Valproate treatment of human cord blood CD4-positive effector T cells confers on them the molecular profile (microRNA signature and FOXP3 expression) of natural regulatory CD4-positive cells through inhibition of histone deacetylase

Journal of Biological Chemistry

Volumn 285, Issue 27, 2010, Pages 20481-20491

  Fayyad Kazan, Hussein ^a   Rouas, Redouane ^a   Merimi, Makram ^a   El Zein, Nabil ^a   Lewalle, Philippe ^a   Jebbawi, Fadi ^a   Mourtada, Mohamad ^b   Badran, Hussein ^b   Ezzeddine, Mohamad ^b   Salaun, Bruno ^c   Romero, Pedro ^c   Burny, Arsène ^a   Martiat, Philippe ^a   Badran, Bassam ^b  

^a JULES BORDET INSTITUTE   (Belgium)

^b LEBANESE UNIVERSITY   (Lebanon)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; AMINO ACIDS; CYTOLOGY; IMMUNE SYSTEM; PROTEINS; RNA;

ACTIVATING TRANSCRIPTION FACTOR; ADDITIVE EFFECTS; DEACETYLASE INHIBITOR; EXPRESSION LEVELS; EXPRESSION PROFILE; HISTONE DEACETYLASES; LENTIVIRAL EXPRESSION; REGULATORY T CELLS;

T-CELLS;

CD4 ANTIGEN; HISTONE DEACETYLASE; HISTONE H4; LYSINE; MICRORNA; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR ETS 2; TRANSCRIPTION FACTOR FOXP3; VALPROIC ACID;

ACETYLATION; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CHROMATIN; CONTROLLED STUDY; EFFECTOR CELL; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY T LYMPHOCYTE;

EID: 77954234137     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.119628     Document Type: Article

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