No oxygen delivery limitation in hepatic encephalopathy

Metabolic Brain Disease

Volumn 25, Issue 1, 2010, Pages 57-63

  Gjedde, Albert ^a,b,c   Keiding, Susanne ^a   Vilstrup, Hendrik ^a   Iversen, Peter ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Brain energy metabolism; Cerebral blood flow; Cerebral metabolic rate for oxygen; Hepatic encephalopathy

Indexed keywords

AMMONIA; OXYGEN; OXYGEN 15;

ADULT; AEROBIC METABOLISM; ARTERIAL BLOOD; BRAIN BLOOD FLOW; BRAIN REGION; CARBON DIOXIDE TENSION; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DIFFUSION WEIGHTED IMAGING; ENERGY METABOLISM; FEMALE; GRAY MATTER; HEPATIC ENCEPHALOPATHY; HUMAN; LIVER CIRRHOSIS; MALE; MITOCHONDRION; OXYGEN CONSUMPTION; OXYGEN TENSION; OXYGEN TRANSPORT; POSITRON EMISSION TOMOGRAPHY;

AGED; BASAL METABOLISM; BRAIN; CEREBROVASCULAR CIRCULATION; ENERGY METABOLISM; FEMALE; FIBROSIS; HEPATIC ENCEPHALOPATHY; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA; OXYGEN; OXYGEN CONSUMPTION;

EID: 77954143962     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11011-010-9179-9     Document Type: Conference Paper

References (14)

1. C Bohr 1909 Über die spezifische Tätigkeit der Lungen bei der respiratorischen Gasaufnahme und ihr Verhalten zu der durch die Alveolarwand statt findenden Gasdiffusion Skandinavisches Archiv Physiologie 22 221 280
2. JL Chen L Wei D Bereczki FJ Hans T Otsuka V Acuff G Richardson C Patlak J Fenstermacher 1994 Virtually unaltered permeability-surface area products imply little capillary recruitment in brain with hypoxia Microcirculation 1 1 35 47 10.3109/10739689409148260 1:STN:280:DyaK28zot1OisA%3D%3D 8790576 (Pubitemid 2091149)
3. A Gjedde S Marrett M Vafaee 2002 Oxidative and nonoxidative metabolism of excited neurons and astrocytes J Cereb Blood Flow Metab 22 1 1 14 10.1097/00004647-200201000-00001 1:CAS:528:DC%2BD38XlsFWmsg%3D%3D 11807388
4. A Gjedde P Johannsen GE Cold L Ostergaard 2005 Cerebral metabolic response to low blood flow: possible role of cytochrome oxidase inhibition J Cereb Blood Flow Metab 25 9 1183 1196 10.1038/sj.jcbfm.9600113 1:CAS:528:DC%2BD2MXhtVGnurjF 15815583 (Pubitemid 41710743)
5. AG Hudetz 1997 Regulation of oxygen supply in the cerebral circulation Adv Exp Med Biol 428 513 520 1:STN:280:DyaK1c7mtFSksQ%3D%3D 9500093
6. P Iversen M Sørensen LK Bak HS Waagepetersen MS Vafaee P Borghammer K Mouridsen SB Jensen H Vilstrup A Schousboe P Ott A Gjedde S Keiding 2008 Low cerebral oxygen consumption and blood flow in patients with cirrhosis and an acute episode of hepatic encephalopathy Gastroenterology 136 3 863 871 10.1053/j.gastro.2008.10.057 19041869
7. A Krogh 1919 The rate of diffusion of gases through animal tissues, with some remarks on the coefficient of invasion J Physiol 52 392 408
8. A Krogh 1919 The number and distribution of capillaries in muscles with calculation of the oxygen pressure head necessary for supplying the tissue J Physiol 52 409 415 1:CAS:528:DyaB3cXmtFer 16993405
9. A Krogh 1919 The supply of oxygen to the tissues and the regulation of the capillary circulation J Physiol 52 458 474
10. W Kuschinsky OB Paulson 1992 Capillary circulation in the brain Cerebrovasc Brain Metab Rev 4 3 261 286 1:STN:280:DyaK3s%2Fgt1WntA%3D%3D 1389958
11. S Ohta E Meyer CJ Thompson A Gjedde 1992 Oxygen consumption of the living human brain measured after a single inhalation of positron emitting oxygen J Cereb Blood Flow Metab 12 2 179 192 1:STN:280:DyaK387ptlemsw%3D%3D 1548291
12. S Ohta E Meyer H Fujita DC Reutens A Evans A Gjedde 1996 Cerebral [15O]water clearance in humans determined by PET: I. Theory and normal values J Cereb Blood Flow Metab 16 5 765 780 10.1097/00004647-199609000-00002 1:STN:280:DyaK28znvVKmuw%3D%3D 8784222
13. OB Paulson SG Hasselbalch E Rostrup GM Knudsen D Pelligrino 2010 Cerebral blood flow response to functional activation J Cereb Blood Flow Metab 30 1 2 14 10.1038/jcbfm.2009.188 19738630
14. CS Roy CS Sherrington 1890 On the regulation of the blood supply to the brain J Physiol (London) 11 1-2 85 158 1:STN:280:DC%2BD2s%2FntV2isg%3D%3D