Liquid chromatography-tandem mass spectrometric method for determination of E121 in mouse plasma and its application to pharmacokinetics

Journal of Separation Science

Volumn 33, Issue 13, 2010, Pages 1888-1896

  Matar, Kamal M ^a   El Hashim, Ahmed Z ^a   Edafiogho, Ivan O ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

E121; Enaminones; LC MS MS; Mouse plasma; Pharmacokinetics

Indexed keywords

ANALYTES; CALIBRATION STANDARD; DOSE RANGE; ENAMINONES; INTERNAL STANDARDS; INTRAPERITONEAL ADMINISTRATION; LC-MS/MS; LINEAR KINETICS; MATRIX EFFECTS; MOBILE PHASE; MOUSE PLASMA; TANDEM MASS SPECTROMETRIC;

AMMONIUM COMPOUNDS; LIQUID CHROMATOGRAPHY; PHARMACOKINETICS; PLASMAS;

PLASMA STABILITY;

ACETONITRILE; AMMONIUM ACETATE; ANTICONVULSIVE AGENT; E 118; E 121; ETHYL 4 [(4 CHLOROPHENYL)AMINO] 6 METHYL 2 OXO 3 CYCLOHEXENE 1 CARBOXYLIC ACID; FORMIC ACID; METHANOL; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; E 121 COMPOUND;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG STABILITY; FLOW RATE; LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ANIMAL; ANIMAL MODEL; BLOOD; CHEMICAL STRUCTURE; KINETICS; TISSUE DISTRIBUTION;

ANILINE COMPOUNDS; ANIMALS; CHROMATOGRAPHY, LIQUID; CYCLOHEXANECARBOXYLIC ACIDS; KINETICS; MICE; MODELS, ANIMAL; MOLECULAR STRUCTURE; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 77954162434     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200900800     Document Type: Article

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