Combined immunoelectron microscopic and computer-assisted image analyses to detect advanced glycation end-products in human myocardium

Histochemistry and Cell Biology

Volumn 134, Issue 1, 2010, Pages 23-30

  Donaldson, Cameron ^a   Taatjes, Douglas J ^a   Zile, Michael ^b   Palmer, Bradley ^a   Vanburen, Peter ^a   Spinale, Francis ^b   Maughan, David ^a   Von Turkovich, Michele ^a   Bishop, Nicole ^a   LeWinter, Martin M ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Advanced glycation end products; Diabetes mellitus; Immunoelectron microscopy; Myocardium

Indexed keywords

6 N CARBOXYMETHYLLYSINE; ADVANCED GLYCATION END PRODUCT; BOVINE SERUM ALBUMIN; COLLOIDAL GOLD; MONOCLONAL ANTIBODY;

ADULT; AGED; ANTIBODY LABELING; ANTIGEN ANTIBODY COMPLEX; ARTERY WALL; ARTICLE; CELL FUNCTION; CLINICAL ARTICLE; COMPUTER ANALYSIS; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; DIABETES MELLITUS; ENDOTHELIUM CELL; ENERGY METABOLISM; FEMALE; HEART MUSCLE BIOPSY; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTENSION; IMAGE ANALYSIS; IMMUNOELECTRON MICROSCOPY; MALE; MICROSCOPY; MITOCHONDRION; MYOFILAMENT; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

COLLOIDS; CORONARY ARTERY BYPASS; FEMALE; GLYCOSYLATION END PRODUCTS, ADVANCED; GOLD; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LYSINE; MALE; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; MYOCARDIUM; PARTICLE SIZE; SURFACE PROPERTIES;

BOVINAE;

EID: 77954212461     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-010-0706-x     Document Type: Article

References (45)

1. D Aronson 2003 Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes J Hypertens 21 3 12 10.1097/00004872-200301000-00002 1:CAS:528:DC%2BD3sXlsVyqtw%3D%3D 12544424 (Pubitemid 36143498)
2. NC Avery AJ Bailey 2006 The effects of the Maillard reaction on the physical properties and cell interactions of collagen Pathol Biol 54 7 387 395 10.1016/j.patbio.2006.07.005 1:CAS:528:DC%2BD28XhtVagtr3K 16962252 (Pubitemid 44442672)
3. TJ Berg O Snorgaard J Faber PA Torjesen P Hildebrandt J Mehlsen KF Hanssen 1999 Serum levels of advanced glycation end products are associated with left ventricular diastolic function in patients with type 1 diabetes Diabetes Care 22 1186 1190 10.2337/diacare.22.7.1186 1:STN:280:DyaK1Mzhslaiug%3D%3D 10388987 (Pubitemid 29293975)
4. R Candido JM Forbes MC Thomas V Thallas RG Dean WC Burns C Tikellis RH Ritchie SM Twigg ME Cooper LM Burrell 2003 A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes Circ Res 92 7 785 792 10.1161/01.RES.0000065620.39919.20 1:CAS:528:DC%2BD3sXislCgtbg%3D 12623881 (Pubitemid 36457644)
5. E Carlemalm RM Garavito W Villiger 1982 Resin development for electron microscopy and an analysis of embedding at low temperature J Microsc 126 123 143 1:CAS:528:DyaL38XltVKnsr0%3D (Pubitemid 12066550)
6. J Chen M Song S Yu P Gao Y Yu H Wang L Huang 2010 Advanced glycation endproducts alter functions and promote apoptosis in endothelial progenitor cells through receptor for advanced glycation endproducts mediate overpression of cell oxidant stress Mol Cell Biochem 335 1-2 137 146 10.1007/s11010-009-0250- y 1:CAS:528:DC%2BC3cXovVCksA%3D%3D 19756958
7. ME Cooper 2004 Importance of advanced glycation end products in diabetes-associated cardiovascular and renal disease Am J Hypertens 17 31S 38S 10.1016/j.amjhyper.2004.08.021 1:CAS:528:DC%2BD2cXhtVyqsrjM 15607433 (Pubitemid 39647569)
8. JC Fanburg AE Rosenberg DL Weaver KO Leslie KG Mann DJ Taatjes RP Tracy 1997 Osteocalcin and osteonectin immunoreactivity in the diagnosis of osteosarcoma Am J Clin Pathol 107 464 473
9. NK Fukagawa BM Palmer WD Barnes BJ Leavitt FP Ittleman MM Lewinter DW Maughan 2005 Acto-myosin crossbridge kinetics in humans with coronary artery disease: influence of sex and diabetes mellitus J Mol Cell Cardiol 39 5 743 753 10.1016/j.yjmcc.2005.06.010 1:CAS:528:DC%2BD2MXhtFCjsLbM 16171812 (Pubitemid 41464411)
10. K Ikeda T Higashi H Sano Y Jinnouchi M Yoshida T Araki S Ueda S Horiuchi 1996 N (Carboxymethyl) lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reaction Biochemistry 35 8075 8083 10.1021/bi9530550 1:CAS:528:DyaK28XjtF2jt7w%3D 8672512 (Pubitemid 26202550)
11. DA Kass EP Shapiro M Kawaguchi AR Capriotti A Scuteri RC Degroof EG Lakatta 2001 Improved arterial compliance by a novel advanced glycation end-product crosslink breaker Circulation 104 1464 1470 10.1161/hc3801.097806 1:CAS:528:DC%2BD3MXnvVeqtLY%3D 11571237
12. W Kim BJ Hudson B Moser J Guo LL Rong Y Lu W Qu E Lalla S Lerner Y Chen SS Yan V D'Agati Y Naka R Ramasamy K Herold SF Yan AM Schmidt 2005 Receptor for advanced glycation end products and its ligands: a journey from the complications of diabetes to its pathogenesis Ann N Y Acad Sci 1043 553 561 10.1196/annals.1338.063 1:CAS:528:DC%2BD2MXpvVKqtLY%3D 16037278 (Pubitemid 41123945)
13. SY Li M Du EK Dolence CX Fang GE Mayer AF Ceylan-Isik KH LaCour X Yang CJ Wilbert N Sreejayan J Ren 2005 Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification Aging Cell 4 57 64 10.1111/j.1474-9728.2005.00146.x 1:CAS:528:DC%2BD2MXjtFCgtLc%3D 15771609 (Pubitemid 41632904)
14. WC Little MR Zile DW Kitzman WG Hundley TX O'Brien RC Degroof 2005 The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure J Card Fail 11 191 195 10.1016/j.cardfail.2004.09.010 1:CAS:528:DC%2BD2MXivV2isb8%3D 15812746 (Pubitemid 40462421)
15. R Meerwaldt HL Lutgers TP Links R Graaff JW Baynes RO Gans AJ Smit 2007 Skin autofluorescence is a strong predictor of cardiac mortality in diabetes Diabetes Care 30 1 107 112 10.2337/dc06-1391 1:CAS:528:DC%2BD2sXhsFWqtb0%3D 17192342 (Pubitemid 46052507)
16. SL Mount DJ Taatjes 1994 Neuroendocrine carcinoma of the skin (Merkel cell carcinoma): an immunoelectron microscopic case study Am J Dermatopathol 16 60 65 10.1097/00000372-199402000-00012 1:STN:280:DyaK2c3htlWrug%3D%3D 7512800
17. SL Mount DJ Taatjes TD Trainer 1993 Ultrastructural study of a pituitary adenoma (prolactinoma) within the clivus bone using immunoelectron microscopy Ultrastruct Pathol 17 639 664 10.3109/01913129309027799
18. SL Mount DJ Taatjes M von Turkovich BH Tindle TD Trainer 1993 Diagnostic immunoelectron microscopy in surgical pathology: assessment of various tissue fixation and processing protocols Ultrastruct Pathol 17 547 557 10.3109/01913129309027799 1:STN:280:DyaK2c%2FnvVentw%3D%3D 7504845
19. SL Mount KR Lee DJ Taatjes 1995 Carcinosarcoma (malignant mixed mullerian tumor) of the uterus with a rhabdoid tumor component: an immunohistochemical, ultrastructural and immunoelectron microscopic case study Am J Clin Pathol 103 235 239 1:STN:280:DyaK2M7lvF2nsw%3D%3D 7856569
20. SL Mount DL Weaver DJ Taatjes WC McKinnon JC Hebert 1995 Von Hippel-Lindau disease presenting as pancreatic neuroendocrine tumor Virchows Arch A Pathol Anat 426 523 528 1:STN:280:DyaK2MzmtVaktA%3D%3D
21. SL Mount J Dickerman DJ Taatjes 1996 Extrarenal Wilm's tumor: an ultrastructural and immunoelectron microscopic case report Ultrastruct Pathol 20 155 165 10.3109/01913129609016310 1:STN:280:DyaK2s%2Fjs1Oitg%3D%3D 8882361
22. Y Naka LG Bucciarelli T Wendt LK Lee LL Rong R Ramasamy SF Yan AM Schmidt 2004 RAGE axis: animal models and novel insights into the vascular complications of diabetes Arterioscler Thromb Vasc Biol 24 1342 1349 10.1161/01.ATV.0000133191.71196.90 1:CAS:528:DC%2BD2cXmtValtL4%3D 15155381 (Pubitemid 39050425)
23. Y Nakamura Y Horii T Nishino H Shiiki Y Sakaguchi T Kagoshima K Dohi Z Makita H Vlassara R Buccala 1993 Immunohistochemical localization of advanced glycosylation end products in coronary atheroma and cardiac tissue in diabetes mellitus Am J Pathol 143 1649 1656 1:STN:280:DyaK2c%2FnvFSnsA%3D%3D 8256853
24. S Ohno HJ Im CB Knudson W Knudson 2006 Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes J Biol Chem 281 17952 17960 10.1074/jbc.M602750200 1:CAS:528:DC%2BD28XmtFykt7s%3D 16648633 (Pubitemid 44035594)
25. J Roth M Bendayan L Orci 1978 Ultrastructural localization of intracellular antigens by the use of protein A-gold complex J Histochem Cytochem 26 1074 1081 1:CAS:528:DyaE1MXhvVOjuw%3D%3D 366014
26. J Roth M Bendayan E Carlemalm W Villiger M Garavito 1981 Enhancement of structural preservation and immunocytochemical staining in low temperature embedded pancreatic tissue J Histochem Cytochem 29 663 671 1:STN:280: DyaL3M3ktVOjsg%3D%3D 6166664
27. S Schafer J Huber XC Wihler H Rutten AE Busch W Linz 2006 Impaired left ventricular relaxation in type 2 diabetic rats is related to myocardial accumulation of N(epsilon)-(carboxymethyl) lysine Eur J Heart Fail 8 206
28. BP Shapiro TE Owan SF Mohammed DM Meyer LD Mills CG Schalkwijk MM Redfield 2008 Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines Circulation 118 10 1002 1010 10.1161/CIRCULATIONAHA.108. 777326 1:CAS:528:DC%2BD1cXhtVejsL3L 18711013
29. A Simm B Bartling RE Silber 2004 RAGE: a new pleiotropic antagonistic gene? Ann N Y Acad Sci 1019 228 231 10.1196/annals.1297.038 1:CAS:528: DC%2BD2cXms12gur8%3D 15247020 (Pubitemid 38951311)
30. AJ Smit HL Lutgers 2004 The clinical relevance of advanced glycation endproducts (AGE) and recent developments in pharmaceutics to reduce AGE accumulation Curr Med Chem 11 2767 2784 1:CAS:528:DC%2BD2cXns1Sku7k%3D 15544475
31. DJ Taatjes B Arendash-Durand M von Turkovich TD Trainer 1993 HMB-45 antibody demonstrates melanosome-specificity by immunoelectron microscopy Arch Pathol Lab Med 117 264 268 1:STN:280:DyaK3s7otlSmtg%3D%3D 8442672
32. DJ Taatjes SL Mount TD Trainer BH Tindle 1994 Localization of anti Leu-M1 (CD15) binding sites in Hodgkin's disease by immunoelectron microscopic examination Am J Clin Pathol 101 140 148 1:STN:280:DyaK2c7mtV2nsg%3D%3D 8116567
33. KC Tan WS Chow VH Ai C Metz R Bucala KS Lam 2002 Advanced glycation end products and endothelial dysfunction in type 2 diabetes Diabetes Care 25 1055 1059 10.2337/diacare.25.6.1055 1:CAS:528:DC%2BD38XkslSksLY%3D 12032114 (Pubitemid 41110493)
34. PJ Thormally 2005 Dicarbonyl intermediates in the Maillard reaction Ann N Y Acad Sci 1043 111 117 10.1196/annals.1333.014 (Pubitemid 41123896)
35. P Ulrich A Cerami 2001 Protein glycation, diabetes, and aging Endocr Soc 56 1 21 1:CAS:528:DC%2BD3MXitV2lurg%3D
36. AM Valente DJ Taatjes SL Mount 1995 Comparison of the pattern of expression of Leu-M1 antigen in adenocarcinomas, neutrophils and Hodgkin's disease by immunoelectron microscopy Histochemistry 103 181 186 10.1007/BF01454022 1:CAS:528:DyaK2MXkslSrsLg%3D 7553131
37. L van Heerebeek N Hamdani ML Handoko I Falcao-Pires RJ Musters K Kupreishvili AJ Ijsselmuiden CG Schalkwijk JG Bronzwaer M Diamont A Borbely J van der Velden GJ Stienen GJ Laarman HW Niessen WJ Paulus 2008 Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension Circulation 117 43 51 10.1161/CIRCULATIONAHA.107.728550 18071071 (Pubitemid 350291180)
38. JL Wautier AM Schmidt 2004 Protein glycation: a firm link to endothelial cell dysfunction Circ Res 95 233 249 10.1161/01.RES.0000137876.28454.64 1:CAS:528:DC%2BD2cXmtValu78%3D 15297385 (Pubitemid 39056283)
39. JL Witztum EM Mahoney MJ Branks M Fisher R Elam D Steinberg 1982 Nonenzymatic glucosylation of low-density lipoprotein alters its biologic activity Diabetes 31 4 Pt 1 283 291 10.2337/diabetes.31.4.283 1:CAS:528:DyaL38XkslSgtLs%3D 6818075
40. SF Yan R Ramasamy Y Naka AM Schmidt 2003 Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond Circ Res 93 1159 1169 10.1161/01.RES.0000103862.26506.3D 1:CAS:528: DC%2BD3sXpsFymtLk%3D 14670831 (Pubitemid 37543056)
41. CH Yeh L Sturgis J Haidacher XN Zhang SJ Sherwood RJ Bjercke O Juhasz MT Crow RG Tilton L Denner 2001 Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional activation and cytokine secretion Diabetes 50 6 1495 1504 10.2337/diabetes.50.6. 1495 1:CAS:528:DC%2BD3MXkvFSgt78%3D 11375353
42. S Yoshida K Yamada K Hamaguchi M Nishimura E Hatakeyama H Tsuchida K Sakamoto H Kashiwabara T Yokoyama K Ikeda S Horiuchi 1998 Immunohistochemical study of human advanced glycation end-products (AGE) and growth factors in cardiac tissues of patients on maintenance dialysis and with kidney transplantation Clin Nephrol 49 273 280 1:CAS:528:DyaK1cXjt1Wnsrk%3D 9617488
43. N Yoshida K Okumura Y Aso 2005 High serum pentosidine concentrations are associated with increased arterial stiffness and thickness in patients with type 2 diabetes Metabolism 54 345 350 10.1016/j.metabol.2004.09.014 1:CAS:528:DC%2BD2MXhsVOjtLY%3D 15736112 (Pubitemid 40250094)
44. SJ Zieman V Melenovsky DA Kass 2005 Mechanisms, pathophysiology, and therapy of arterial stiffness Arterioscler Thromb Vasc Biol 25 932 943 10.1161/01.ATV.0000160548.78317.29 1:CAS:528:DC%2BD2MXjsVCjt7g%3D 15731494 (Pubitemid 40627836)
45. SJ Zieman V Melenovsky L Clattenburg MC Corretti A Capriotti G Gerstenblith DA Kass 2007 Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension J Hypertens 25 3 577 583 10.1097/HJH.0b013e328013e7dd 1:CAS:528:DC%2BD2sXhtlGqu7k%3D 17278974 (Pubitemid 46213796)