Hydrogel containing dexamethasone-loaded nanocapsules for cutaneous administration: Preparation, characterization, and in vitro drug release study

Drug Development and Industrial Pharmacy

Volumn 36, Issue 8, 2010, Pages 962-971

  Marchiori, M L ^a   Lubini, G ^a   Dalla Nora, G ^a   Friedrich, R B ^a   Fontana, M C ^a   Ourique, A F ^a   Bastos, M O ^a   Rigo, L A ^a   Silva, C B ^a   Tedesco, S B ^a   Beck, R C R ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Dexamethasone; Hydrogels; In vitro release; Nanocapsules

Indexed keywords

CARBOMER; DEXAMETHASONE; NANOCAPSULE; NANOPARTICLE; POLYMER; ANTIINFLAMMATORY AGENT; DRUG CARRIER; HYDROGEL; IMMUNOSUPPRESSIVE AGENT; SUSPENSION;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG FORMULATION; DRUG RELEASE; HYDROGEL; LIGHT SCATTERING; MERISTEM; MITOSIS INDEX; NONHUMAN; ONION; PARTICLE SIZE; PH; SKIN DISEASE; TOPICAL TREATMENT; TRANSMISSION ELECTRON MICROSCOPY; VISCOSITY; ZETA POTENTIAL; CELL CYCLE; CHEMISTRY; CYTOLOGY; DIFFUSION; DRUG EFFECTS; INTRADERMAL DRUG ADMINISTRATION; MITOSIS; PHYSICAL CHEMISTRY; PLANT ROOT; PROCEDURES; SOLUBILITY; SUSPENSION; SYNTHESIS;

ADMINISTRATION, CUTANEOUS; ANTI-INFLAMMATORY AGENTS; CELL CYCLE; CELL PROLIFERATION; DEXAMETHASONE; DIFFUSION; DRUG CARRIERS; DRUG COMPOUNDING; HYDROGELS; HYDROGEN-ION CONCENTRATION; IMMUNOSUPPRESSIVE AGENTS; MERISTEM; MITOSIS; NANOCAPSULES; ONIONS; PARTICLE SIZE; PHYSICOCHEMICAL PHENOMENA; PLANT ROOTS; SOLUBILITY; SUSPENSIONS;

EID: 77954199997     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639041003598960     Document Type: Article

References (48)

1. Sahoo SK, Labhasetwar V. (2003). Nanotech approaches to delivery and imaging drug. Drug Discov Today, 8:1112-1120
2. Rawat M, Singh D, Saraf S, Saraf S. (2006). Nanocarriers: Promising vehicle for bioactive drugs. Biol Pharm Bull, 29:1790-1798
3. Devalapally H, Chakilam A, Amiji MM. (2007). Role of nanotechnology in pharmaceutical product development. J. Pharm Sci, 96:2547-2565
4. Alonso MJ. (2004). Nanomedicines for overcoming biological barriers. Biomed Pharmacother, 58:168-172
5. Guterres SS, Alves MP, Pohlmann AR. (2007). Polymeric nano-particles, nanospheres and nanocapsules, for cutaneous applications. Drug Target Insights, 2:147-157
6. Ourique AF, Pohlmann AR, Guterres SS, Beck RCR. (2008). Tretinoin-loaded nanocapsules: Preparation, physicochemi-cal characterization, and photostability study. Int J Pharm, 352:1-4.
7. Fontana MC, Coradini K, Guterres SS, Pohlmann AR, Beck RCR. (2009). Nanoencapsulation as a way to control the release and to increase the photostability of clobetasol propionate: Influence of the nanostructured system. J Biomed Nanotech-nol, 5:254-263
8. Almeida JS, Jezur L, Fontana MC, Paese K, Silva CB, Pohlmann AR, et al. (2009). Oil-based nanoparticles containing alternative vegetable oils (grape seed oil and almond kernel oil): Preparation and characterization. Latin Am J Pharm, 28:165-172
9. Alves MP, Scarrone AL, Santos M, Pohlmann AR, Guterres SS. (2007). Human skin penetration and distribution of nimesulide from hydrophilic gels containing nanocarriers. Int J Pharm, 341:215-220
10. Paese K, Jäger A, Poletto FS, Fonseca EP, Rossi-Bergmann B, Pohlmann AR, et al. (2009). Semisolid formulation containing a nanoencapsulated sunscreen: Effectiveness, in vitro photo-stability and immune response. J Biomed Nanotechnol, 5:240-246
11. Lademann J, Richter H, Teichmann A, Otberg N, Blume-peytavi U, Luengo J, et al. (2007). Nanoparticles\an efficient carrier for drug delivery into the hair follicles. Eur J Pharm Biopharm, 66:159-164
12. Jäger A, Stefani V, Guterres SS, Pohlmann AR. (2007). Physicol-chemical characterization of nanocapsule polymeric wall using fluorescent benvavole probes. Int J Pharm, 338:297-305.
13. Vauthier C, Bouchemal K. (2009). Preparation and manufacture of polymeric nanoparticles. Pharm Res, 25:1025-1058
14. Huynh NT, Passirani C, Saulnier P, Benoit JP. (2009). Lipid nanocapsules: A new platform for nanomedicine. Int J Pharm, 379:201-209
15. Alvarez-Roman R, Baorre G, Guy RH, Fessi H. (2001). Biodegradable polymer nanocapsules containing a sunscreen agent: Preparation and photoprotection. Eur J Pharm Biopharm, 52:191-195
16. Milão D, Knorst MT, Guterres SS. (2003). Hydrophilic gel containing nanocapsules of diclofenac: Development, stability study and physico-chemical characterization. Pharmazie, 58:325-329
17. Miyazaki S, Takahashi A, Kubo W. (2003). Poly-n-butylcy-anoacrilate (PNBCA) nanocapsules as a carrier for NSAID-s: In vitro release and in vivo skin penetration. J Pharm Sci, 6:240-245
18. Jiménez MM, Pelletier J, Bobin MF, Martini MC. (2004). Influence of encapsulation on the in vitro percutaneous absorption of octyl methoxycinnamate. Int J Pharm, 272:45-55.
19. Alves MP, Pohlmann AR, Guterres SS. (2005). Semisolid topical formulations containing nimesulide-loaded nanocapsules, nanospheres or nanoemulsion: Development and rheological characterization. Pharmazie, 60:900-904
20. Weisse S, Kalimouttou S, Lahiani-Skiba M, Djedaini-Pilard F, Perly B, Skiba M. (2009). Investigations on topically applied vitamin A loaded amphiphilic cyclodextrin nanocapsules. J Nanosci Nanotechnol, 9:640-645
21. Trautmann A, Akdis M, Schmid-Grendelmeier P, Disch, RBröcker EB, Blaser K, et al. (2001). Targeting keratinocyte apo-ptosis in the treatment of atopic dermatitis and allergic contact dermatitis. J Allergy Clin Immunol, 108:839-846 (Pubitemid 33096219)
22. Valencia IC, Kerdel FA. (2003). In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz S, eds. Fitzpatrick's dermatology in general medicine. Topical Glucocorticoids New York: McGraw-Hill Professional, 2585-2595
23. Zampieri N, Corroppolo M, Zuin V, Bianchi S, Camoglio FS. (2007). Phimosis and topical steroids: New clinical findings. Pediatr Surg Int, 23:331-335
24. Ahluwalia A. (1998). Topical glucocorticoids and the skin-mechanisms of action: An update. Mediators Inflamm, 7:183-193
25. Wiedersberg S, Leopold CS, Guy RH. (2008). Bioavailability and bioequivalence of topical glucocorticoids. Eur J Pharm Biopharm, 68:453-466
26. Kao JS, Fluhr JW, Man MQ, Fowler AJ, Hachem JP, Crumrine D, et al. (2003). Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: Inhibition of epidermal lipid synthesis account for functional abnormalities. J Invest Dermatol, 120:456-464
27. Friedrich RB, Fontana MC, Beck RCR, Pohlmann AR, Guterres SS. (2008). Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions. Quim Nova, 31:1131-1136
28. Fessi H, Puisieux F, Devissaguet JP. (1988). Procede de prépara-tion dês systèmes coloïdaux d'une substance sous forme de nanocapsules. European Patent 0274961, Al.
29. Patra J, Sahoo MK, Panda BB. (2005). Salicylic acid triggers genotoxic adaptation to methyl mercuric chloride and ethyl methane sulfonate, but not to maleic hydrazide in root meristem cells of Allium cepa L. Mutat Res-Gen Toxicol Environ, 581:173-180
30. Fachinetto JM, Ourique AF, Lubini G, Tedesco SB, Beck RCR. (2008). Tretinoin-loaded polymeric nanocapsules: Evaluation of the potential to improve the antiproliferative activities on Allium cepa root-tip compared to the free drug. Latin Am J Pharm, 27:668-673
31. ™ 10. Il Farmaco, 56:437-441
32. Borghetti GS, Knorst MT. (2006). Desenvolvimento e avaliação da estabilidade física de loções O/A contendo filtros solares. Rev Bras Cienc Farm, 42:531-537
33. Milan AL, Milão D, Souto AA, Corte TWF. (2007). Study of hydration skin by the cosmetics emulsions for xerosis and their stability by rheology. Rev Bras Cienc Farm, 43:649-657
34. Siepmann J, Peppas NA. (2001). Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev, 48:139-157
35. Quintanar-Guerrero D, Zorraquín-Cornejo BN, Ganem-Rondero A, Piñón-Segundo E, Nava-Arzaluz MG, Cornejo-Bravo JM. (2008). Controlled release of model substances from pH-sensitive hydrogels. J Mex Chem Soc, 52:272-278
36. Vicentini VEP, Camparoto ML, Teixeira RO, Mantovani MS. (2001). Averrhoa carambola L., Syzygium cumini (L.) Skeels and Cissus sicoydes L.: Medicinal herbal tea effects on vegetal and animal test systems. Acta Sci, 23:593-598
37. Teixeira RO, Camparoto ML, Mantovani MS, Vicentini VEP. (2003). Assessment of two medicinal plants, Psidium guajava L. and Achillea millefolium L. in in vivo assays. Genet Mol Biol, 26:551-555
38. Camparoto ML, Teixeira RO, Mantovani MS, Vicentini VEP. (2002). Effects of Maytenus ilicifolia Mart. and Bauhinia candi-cans Benth infusions on onion root-tip and rat bone-marrow cells. Genet Mol Biol, 25:85-89
39. Pinto-Alphandary H, Andremont A, Couvreur P. (2000). Targeted delivery of antibiotics using liposomes and nanoparti-cles: Research and applications. Int J Antimicrob Agents, 13:155-168
40. Brannon-Peppas L, Blanchette JO. (2004). Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev, 56:1649-1659
41. Leiferman KM, Schroeter A, Kirschner MK, Spelsberg TC. (1983). Characterization of the glucocorticoid receptor in human skin. J Invest Dermatol, 81:355-360
42. Kim MK, Choi SY. (2006). Evaluation of gender difference in skin type and pH. J Dermatol Sci, 41:153-156
43. Barreiro-Iglesias R, Alvarez-Lorenzo C, Concheiro A. (2001). Incorporation of small quantities of surfactants as a way to improve the rheological and diffusional behavior of carbopol gels. J Control Release, 77:59-75.
44. Garg A, Aggarwal D, Garg S, Singla A. (2002). Spreading of semisolid formulations. Pharm Technol, 26:84-105.
45. Contreras MD, Sanchez R. (2002). Application of factorial design to the study of the flow behavior, spreadability, transparency of Carbopol ETD 2020® gel. Part II. Int J Pharm, 234:149-157 (Pubitemid 34142620)
46. Huuskonen J, Solo M, Taskinen J. (1997). Neural network modeling for estimation of the aqueous solubility of structurally related drugs. J Pharm Sci, 86:450-454
47. Food and Drug Administration (FDA). U.S. Department of Health and Human Services. (1997). Guidance for industry: Nonsterile semisolid dosage forms. Scale-Up and postap-proval changes: Chemistry, manufacturing, and controls; In vitro release testing and in vivo bioequivalence documentation. http://www.fda.gov/downloads/Drugs/GuidanceCom-plianceRegulatoryInformation/ Guidances/UCM070930.pdf [accessed June 8, 2009].
48. Flynn GL, Shah PS, Tenjarla SN, Corbo M, DeMagistris D, Feld-man TG, et al. (1999). Assessment of value and applications of in vitro testing of topical dermatological drug products. Pharm Res, 16:1325-1330