Preventive effects of chinese Herb Chai-Hu-Gui-Zhi-Tang extract on water immersion restraint stress-induced acute gastric ulceration in rats

Journal of Veterinary Medical Science

Volumn 72, Issue 6, 2010, Pages 679-685

  Chen, Chi Yang ^a   Kuo, Tsung Li ^b   Sheu, Shi Yuan ^c,d   Kuo, Tzong Fu ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d E DA HOSPITAL   (Taiwan)

Author keywords

Antioxidant effect; Chai hu gui zhi tang (CHGZT); Gastric ulcer; Non protein sulfhydryls; Water immersion restraint stress

Indexed keywords

PLANT EXTRACT; THIOL DERIVATIVE;

ANIMAL; ARTICLE; CHINESE MEDICINE; EXERCISE; GINSENG; LIVER; MALE; MENTAL STRESS; METABOLISM; PATHOLOGY; PSYCHOLOGICAL ASPECT; RAT; STOMACH MUCOSA; STOMACH ULCER; WISTAR RAT;

ANIMALS; GASTRIC MUCOSA; LIVER; MALE; MEDICINE, CHINESE TRADITIONAL; PANAX; PLANT EXTRACTS; RATS; RATS, WISTAR; RESTRAINT, PHYSICAL; STOMACH ULCER; STRESS, PSYCHOLOGICAL; SULFHYDRYL COMPOUNDS;

RATTUS; RATTUS NORVEGICUS;

EID: 77954301118     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.09-0284     Document Type: Article

References (34)

1. Al-Yahya, M. A., Rafatullah, S., Mossa, J. S., Ageel, A. M., Parmar, N. S. and Tariq, M. 1989. Gastroprotective activity of ginger zingiber officinale rosc., in albino rats. Am. J. Chin. Med. 17: 51-56.
2. Bandyopadhyay, U., Biswas, K., Chatterjee, R., Bandyopadhyay, D., Chattopadhyay, I., Ganguly, C. K., Chakraborty, T., Bhattacharya, K. and Banerjee, R. K. 2002. Gastroprotective effect of Neem (Azadirachta indica) bark extract: possible involvement of H+-K+-ATPase inhibition and scavenging of hydroxyl radical. Life Sci. 71: 2845-2865.
3. Bochorakova, H., Paulova, H., Slanina, J., Musil, P. and Taborska, E. 2003. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Phytother. Res. 17: 640-644.
4. Body, S. C., Sasame, H. A. and Body, M. R. 1981. Gastric glutathione depletion and acute ulcerogensis by diehtylmaleate given subcutaneously to rats. Life Sci. 28: 2987-2992.
5. Brzozowski, T., Konturek, S. J., Sliwowski, Z., Pytko-Polonczyk, J., Szlachcic, A. and Drozdowicz, D. 1996. Role of capsaicin-sensitive sensory nerves in gastroprotection against acidindependent and acid-dependent ulcerogenesis. Digestion 57: 424-432.
6. Chi, Y. S., Lim, H., Park, H. and Kim, H. P. 2003. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem. Pharmacol. 66: 1271-1278.
7. Ding, J., Chen, J. Z. and Li, Z. Y. 2007. An experimental study on the structural and functional changes of gastric mucosa in rats with liver-qi stagnation syndrome. Liaoning J. Tradit. Chin. Med. 34: 229-232.
8. Ernst, H., Konturek, P. C., Brzozowski, T., Lochs, H., Hahn, E. G. and Konturek, S. J. 1998. Adaptation of gastric mucosa to stress. Effect of ranitidine. J. Physiol. Pharmacol. 49: 405-419.
9. Glavin, G. B., Murison, R., Overmier, J. B., Pare, W.P., Bakke, H. K., Henke, P.G. and Hernandez, D. E. 1991. The neurobiology of stress ulcers. Brain Res. Brain Res. Rev. 16: 301-343.
10. Hayase, M. and Takeuchi, K. 1986. Gastric acid secretion and lesion. Formation in rats under water-immersion stress. Dig. Dis. Sci. 31: 166-171.
11. Jeong, C. S., Hyun, J. E. and Kim, Y. S. 2003. Ginsenoside Rb1: the anti-ulcer constituent from the head of Panax ginseng. Arch. Pharm. Res. 26: 906-911.
12. Komatsu, M., Hiramatsu, M., Yokoyama, H. and Willmore, L. J. 1996. Effect of TJ-960 (a Japanese herbal medicine) on free radical changes within an iron-induced focal epileptogenic region in rat brain measured by in vivo L-band electron spin resonance. Neurosci. Lett. 205: 189-192.
13. Lee, S. C., Kwon, Y. S., Son, K. H., Kim, H. P. and Heo, M. Y. 2005. Antioxidative constituents from Paeonia lactiflora. Arch. Pharm. Res. 28: 775-783.
14. Nagy, L., Nagata, M. and Szabo, S. 2007. Protein and non-protein sulfhydryls and disulfides in gastric mucosa and liver after gastrotoxic chemicals and sucralfate: possible new targets of pharmacologic agents. World J. Gastroenterol. 13: 2053-2060.
15. Naito, Y., Yoshikawa, T., Iinuma, S., Yagi, N., Matsuyama, K., Boku, Y., Fujii, T., Yoshida, N., Kondo, M. and Sasaki, E. 1998. Rebamipide protects against indomethacin-induced gastric mucosal injury in healthy volunteers in a double-blind, placebo-controlled study. Dig. Dis. Sci. 43: 83S-89S.
16. Nishida, K., Ohta, Y., Kobayashi, T. and Ishiguro, I. 1997. Involvement of xanthine oxidase system and neutrophils in the development of acute gastric mucosal lesions in rats with water immersion restraint stress. Digestion 58: 340-351.
17. Ohta, Y., Kobayashi, T., Nishida, K., Nagata, M. and Ishiguro, I. 1999. Therapeutic effect of Oren-gedoku-to extract on stressinduced acute gastric mucosal lesions in rats. Phytother. Res. 13: 588-592.
18. Podoprigorova, V. G., Khibin, L. S., Kozlov, N. B. and Barsel, V. A. 1999. Effectiveness of synthetic antioxidants in treatment of patients with peptic ulcer an open randomized controlled trial. Klin. Med. 77: 32-35.
19. Sedlak, J. and Lindsay, R. H. 1968. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 25: 192-205.
20. Shian, W. M., Sasaki, I., Kamiyama, Y., Naito, H., Matsuno, S. and Miyazawa, T. 2000. The role of lipid peroxidation on gastric mucosal lesions induced by water-immersion-restraint stress in rats. Surg. Today 30: 49-53.
21. Shimizu, I. 2000. Sho-saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma. Eur. J. Gastroenterol. Hepatol. 15: D84-90.
22. Silen, W., Merhav, A. and Simson, J. 1981. The pathophysiology of stress ulcer disease. World J. Surg. 5: 165-174.
23. Stein, H. J., Hinder, R. A. and Oosthuizen, N. M. J. 1990. Gastric mucosal injury caused by hemorrhagic shock and reperfusion: protection role of the antioxidant glutathione. Surgery 108: 467-474.
24. Su, S. B., Motoo, Y., Iovanna, J. L., Xie, M. J., Taga, H. and Sawabu, N. 2001. Antifibrotic effect of the herbal medicine Saiko-keishi-to (TJ-10) on chronic pancreatitis in the WBN/Kob rat. Pancreas 22: 8-17.
25. Sugaya, E., Sugaya, A., Kajiwara, K., Yuyama, N., Tsuda, T., Motoki, M., Shimizu Nishikawa, K. and Kimura, M. 1997. Nervous diseases and Kampo (Japanese herbal) medicine: a new paradigm of therapy against intractable nervous diseases. Brain Dev. 19: 93-103.
26. Takagi, K. and Okabe, S. 1968. The effects of drugs on the stress ulcer in rats. Jpn. J. Pharmacol. 18: 9-18.
27. Uramoto, H., Ohno, T. and Ishihara, T. 1990. Gastric mucosal protection induced by restraint and water-immersion stress in rats. Jpn. J. Pharmacol. 54: 287-298.
28. Uteshev, N. S., Pakhomova, G. V., Tveritneva, L. F., Lebedev, A. G., Matveev, S. B., Marchenko, V. V. and Golikov, P. P. 1999. Lipid peroxidation and antioxidant system functions in patients with gastroduodenal ulcerous hemorrhages undergoing conservative and surgical treatment. Vestn. Khir. Im. I. I. Grek. 158: 24-26.
29. Yabana, T. and Yachi, A. 1988. Stress-induced vascular damage and ulcer. Dig. Dis. Sci. 33: 751-761.
30. Yamahara, J., Mochizuki, M., Rong, H. Q., Matsuda, H. and Fujimura, H. 1988. The anti-ulcer effect in rats of ginger constituents. J. Ethnopharmacol. 23: 299-304.
31. Yasukawa, K., Kasazaki, K., Hyodo, F. and Utsumi, H. 2004. Non-invasive analysis of reactive oxygen species generated in rats with water immersion sestraint-induced gastric lesions using in vivo electron spin resonance spectroscopy. Free Radic. Res. 38: 147-155.
32. Yokozawa, T., Liu, Z. W. and Chen, C. P. 2000. Protective effects of Glycyrrhizae radix extract and its compounds in a renal hypoxia (ischemia)-reoxygenation (reperfusion) model. Phytomedicine 6: 439-445.
33. Yoshikawa, T., Miyazawa, H., Yoshida, N., Sugino, S. and Kondo, M. 1986. Increase in lipid peroxidation in rat gastric musical lesions induced by water-immersion restraint stress. J. Clin. Biochem. Nutr. 1: 271-277.
34. Yoshikawa, T., Takahashi, S. and Kondo, M. 1991. Oxygen derived free radical and traditional Kampo medicines. Rec. Adv. Cardiovasc. Dis. 12: 173-181.