The relationship between alexithymia and circulating cytokine levels in subjects undergoing upper endoscopy

NeuroImmunoModulation

Volumn 18, Issue 1, 2010, Pages 37-44

  Mandarelli, Gabriele ^a   Tarsitani, Lorenzo ^a   Ippoliti, Flora ^b   Covotta, Francesco ^a   Zerella, Maria Paola ^a   Mirigliani, Alessia ^a   Biondi, Massimo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Department of Experimental Medicine and Pathology ^*  (Italy)

Author keywords

Alexithymia; Cytokines; Stress; Upper endoscopy

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ADULT; ALEXITHYMIA; ANXIETY; ARTICLE; CLINICAL ARTICLE; CONFOUNDING VARIABLE; CONTROLLED STUDY; DEPRESSION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GASTROINTESTINAL ENDOSCOPY; HOSPITAL ANXIETY AND DEPRESSION SCALE; HUMAN; MALE; MULTIPLE LINEAR REGRESSION ANALYSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STRESS; UPPER GASTROINTESTINAL TRACT;

ADULT; AFFECTIVE SYMPTOMS; CROSS-SECTIONAL STUDIES; CYTOKINES; ENDOSCOPY, DIGESTIVE SYSTEM; FEMALE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-1BETA; INTERLEUKIN-4; INTERLEUKIN-6; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; STRESS, PSYCHOLOGICAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77954256644     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000315529     Document Type: Article

References (41)

1. Irwin M: Immune correlates of depression; in Dantzer R, Wollman EE, Yirmiya R (eds): Cytokines, Stress, and Depression. New York, Kluwer Academic/Plenum, 1999, pp 1-24.
2. Maes M: Evidence for an immune response in major depression: a review and hypothe-sis. Prog Neuropsychopharmacol Biol Psy-chiatry 1995; 19: 11-38.
3. Koh KB, Lee BK: Reduced lymphocyte pro-liferation and interleukin-2 production in anxiety disorders. Psychosom Med 1998; 60: 479-483.
4. Rapaport MH: Circulating lymphocyte phe-notypic surface markers in anxiety disorder patients and normal volunteers. Biol Psychiatry 1998; 43:458-463.
5. Segerstrom SC, Miller GE: Psychological stress and the human immune system: a me-ta-analytic study of 30 years of inquiry. Psychol Bull 2004; 130: 601-630.
6. Biondi M: Effects of stress on immune func-tions: an overview; in Ader R, Felten DL, Co-hen N (eds): Psychoneuroimmunology, ed 3. San Diego, Academic Press, 2001, vol 2, pp 189-226.
7. Vollrath M: Personality and stress. Scand J Psychol 2001; 42:335-347.
8. Kemeny ME, Laudenslager ML: Beyond stress: the role of individual difference fac-tors in psychoneuroimmunology. Brain Be-hav Immun 1999; 13: 73-75.
9. Kemeny ME: Psychoneuroimmunology; in Friedman HS, Silver RC (eds): Foundations of Health Psychology. New York, Oxford University Press, 2007, pp 92-116.
10. Picardi A, Battisti F, Tarsitani L, Baldassarri M, Copertaro A, Mocchegiani E, Biondi M: Attachment security and immunity. A pilot study. Psychosom Med 2007; 69:40-46.
11. Friedman, HS: The multiple linkages of per-sonality and disease. Brain Behav Immun 2008; 22:668-675.
12. Sifneos PE: The prevalence of 'alexithymic' characteristics in psychosomatic patients. Psychother Psychosom 1973; 22:255-262.
13. Taylor GJ, Bagby RM, Parker JDA: Disorders of Affect Regulation: Alexithymia In Medi-cal and Psychiatric Illness. Cambridge, Cambridge University Press, 1997.
14. Taylor GJ, Bagby RM: New trends in alexi-thymia research. Psychother Psychosom 2004; 73: 68-77.
15. Guilbaud O, Corcos M, Hjalmarsson L, Loas G, Jeammet P: Is there a psychoneuroImmunological pathway between alexithymia and immunity? Immune and physiological cor-relates of alexithymia. Biomed Pharmaco-ther 2003; 57: 292-295.
16. Guilbaud O, Curt F, Perrin C, Chaouat G, Berthoz S, Dugré-Le Bigre C, Wallier J, Stre-bler M, Touitou C, Jeammet P, Corcos M: De-creased immune response in alexithymic women: a cross-sectional study. Biomed Pharmacother 2009; 63:297-304.
17. Todarello O, Casamassima A, Marinaccio M, La Pesa MW, Caradonna L, Valentino L, Marinaccio L: Alexithymia, immunity and cervical intraepithelial neoplasia: a pilot study. Psychother Psychosom 1994; 61: 199-204.
18. Todarello O, Casamassima A, Daniele S, Marinaccio M, Fanciullo F, Valentino L, Te-desco N, Wiesel S, Simone G, Marinaccio L: Alexithymia, immunity and cervical in-traepithelial neoplasia: replication. Psycho-ther Psychosom 1997; 66:208-213.
19. Dewaraja R, Tanigawa T, Araki S, Nakata A, Kawamura N, Ago Y, Sasaki Y: Decreased cy-totoxic lymphocyte counts in alexithymia. Psychother Psychosom 1997; 66: 83-86.
20. Shea JD, Burton R, Girgis A: Negative affect, absorption, and immunity. Physiol Behav 1993; 53: 449-457.
21. Temoshok LR, Waldstein SR, Wald RL, Gar-zino-Demo A, Synowski SJ, Sun L, Wiley JA: Type C coping, alexithymia, and heart rate reactivity are associated independently and differentially with specific immune mecha-nisms linked to HIV progression. Brain Be-hav Immun 2008; 22:781-792.
22. Corcos M, Guilbaud O, Paterniti S, Curt F, Hjalmarsson L, Moussa M, Chambry J, Loas G, Chaouat G, Jeammet P: Correlation be-tween serum levels of interleukin-4 and alex-ithymia scores in healthy female subjects: preliminary findings. Psychoneuroendocri-nology 2004; 29:686-691. (Pubitemid 38369169)
23. Pedrosa Gil F, Nickel M, Ridout N, Schwarz MJ, Schoechlin C, Schmidmaier R: Alexi-thymia and interleukin variations in so-matoform disorder. Neuroimmunomodula-tion 2007; 14: 235-242.
24. Bruni R, Serino FM, Galluzzo S, Coppolino G, Cacciapaglia F, Vadacca M, Nilo S, Termi-nio N, Afeltra A: Alexithymia and neuroen-docrine-immune response in patients with autoimmune diseases: preliminary results on relationship between alexithymic con-struct and TNF-alpha levels. Ann NY Acad Sci 2006; 1069:208-211.
25. Spivak B, Shohat B, Mester R, Avraham S, Gil-Ad I, Bleich A, Valevski A, Weizman A: Elevated levels of serum interleukin-1 beta in combat-related posttraumatic stress disor-der. Biol Psychiatry 1997; 42:345-348.
26. Koh KB, Choe E, Song JE, Lee EH: Effect of coping on endocrinoimmune functions in different stress situations. Psychiatry Res 2006; 143: 223-234.
27. Martin JB, Pihl RO: Influence of alexithymic characteristics on physiological and subjec-tive stress responses in normal individuals. Psychother Psychosom 1986; 45:66-77.
28. Martin JB, Pihl RO: The stress-alexithymia hypothesis: theoretical and empirical con-siderations. Psychother Psychosom 1985; 43: 169-176.
29. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4. Washington DC, American Psychiatric Association, 1994.
30. Bressi C, Taylor G, Parker J, Bressi S, Bram-billa V, Aguglia E, Allegranti I, Bongiorno A, Giberti F, Bucca M, Todarello O, Callegari C, Vender S, Gala C, Invernizzi G: Cross valida-tion of the factor structure of the 20-item To-ronto Alexithymia Scale: an Italian multi-center study. J Psychosom Res 1996; 41: 551-559.
31. Porcelli P, Bagby RM, Taylor GJ, De Carne M, Leandro G, Todarello O: Alexithymia as predictor of treatment outcome in patients with functional gastrointestinal disorders. Psychosom Med 2003; 65:911-918.
32. Zigmond AS, Snaith RP: The hospital anxi-ety and depression scale. Acta Psychiatr Scand 1983; 67:361-370.
33. Tarsitani L, Battisti F, Biondi M, Picardi A: Development and validation of a Stress-re-lated Vulnerability Scale. Epidemiol Psichi-atr Soc 2010; 19: 169-172.
34. Kirk RE: Experimental design: procedures for the behavioral sciences. Belmont, Brooks/ Cole Publishing, 1968.
35. Van Kerkhoven LA, Van Rossum LG, Van Oijen MG, Tan AC, Witteman EM, Laheij RJ, Jansen JB: Alexithymia is associated with gastrointestinal symptoms, but does not pre-dict endoscopy outcome in patients with gas-trointestinal symptoms. J Clin Gastroenterol 2006; 40: 195-199.
36. Picardi A, Toni A, Caroppo E: Stability of alexithymia and its relationships with the 'big five' factors, temperament, character, and attachment style. Psychother Psycho-som 2005; 74:371-378.
37. Sorrells SF, Sapolsky RM: An inflammatory review of glucocorticoid actions in the CNS. Brain Behav Immun 2007; 21:259-272.
38. Elenkov IJ: Systemic stress-induced Th2 shift and its clinical implications. Int Rev Neurobiol 2002; 52: 163-186.
39. Akira S, Hirano T, Taga T, Kishimoto T: Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J 1990; 4:2860-2867.
40. Heinrich PC, Castell JV, Andus T: Interleu-kin-6 and the acute phase response. Biochem J 1990; 265: 621-636.
41. Bossù P, Salani F, Cacciari C, Picchetto L, Cao M, Bizzoni F, Rasura M, Caltagirone C, Robinson RG, Orzi F, Spalletta G: Disease outcome, alexithymia and depression are differently associated with serum IL-18 lev-els in acute stroke. Curr Neurovasc Res 2009; 6: 163-170.