Tricyclic sulfones as orally active γ-secretase inhibitors: Synthesis and structure-activity relationship studies

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 12, 2010, Pages 3632-3635

  Sasikumar, T K ^a   Qiang, Li ^a   Burnett, Duane A ^a   Cole, David ^a   Xu, Ruo ^a   Li, Hongmei ^a   Greenlee, William J ^a   Clader, John ^a   Zhang, Lili ^a   Hyde, Lynn ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Secretase; Alzheimer's disease; Sulfone

Indexed keywords

GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; SULFONAMIDE; SULFONE DERIVATIVE; TRICYCLIC SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPETITIVE INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; DRUG TOLERABILITY; IN VIVO STUDY; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN CHEMISTRY; MICE; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; SULFONES;

EID: 77954213459     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.104     Document Type: Article

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