Paracrine factors secreted by endothelial progenitor cells prevent oxidative stress-induced apoptosis of mature endothelial cells

Atherosclerosis

Volumn 211, Issue 1, 2010, Pages 103-109

  Yang, Zijiang ^a   von Ballmoos, Moritz Wyler ^b   Faessler, Daniel ^a   Voelzmann, Jan ^a   Ortmann, Jana ^a   Diehm, Nicolas ^a   Kalka Moll, Wiltrud ^c   Baumgartner, Iris ^a   Di Santo, Stefano ^a   Kalka, Christoph ^a  

^a BERN UNIVERSITY HOSPITAL   (Switzerland)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

Apoptosis; Endothelial cells; Endothelial progenitor cells; Oxidative stress; Paracrine factors

Indexed keywords

ANTIOXIDANT; CATALASE; GELATINASE B; HYDROGEN PEROXIDE; INTERLEUKIN 8; MANGANESE SUPEROXIDE DISMUTASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; VASCULOTROPIN; CULTURE MEDIUM;

APOPTOSIS; ARTICLE; CELL PROTECTION; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; ENZYME ACTIVITY; IMMUNOBLOTTING; OXIDATIVE STRESS; PARACRINE SIGNALING; PRIORITY JOURNAL; STEM CELL; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; HUMAN; METABOLISM; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

APOPTOSIS; CULTURE MEDIA, CONDITIONED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; OXIDATIVE STRESS; PARACRINE COMMUNICATION; STEM CELLS;

EID: 77954313786     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.02.022     Document Type: Article

References (30)

1. Zhang C. The role of inflammatory cytokines in endothelial dysfunction. Basic Res Cardiol 2008, 103:398-406.
2. Dernbach E., Urbich C., Brandes R.P., et al. Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress. Blood 2004, 104:3591-3597.
3. Heistad D.D. Oxidative stress and vascular disease: 2005 Duff lecture. Arterioscler Thromb Vasc Biol 2006, 26:689-695.
4. Asahara T., Krasinski K.L., Chen D., et al. Circulating endothelial progenitor cells in peripheral blood incorporate into re-endothelialization after vascular injury. Circulation 1997, 96:I-725.
5. Di Santo S., Yang Z., von Ballmoos M.W., et al. Novel cell-free strategy for therapeutic angiogenesis: in vitro generated conditioned medium can replace progenitor cell transplantation. PLoS ONE 2009, 4:e5643.
6. Jaffe E.A., Nachman R.L., Becker C.G., Minick C.R. Culture of human endothelial cells derived from umbilical veins. J Clin Invest 1973, 52:2745-2756.
7. Kalka C., Masuda H., Takahashi T., et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci USA 2000, 97:3422-3427.
8. Di Santo S., Diehm N., Ortmann J., et al. Oxidized low density lipoprotein impairs endothelial progenitor cell function by downregulation of E-selectin and integrin alpha(v)beta5. Biochem Biophys Res Commun 2008, 373:528-532.
9. Rehman J., Li J., Orschell C.M., March K.L. Peripheral blood " endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 2003, 107:1164-1169.
10. Diehm N., Di Santo S., Schaffner T., et al. Severe structural damage of the seemingly non-diseased infrarenal aortic aneurysm neck. J Vasc Surg 2008, 48:425-434.
11. Yoon C.H., Hur J., Park K.W., et al. Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: the role of angiogenic cytokines and matrix metalloproteinases. Circulation 2005, 112:1618-1627.
12. Krenning G., van Luyn M.J., Harmsen M.C. Endothelial progenitor cell-based neovascularization: implications for therapy. Trends Mol Med 2009, 15:180-189.
13. Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002, 82:47-95.
14. Dimmeler S., Hermann C., Galle J., Zeiher A.M. Upregulation of superoxide dismutase and nitric oxide synthase mediates the apoptosis-suppressive effects of shear stress on endothelial cells. Arterioscler Thromb Vasc Biol 1999, 19:656-664.
15. Thomas S.R., Witting P.K., Drummond G.R. Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 2008, 10:1713-1765.
16. Kumar S., Sun X., Wedgwood S., Black S.M. Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of AP-1 activity. Am J Physiol Lung Cell Mol Physiol 2008, 295:L370-377.
17. Heitzer T., Schlinzig T., Krohn K., Meinertz T., Munzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001, 104:2673-2678.
18. Tousoulis D., Andreou I., Antoniades C., Tentolouris C., Stefanadis C. Role of inflammation and oxidative stress in endothelial progenitor cell function and mobilization: therapeutic implications for cardiovascular diseases. Atherosclerosis 2008, 201:236-247.
19. Urbich C., Aicher A., Heeschen C., et al. Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. J Mol Cell Cardiol 2005, 39:733-742.
20. Prater D.N., Case J., Ingram D.A., Yoder M.C. Working hypothesis to redefine endothelial progenitor cells. Leukemia 2007, 21:1141-1149.
21. Hur J., Yoon C.H., Kim H.S., et al. Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arterioscler Thromb Vasc Biol 2004, 24:288-293.
22. 2-induced cell death. Am J Respir Cell Mol Biol 2003, 29:513-522.
23. Zhang F., Tang Z., Hou X., et al. VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis. Proc Natl Acad Sci USA 2009, 106:6152-6157.
24. Fukuo K., Yang J., Suzuki T., et al. Nifedipine upregulates manganese superoxide dismutase expression in vascular smooth muscle cells via endothelial cell-dependent pathways. Hypertens Res 2003, 26:503-508.
25. Abid M.R., Schoots I.G., Spokes K.C., et al. Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB. J Biol Chem 2004, 279:44030-44038.
26. He T., Peterson T.E., Holmuhamedov E.L., et al. Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase. Arterioscler Thromb Vasc Biol 2004, 24:2021-2027.
27. Kondo S., Tang Y., Scheef E.A., Sheibani N., Sorenson C.M. Attenuation of retinal endothelial cell migration and capillary morphogenesis in the absence of bcl-2. Am J Physiol Cell Physiol 2008, 294:C1521-1530.
28. Singla D.K., Singla R.D., McDonald D.E. Factors released from embryonic stem cells inhibit apoptosis in H9c2 cells through PI3K/Akt but not ERK pathway. Am J Physiol Heart Circ Physiol 2008, 295:H907-913.
29. Kim W.S., Park B.S., Kim H.K., et al. Evidence supporting antioxidant action of adipose-derived stem cells: protection of human dermal fibroblasts from oxidative stress. J Dermatol Sci 2008, 49:133-142.
30. Zhang Y., Ingram D.A., Murphy M.P., et al. Release of pro-inflammatory mediators and expression of pro-inflammatory adhesion molecules by endothelial progenitor cells. Am J Physiol Heart Circ Physiol 2009.