Central oxytocin attenuates augmented gastric postprandial motility induced by restraint stress in rats

Neuroscience Letters

Volumn 479, Issue 3, 2010, Pages 302-306

  Bülbül, Mehmet ^a   Babygirija, Reji ^a   Ludwig, Kirk ^a   Takahashi, Toku ^a  

^a CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

CRF; Gastric emptying; HPA axis

Indexed keywords

OXYTOCIN;

ADULT ANIMAL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; IMMOBILIZATION STRESS; MALE; NONHUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; STOMACH EMPTYING; STOMACH MOTILITY; ANIMAL; DRUG EFFECTS; EXERCISE; GASTROINTESTINAL MOTILITY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MENTAL STRESS; MUSCLE CONTRACTION; PATHOPHYSIOLOGY; SMOOTH MUSCLE; SPRAGUE DAWLEY RAT; STOMACH;

ANIMALS; GASTROINTESTINAL MOTILITY; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; OXYTOCIN; POSTPRANDIAL PERIOD; RATS; RATS, SPRAGUE-DAWLEY; RESTRAINT, PHYSICAL; STOMACH; STRESS, PSYCHOLOGICAL;

EID: 77954145247     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.05.085     Document Type: Article

References (37)

1. Amico J.A., Miedlar J.A., Cai H.M., Vollmer R.R. Oxytocin knockout mice: a model for studying stress-related and ingestive behaviours. Prog. Brain. Res. 2008, 170:53-64.
2. Babygirija R., Zheng J., Ludwig K., Takahashi T. Central oxytocin is involved in restoring impaired gastric motility following chronic repeated stress in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2010, 298:R157-165.
3. Bale T.L., Davis A.M., Auger A.P., Dorsa D.M., McCarthy M.M. CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. J. Neurosci. 2001, 21:2546-2552.
4. Brown B.P., Schulze-Delrieu K., Schrier J.E., Abu-Yousef M.M. The configuration of the human gastroduodenal junction in the separate emptying of liquids and solids. Gastroenterology 1993, 105:433-440.
5. da Costa A.P., Ma X., Ingram C.D., Lightman S.L., Aguilera G. Hypothalamic and amygdaloid corticotropin-releasing hormone (CRH) and CRH receptor-1 mRNA expression in the stress-hyporesponsive late pregnant and early lactating rat. Brain Res. Mol. Brain Res. 2001, 91:119-130.
6. Flanagan L.M., Olson B.R., Sved A.F., Verbalis J.G., Stricker E.M. Gastric motility in conscious rats given oxytocin and an oxytocin antagonist centrally. Brain Res. 1992, 578:256-260.
7. Gimpl G., Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol. Rev. 2001, 81:629-683.
8. Gomez F., Manalo S., Dallman M. Androgen-sensitive changes in regulation of restraint-induced adrenocorticotropin secretion between early and late puberty in male rats. Endocrinology 2004, 145:59-70.
9. Haba T., Sarna S.K. Regulation of gastroduodenal emptying of solids by gastropyloroduodenal contractions. Am. J. Physiol. 1993, 264:G261-271.
10. Ishiguchi T., Amano T., Matsubayashi H., Tada H., Fujita M., Takahashi T. Centrally administered neuropeptide Y delays gastric emptying via Y2 receptors in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001, 281:R1522-1530.
11. Ishiguchi T., Tada H., Nakagawa K., Yamamura T., Takahashi T. Hyperglycemia impairs antro-pyloric coordination and delays gastric emptying in conscious rats. Auton. Neurosci. 2002, 95:112-120.
12. Lenz H.J., Raedler A., Greten H., Vale W.W., Rivier J.E. Stress-induced gastrointestinal secretory and motor responses in rats are mediated by endogenous corticotropin-releasing factor. Gastroenterology 1988, 95:1510-1517.
13. Li L., Kong X., Liu H., Liu C. Systemic oxytocin and vasopressin excite gastrointestinal motility through oxytocin receptor in rabbits. Neurogastroenterol. Motil. 2007, 19:839-844.
14. Liu C.Y., Chen L.B., Liu P.Y., Xie D.P., Wang P.S. Effects of progesterone on gastric emptying and intestinal transit in male rats. World J. Gastroenterol. 2002, 8:338-341.
15. Matsunaga M., Konagaya T., Nogimori T., Yoneda M., Kasugai K., Ohira H., Kaneko H. Inhibitory effect of oxytocin on accelerated colonic motility induced by water-avoidance stress in rats. Neurogastroenterol. Motil. 2009.
16. Milenov K., Kasakov L. Effect of synthetic oxytocin on the motor and bioelectrical activity of the stomach and small intestines (in vivo). Acta Physiol. Pharmacol. Bulg. 1975, 3-4:31-40.
17. Monstein H.J., Grahn N., Truedsson M., Ohlsson B. Oxytocin and oxytocin-receptor mRNA expression in the human gastrointestinal tract: a polymerase chain reaction study. Regul. Pept. 2004, 119:39-44.
18. Nakade Y., Tsuchida D., Fukuda H., Iwa M., Pappas T.N., Takahashi T. Restraint stress augments postprandial gastric contractions but impairs antropyloric coordination in conscious rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290:R616-624.
19. Nakade Y., Tsuchida D., Fukuda H., Iwa M., Pappas T.N., Takahashi T. Restraint stress delays solid gastric emptying via a central CRF and peripheral sympathetic neuron in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 288:R427-432.
20. Neumann I.D. Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis. Prog. Brain Res. 2002, 139:147-162.
21. Nishioka T., Anselmo-Franci J.A., Li P., Callahan M.F., Morris M. Stress increases oxytocin release within the hypothalamic paraventricular nucleus. Brain Res. 1998, 781:56-60.
22. Patel H., Chowdrey H.S., Lightman S.L. Lactation abolishes corticotropin-releasing factor-induced oxytocin secretion in the conscious rat. Endocrinology 1991, 128:725-727.
23. Petring O.U. The effect of oxytocin on basal and pethidine-induced delayed gastric emptying. Br. J. Clin. Pharmacol. 1989, 28:329-332.
24. Qin J., Feng M., Wang C., Ye Y., Wang P., Liu C. Oxytocin receptor expressed on the smooth muscle mediates the excitatory effect of oxytocin on gastric motility in rats. Neurogastroenterol. Motil. 2009, 21:430-438.
25. Rogers R.C., Hermann G.E. Oxytocin, oxytocin antagonist, TRH, and hypothalamic paraventricular nucleus stimulation effects on gastric motility. Peptides 1987, 8:505-513.
26. Tache Y., Bonaz B. Corticotropin-releasing factor receptors and stress-related alterations of gut motor function. J. Clin. Invest. 2007, 117:33-40.
27. Taniguchi H., Ariga H., Zheng J., Ludwig K., Mantyh C., Pappas T.N., Takahashi T. Endogenous ghrelin and 5-HT regulate interdigestive gastrointestinal contractions in conscious rats. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 295:G403-411.
28. Ueno T., Uemura K., Harris M.B., Pappas T.N., Takahashi T. Role of vagus nerve in postprandial antropyloric coordination in conscious dogs. Am. J. Physiol. Gastrointest. Liver. Physiol. 2005, 288:G487-495.
29. Vantrappen G., Janssens J., Hellemans J., Ghoos Y. The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J. Clin. Invest. 1977, 59:1158-1166.
30. Welch M.G., Tamir H., Gross K.J., Chen J., Anwar M., Gershon M.D. Expression and developmental regulation of oxytocin (OT) and oxytocin receptors (OTR) in the enteric nervous system (ENS) and intestinal epithelium. J. Comp. Neurol. 2009, 512:256-270.
31. Williams C.L., Villar R.G., Peterson J.M., Burks T.F. Stress-induced changes in intestinal transit in the rat: a model for irritable bowel syndrome. Gastroenterology 1988, 94:611-621.
32. Windle R.J., Kershaw Y.M., Shanks N., Wood S.A., Lightman S.L., Ingram C.D. Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity. J. Neurosci. 2004, 24:2974-2982.
33. Windle R.J., Shanks N., Lightman S.L., Ingram C.D. Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats. Endocrinology 1997, 138:2829-2834.
34. Wotjak C.T., Ganster J., Kohl G., Holsboer F., Landgraf R., Engelmann M. Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: new insights into the secretory capacities of peptidergic neurons. Neuroscience 1998, 85:1209-1222.
35. Wu C.L, Doong M.L., Wang P.S. Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats. Eur. J. Pharmacol. 2008, 580:407-415.
36. Wu C.L., Hung C.R., Chang F.Y., Pau K.Y., Wang P.S. Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats. Naunyn Schmiedebergs Arch. Pharmacol. 2003, 367:406-413.
37. Zheng J., Dobner A., Babygirija R., Ludwig K., Takahashi T. Effects of repeated restraint stress on gastric motility in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009, 296:R1358-R1365.