Validation of dose planning calculations for boron neutron capture therapy using cylindrical and anthropomorphic phantoms

Physics in Medicine and Biology

Volumn 55, Issue 12, 2010, Pages 3515-3533

  Koivunoro, Hanna ^a,b   Seppälä, Tiina ^a,b   Uusi Simola, Jouni ^a   Merimaa, Katja ^a   Kotiluoto, Petri ^c   Serén, Tom ^c   Kortesniemi, Mika ^a   Auterinen, Iiro ^c   Savolainen, Sauli ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHROPOMORPHIC PHANTOMS; BEAM MODEL; BORON NEUTRON CAPTURE THERAPY; CALCULATION ACCURACY; CELL SIZE; DEPTH DOSE; DOSE CALCULATION; DOSE MEASUREMENT; DOSE PLANNING; EPITHERMAL NEUTRON; FAST NEUTRONS; HEAD-AND-NECK CANCER; MCNP5 CALCULATIONS; MCNP5 CODES; NEUTRON ACTIVATION MEASUREMENTS; PHANTOM SURFACE; SIMULATION ENVIRONMENT; THERMAL NEUTRONS; TREATMENT PLANNING; TREATMENT PLANNING SYSTEMS; TWO BEAMS; WATER PHANTOM;

BORON; BORON COMPOUNDS; IONIZATION CHAMBERS; IONIZATION OF LIQUIDS; MANGANESE; MANGANESE COMPOUNDS; PARTICLE DETECTORS; PHOTOIONIZATION; PHOTONS; REACTION RATES;

NEUTRONS;

NITROGEN;

ARTICLE; COMPUTER ASSISTED RADIOTHERAPY; HUMAN; IMAGE QUALITY; INSTRUMENTATION; METHODOLOGY; MONTE CARLO METHOD; NEUTRON; NEUTRON CAPTURE THERAPY; PHOTON; RADIOMETRY; VALIDATION STUDY;

BORON NEUTRON CAPTURE THERAPY; HUMANS; MONTE CARLO METHOD; NEUTRONS; NITROGEN; PHANTOMS, IMAGING; PHOTONS; RADIOMETRY; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED;

EID: 77954153077     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/55/12/016     Document Type: Article

References (42)

1. Aarnio P, Nikkinen M and Routti J 1999 SAMPO Advanced Gamma Spectrum Analysis Software, Version 4.00, User's Guide (Helsinki: Logion Oy)
2. Albritton J R and Kiger W S 2006 Development of reference problems for neutron capture therapy treatment planning systems Advances in Neutron Capture Therapy 2006 Proc ICNCT-12 pp 496-9
3. Auterinen I 2007 Experience with a modern BNCT facility at the 250 kW FiR Triga research reactor utilization related design features of research reactors: a compendium IAEA Technical Reports Series No 455 (Vienna: International Atomic Energy Agency (IAEA)) pp 253-74
4. Auterinen I, Serén T, Kotiluoto P, Uusi-Simola J and Savolainen S 2004 Quality assurance procedures for the neutron beam monitors at the FiR 1 BNCT facility Appl. Radiat. Isot. 61 1015-9
5. Binns P J, et al. 2005 An international dosimetry exchange for boron neutron capture therapy: part I. Absorbed dose measurements Med. Phys. 32 3729-36
6. Briesmeister J F 2000 MCNP-A General Monte Carlo Code N-Particle Transport Code version 4C LA-13709-M
7. Broerse J J, Mijnheer B J and Williams J R 1981 European Clinical Neutron Dosimetry Group (ECNEU) European protocol for neutron dosimetry for external beam therapy Br. J. Radiol. 54 882-98
8. Casal M R, Gonzlez S J, Blaumann H R, Longhino J, Calzetta Larrieu O A and Wemple C A 2004 Comparison of the performance of two NCT treatment planning systems using the therapeutic beam of the RA-6 reactor Appl. Radiat. Isot. 61 805-10
9. Durisi E, Koivunoro H, Visca L, Borla O and Zanini A 2009 Comparison of different MC techniques to evaluate BNCT dose profiles in phantom exposed to various neutron fields Radiat. Prot. Dosim. 138 213-22
10. Gonzlez S J, et al. 2004 First BNCT treatment of a skin melanoma in Argentina: dosimetric analysis and clinical outcome Appl. Radiat. Isot. 61 1101-5
11. Goorley J T, Kiger W S III and Zamenhof R G 2002 Reference dosimetry calculations for neutron capture therapy with comparison of analytical and voxel models Med. Phys. 29 145-56
12. Harling O K, Roberts K A, Moulin D J and Rogus R D 1995 Head phantoms for neutron capture therapy Med. Phys. 22 579-83
13. ICRU 1977 Neutron Dosimetry for Biology and Medicine ICRU Report No 26 (Bethesda, MD: ICRU)
14. ICRU 1989 Clinical Neutron Dosimetry: part I. Determination of Absorbed Dose in A Patient Treated by External Beams of Fast Neutrons ICRU Report No 45 (Bethesda, MD: ICRU)
15. Joensuu H, et al. 2003 Boron neutron capture therapy of brain tumors: clinical trials at the finnish facility using boronophenylalanine J. Neurooncol. 62 123-34
16. Joensuu H (principal investigator) 2005 Boronophenylalanine (BPA)-based boron neutron capture therapy (BNCT) in the treatment head and neck tumors http://clinicaltrials.gov/show/NCT00114790
17. Kankaanranta L, et al. 2007 Boron neutron capture therapy in the treatment of locally recurred head and neck cancer Int. J. Radiat. Oncol. Biol. Phys. 69 475-82
18. Koivunoro H, Kumada H, Seppälä T, Kotiluoto P, Auterinen I, Kankaanranta L and Savolainen S 2009 Comparative study of dose calculations with SERA and JCDS treatment planning systems Appl. Radiat. Isot. 67 S126-9
19. Kortesniemi M 2002 Solutions for clinical implementation of boron neutron capture therapy in Finland PhD Thesis (Report Series in Physics HU-P-D95) (Helsinki: University of Helsinki) thesis.helsinki.fi/julkaisut/mat/fysik/vk/ kortesniemi/solution.pdf
20. Kosunen A, Kortesniemi M, Ylä-Mella H, Seppälä T, Lampinen J, Serén T, Auterinen I, Järvinen H and Savolainen S 1999 Twin ionisation chambers for dose determination in phantom in an epithermal neutron beam Radiat. Prot. Dosim. 81 187-94
21. Kotiluoto P, Hiismäki P and Savolainen S 2001 Application of the new MultiTrans SP3 radiation transport code in BNCT dose planning Med. Phys. 28 1905-10
22. Kouri M, et al. 2004 Undifferentiated sinonasal carcinoma may respond to single-fraction boron neutron capture therapy Radiother. Oncol. 72 83-5
23. Kumada H, Yamamoto K, Matsumura A, Yamamoto T, Nakagawa Y, Nakai K and Kageji T 2004 Verification of the computational dosimetry system in JAERI (JCDS) for boron neutron capture therapy Phys. Med. Biol. 49 3353-65
24. Li H S, Liu Y W, Lee C Y, Lin T Y and Hsu F Y 2009 Verification of the accuracy of BNCT treatment planning system THORplan Appl. Radiat. Isot. 67 S122-5
25. Munck af Rosenschold P M, Ceberg C P, Giusti V and Andreo P 2002 Photon quality correction factors for ionization chambers in an epithermal neutron beam Phys. Med. Biol. 47 2397-409
26. Nigg D W 2003 Computational dosimetry and treatment planning considerations for neutron capture therapy J. Neurooncol. 62 75-86
27. Nigg D W, et al. 1999a Collaborative neutronic performance characterization of the FiR 1 clinical epithermal neutron beam facility for BNCT INEEL BNCT Research Program Annual Report 1998, INEEL-EXT-99-00293 ed J R Venhuizen (Idaho Falls: Martin Idaho Technologies Company) pp 13-38
28. Nigg D W, Wemple C A, Wcssol D E and Wheeler F J 1999b SERA-an advanced treatment planning system for neutron therapy and BNCT Trans. ANS 80 66-8
29. Rhoades C W A and Childs R L 1988 The DORT two-dimensional discrete ordinates transport code Nucl. Sci. Eng. 99 88-9
30. Riley K J, et al. 2008 An international dosimetry exchange for BNCT: part II. Computational dosimetry normalizations Med. Phys. 35 5419-25
31. Seppälä T 2002 FiR 1 epithermal neutron beam model and dose calculation for treatment planning in neutron capture therapy PhD Thesis (Report Series in Physics, HU-P-D103) (Helsinki: University of Helsinki) ethesis.helsinki.fi/julkaisut/mat/fysik/vk/seppala/fir1epit.pdf
32. Seppälä T, Serén T and Auterinen I 2001 Source characterization for the rtt-MC treatment planning program at FiR 1 Frontiers in Neutron Capture Therapy vol 1 ed M F Hawthorne, K Shelly and R J Wiersema (New York: Plenum Press) 219-24
33. Serén T, Auterinen I, Seppälä T and Kotiluoto P 1999 Spectrum measurements and calculations in the epithermal neutron beam at the FiR 1 BNCT facility 15th Europeon TRIGIA Conf., VTT Symp. 197 ed S Salmenhaara (Espoo: Libella) pp 167-79
34. Smith D L 1991 Probability, Statistics and Data Uncertainties in Nuclear Science and Technology (OECD Nuclear Energy Agency Nuclear Data Committee Series) (LaGrange Park, IL: American Nuclear Society)
35. Snyder W S, Fisher H L Jr, Ford M R and Warner G G 1969 Estimates for absorbed fractions for monoenergetic photon sources uniformly distributed in various organs of a heterogeneous phantom J. Nucl. Med. 47 7-52
36. Tanner V, Auterinen I, Helin J, Kosunen A and Savolainen S 1999 On line neutron beam monitoring of the Finnish BNCT facility Nucl. Instrum. Methods Phys. Res. A 422 101-5
37. Van Leemput K and Hämäläinen J A 2004 Cross-platform software framework for medical image processing Conf. on Medical Image Computing and Computer-Assisted Intervention-MICCAI 2004 (Lecture Notes in Computer Science vol 3217) pp 1091-2
38. Voorbraak W and Järvinen H 2003 Recommendations for the dosimetry of boron neutron capture therapy (BNCT) NRG Report 21425/03.55339/C (Petten: NRG)
39. Wemble C A 2007 Personal communication
40. Wojnecki C and Green S 2002 A preliminary comparative study of two treatment planning systems developed for boron neutron capture therapy: MacNCTPlan and SERA Med. Phys. 29 1710-5
41. X-5 Monte Carlo Team 2003 MCNP-a general Monte Carlo N-particle transport code, version 5 volume I: MCNP overview and theory LA-UR-03-1987 (Los Alamos, NM: Los Alamos National Laboratory) http://mcnp-green.lanl.gov/pdf/MCNP5-Manual- Volume-I-LA-UR-03-1987.pdf
42. Zamenhof R, Redmond E II, Solares G, Katz D, Riley K, Kiger S and Harling O 1996 Monte Carlo-based treatment planning for boron neutron capture therapy using custom designed models automatically generated from CT data Int. J. Radiat. Oncol. Biol. Phys. 35 383-97