Predicting post-translational lysine acetylation using support vector machines

Bioinformatics

Volumn 26, Issue 13, 2010, Pages 1666-1668

  Gnad, Florian ^a,b   Ren, Shubin ^a   Choudhary, Chunaram ^a,c   Cox, Jürgen ^a   Mann, Matthias ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

^c University of Copenhagen   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE; PROTEIN;

ACETYLATION; ALGORITHM; ARTICLE; HUMAN; METABOLISM; PROTEIN PROCESSING;

ACETYLATION; ALGORITHMS; HUMANS; LYSINE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS;

EID: 77954181419     PISSN: 13674803     EISSN: 14602059     Source Type: Journal    
DOI: 10.1093/bioinformatics/btq260     Document Type: Article

References (13)

1. Basu,A. et al. (2009) Proteome-wide prediction of acetylation substrates. Proc. Natl Acad. Sci. USA, 106, 13785-13790.
2. Blom,N. et al. (1999) Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J. Mol. Biol., 294, 1351-1362.
3. Choudhary,C. et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science, 325, 834-840.
4. Cohen,P. (2001) The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture. Eur. J. Biochem., 268, 5001-5010.
5. Gnad,F. et al. (2007) PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites. Genome Biol., 8, R250.
6. Gnad,F. et al. (2009) MAPU 2.0: high-accuracy proteomes mapped to genomes. Nucleic Acids Res., 37, D902-D906.
7. Hilger,M. et al. (2009) Systems-wide analysis of a phosphatase knock-down by quantitative proteomics and phosphoproteomics, Mol. Cell Proteomics, 8, 1908-1920.
8. Hunter,T. (2000) Signaling-2000 and beyond. Cell, 100, 113-127.
9. Li,S. et al. (2009) Improved prediction of lysine acetylation by support vector machines. Protein Pept. Lett., 16, 977-983.
10. Noble,W.S. (2006) What is a support vector machine? Nat. Biotechnol., 24, 1565-1567.
11. Obenauer,J.C. et al. (2003) Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Res., 31, 3635-3641.
12. Schwartz,D. et al. (2009) Predicting protein post-translational modifications using meta-analysis of proteome scale data sets. Mol. Cell Proteomics, 8, 365-379.
13. Zielinska,D.F. et al. (2009) Caenorhabditis elegans has a phosphoproteome atypical for metazoans that is enriched in developmental and sex determination proteins. J. Proteome Res., 8, 4039-4049.