Synergy between phenothiazines and oxacillin against clinical isolates of methicillin-resistant Staphylococcus aureus

Tropical Journal of Pharmaceutical Research

Volumn 9, Issue 3, 2010, Pages 243-249

  Hadji Nejad, Sanaz ^a   Rahbar, Mohammad ^b   Mehrgan, Hadi ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MINISTRY OF HEALTH AND MEDICAL EDUCATION   (Iran)

Author keywords

Methicillin resistance; Non antibiotics; Oxacillin; Phenothiazines; Staphylococcus aureus; Synergy

Indexed keywords

CHLORPROMAZINE; FLUPHENAZINE; OXACILLIN; PERPHENAZINE; PHENOTHIAZINE DERIVATIVE; PROMETHAZINE; THIETHYLPERAZINE; THIORIDAZINE; TRIFLUOPERAZINE;

ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN;

EID: 77954155740     PISSN: 15965996     EISSN: 15969827     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Kristiansen JE. Antimicrobial activity of non- antibiotics. Acta Path Microbiol Scand 1992; 100(Suppl.): 7-19.
2. Kristiansen MM, Leandro C, Ordway D, Martins M, Viveiros M, Pacheco T, Kristiansen JE, Amaral L. Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro. Int J Antimicrob Agents 2003; 22: 250-253.
3. Martins M, Bleiss W, Marko A, Ordway D, Viveiros M, Leandro C, Pacheco T, Molnár J, Kristiansen JE, Amaral L. Clinical concentrations of thioridazine enhance the killing of intracellular methicillin-resistant Staphylococcus aureus: an in vivo, ex vivo and electron microscopy study. In Vivo 2004; 18: 787-794.
4. Clinical and Laboratory Standards Institute (CLSI). Performance standards for antimicrobial susceptibility testing. Sixteenth informational supplement. Document M100-S16. Wayne, PA: CLSI, 2006.
5. Pillai SK.; Moellering RC. Eliopoulos George M. Antimicrobial combinations. In: Lorian Victor, editor. Antibiotics in laboratory medicine. 5th ed. Baltimore: Wlliams & Wilkins; 2005. p 365-441.
6. Basu LR, Mazumdar K, Dutta NK, Karak P, Dastidar SG. Antibacterial property of the antipyschotic agent prochlorperazine, and its synergism with methdilazine. Microbiol Res 2005; 160: 95-100.
7. Guttmann P, Ehrlich P. Über die Wirkung des Methylenblau bei Malaria. Berliner Klinische Wochenschrift 1891; 39: 953-956.
8. Kristiansen JE, Hendricks O, Delvin T, Butterworth TS, Aagaard L, Christensen JB, Flores VC, Keyzer K. Reversal of resistance in microorganisms by help of non-antibiotics. J Antimicrob Chemother 2007; 59: 1271-1279.
9. Mazumder R, Chaudhuri SR, Mazumdar A. Antimicrobial potentiality of a phenothiazine group of antipyschotic drug-prochlorperazine. Indian J Exp Biol 2002; 40: 828-830.
10. Hendricks O, Butterworth TS, Kristiansen JE. The in-vitro antimicrobial effect of non-antibiotics and putative inhibitors of efflux pumps on Pseudomonas aeruginosa and Staphylococcus aureus. Int J Antimicrob Agents 2003; 22: 262-264.
11. Kristiansen JE, Mortensen I. Antibacterial effect of four phenothiazines. Pharmacol Toxicol 1987; 60: 100-103.
12. Kaatz, GW, Mougdal VV, Seo SM, Kristiansen JE. Phenothiazines and thioxanthenes inhibit multidrug efflux pump activity in Staphylococcus aureus. Antimicrob Agents Chemother 2003, 47: 719-726.
13. -. J Bioenerg Biomembr 1995; 27: 127-136.
14. Piddock LJV. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev 2006; 19: 382-402.
15. Moffart, Anthony C., Ed., Clarke's isolation and identification of drugs. 2nd ed. London: The Pharmaceutical Press; 1986.
16. Ordway D, Viveiros M, Leandro C, Arroz MJ, Amaral L. Intracellular activity of clinical concentrations of phenothiazines including thioridazine against phagocytosed Staphylococcus aureus. Int J Antimicrob Agents 2002; 20: 34-43.
17. Svendsen CN, Froimowitz M, Hrbek C, Campbell A, Kula N, Baldessarini RJ, Cohen BM, Babb S, Teicher MH, Bird ED. Receptor affinity, neurochemistry and behavioral characteristics of the enantiomers of thioridazine: evidence for different stereoselectivities at D1 and D2 receptors in rat brain. Neuropharmacology 1988; 27: 1117-1124.
18. Pinho MG, Ludovice AM, Wu S, De Lencastre H. Massive reduction in methicillin resistance by transposon inactivation of the normal PBP2 in a methicillin-resistant strain of Staphylococcus aureus. Microb Drug Resist 1997; 3: 409-413.
19. Pinho MG, de Lencastre H, Tomasz A. An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci. Proc Natl Acad Sci USA 2001; 98: 10886-10891.
20. Amaral L, Viveiros M, Kristiansen JE. Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries. Trop Med Int Health 2001; 6: 1016-1022.
21. Klitgaard JK, Skov MN, Kallipolitis BH, Kolmos HJ. Reversal of methicillin resistance in Staphylococcus aureus by thioridazine. J Antimicrob Chemother 2008; 62: 1215-1221.