Target identification: HIF2α central player in osteoarthritis

Nature Reviews Drug Discovery

Volumn 9, Issue 7, 2010, Pages 517-

  Flemming, Alexandra ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 2ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ARTICLE; CARTILAGE CELL; CHONDROPATHY; DISEASE ACTIVITY; DISEASE COURSE; ENCHONDRAL OSSIFICATION; EXTRACELLULAR MATRIX; HETEROZYGOTE; HOMOZYGOTE; HUMAN; KNEE ARTHROPLASTY; KNEE OSTEOARTHRITIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SYMPTOM;

EID: 77954232388     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd3210     Document Type: Article

References (2)

1. Yang, S. et al. Hypoxia-inducible factor-2á is a catabolic regulator of osteoarthritic cartilage destruction. Nature Med. 16, 687-693 (2010)
2. Saito, T. et al. Transcriptional regulation of endochondral ossification by HIF-2á during skeletal growth and osteoarthritis development. Nature Med. 16, 678-686 (2010)