur P., et al. Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis. Malar. J. 2009, 8:203.