A volumetric analysis of the brain and hippocampus of rats rendered perinatal hypothyroid

Neuroscience Letters

Volumn 479, Issue 3, 2010, Pages 240-244

  Hasegawa, Masashi ^a,b   Kida, Ikuhiro ^c   Wada, Hiromi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Hippocampus; Magnetic resonance imaging; Perinatal hypothyroidism; Thyroid hormone

Indexed keywords

ANTITHYROID AGENT; DRINKING WATER; THIAMAZOLE; LIOTHYRONINE; THYROXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DISEASE; BRAIN SIZE; BREEDING; CONTROLLED STUDY; EXPERIMENTAL RAT; FEMALE; GESTATION PERIOD; HIPPOCAMPUS; HYPOTHYROIDISM; IMAGE ANALYSIS; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CHEMICALLY INDUCED; COMPLICATION; METABOLISM; MOTHER FETUS RELATIONSHIP; ORGAN SIZE; PATHOLOGY; PREGNANCY; PREGNANCY COMPLICATION; WISTAR RAT;

ANIMALS; ANTITHYROID AGENTS; BRAIN; FEMALE; HIPPOCAMPUS; HYPOTHYROIDISM; MAGNETIC RESONANCE IMAGING; MALE; MATERNAL-FETAL RELATIONS; METHIMAZOLE; ORGAN SIZE; PREGNANCY; PREGNANCY COMPLICATIONS; RATS; RATS, WISTAR; THYROXINE; TRIIODOTHYRONINE;

EID: 77954143694     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.05.070     Document Type: Article

References (31)

1. Auso E., Lavado-Autric R., Cuevas E., Escobar del Rey F., Morreale de Escobar G., Berbel P. A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration. Endocrinology 2004, 145:4037-4044.
2. Bayer S.A., Altman J., Russo R.J., Zhang X. Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology 1993, 14:83-144.
3. Berbel P., Guadano-Ferraz A., Angulo A., Ramon Cerezo J. Role of thyroid hormones in the maturation of interhemispheric connections in rats. Behav. Brain Res. 1994, 64:9-14.
4. Berbel P., Navarro D., Ausó E., Varea E., Rodríguez A.E., Ballesta J.J., Salinas M., Flores E., Faura C.C., Morreale de Escobar G. Role of late maternal thyroid hormones in cerebral cortex development: an experimental model for human prematurity. Cereb. Cortex 2009, 212. doi:10.1093.bhp212.
5. Bernal J., Nunez J. Thyroid hormones and brain development. Eur. J. Endocrinol. 1995, 133:390-398.
6. Cooper D.S. Antithyroid drug. N. Engl. J. Med. 2005, 352:905-917.
7. Courchesne E., Karns C.M., Davis H.R., Ziccardi R., Carper R.A., Tigue Z.D., Chisum H.J., Moses P., Pierce K., Lord C.A., Lincoln J. Unusual brain growth patterns in early life in patients with autistic disorder. Neurology 2001, 57:245-254.
8. Farahvar A., Meisami E. Novel two-dimensional morphometric maps and quantitative analysis reveal marked growth and structural recovery of the rat hippocampal regions from early hypothyroid retardation. Exp. Neurol. 2007, 204:541-555.
9. Farahvar A., Darwish N.H., Sladek S., Meisami E. Marked recovery of functional metabolic activity and laminar volumes in the rat hippocampus and dentate gyrus following postnatal hypothyroid growth retardation: a quantitative cytochrome oxidase study. Exp. Neurol. 2007, 204:556-568.
10. Gilbert M.E. Alterations in synaptic transmission and plasticity in area CA1 of adult hippocampus following developmental hypothyroidism. Dev. Brain Res. 2004, 148:11-18.
11. Gilbert M.E., Paczkowski C., Propylthiouracil (PTU)-induced hypothyroidism in the developing rat impairs synaptic transmission and plasticity in the dentate gyrus of the adult hippocampus. Dev. Brain Res. 2003, 145:19-29.
12. Gilbert M.E., Sui L. Dose-dependent reductions in spatial learning and synaptic function in the dentate gyrus of adult rats following developmental thyroid hormone insufficiency. Brain Res. 2006, 1069:10-22.
13. Howdeshell K.L. A model of the development of the brain as a construct of the thyroid system. Environ. Health Perspect. 2002, 110:337-348.
14. Kim J.H.Y., Juraska J.M. Sex differences in the development of axon number in the splenium of the rat corpus callosum from postnatal day 15 through 60. Dev. Brain Res. 1997, 102:77-85.
15. Koibuchi N., Chin W.W. Thyroid hormone action and brain development. Trends Endocrinol. Metab. 2000, 4:123-128.
16. Lavado-Autric R., Ausó E., García-Velasco J.V., Arufe M., Escobar del Rey F., Berbel P., Morreale de Escobar G. Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. J. Clin. Invest. 2003, 111:1073-1082.
17. Madeira M.D., Cadete-Leite A., Andrade J.P., Paula-Barbosa M.M. Effects of hypothyroidism upon the granular layer of the dentate gyrus in male and female adult rats: a morphometric study. J. Comp. Neurol. 1991, 314:171-186.
18. Madeira M.D., Sousa N., Lima-Andrade M.T., Calheiros F., Cadete-Leite A., Paula-Barbosa M.M. Selective vulnerability of the hippocampal pyramidal neurons to hypothyroidism in male and female rats. J. Comp. Neurol. 1992, 322:501-518.
19. Madeira M.D., Paula-Barbosa M.M. Reorganization of mossy fiber synapses in male and female hypothyroid rats: a stereological study. J. Comp. Neurol. 1993, 337:334-352.
20. Marchant B., Brownlie B.E., McKay-Hart D., Horton P.W., Alexander W.D. The placental transfer of propylthiouracil, methimazole and carbimazole. J. Clin. Endocrinol. Metab. 1977, 45:1187-1193.
21. Martinez-Galan J.R, Pedraza P., Santacana M., Escobar del Rey F., Morreale de Escobar G., Ruiz Marcos A. Early effects of iodine deficiency on radial glial cells of the hippocampus of the rat fetus: a model of neurological cretinism. J. Clin. Invest. 1997, 99:2701-2709.
22. Martinez-Galan J.R., Escobar Del Rey F., Morreale de Escobar G., Santacana M., Ruiz-Marcos A. Hypothyroidism alters the development of radial glial cells in the term fetal and postnatal neocortex of the rat. Dev. Brain Res. 2004, 153:109-114.
23. Opazo M.C., Gianini A., Pancetti F., Azkcona G., Alarcon L., Lizana R., Noches V., Gonzalez P.A., Marassi M.P., Mora S., Rosenthal D., Eugenin E., Naranjo D., Bueno S.M., Kalergis A.M., Riedel C.A. Maternal hypothyroxinemia impairs spatial learning and synaptic nature and function in the offspring. Endocrinology 2008, 149:5097-5106.
24. Oppenheimer J.H., Schwartz H.L. Molecular basis of thyroid hormone-dependent brain development. Endocr. Rev. 1997, 18:462-475.
25. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2007, Academic Press, San Diego. sixth edn.
26. Porterfield S.P., Hendrich C.E. The role of thyroid hormones in prenatal and neonatal neurological development-current perspectives. Endocr. Rev. 1993, 14:94-106.
27. Rakic P. Guidance of neurons migrating to the fetal monkey neocortex. Brain Res. 1971, 33:471-476.
28. Rami A., Rabie A., Patel A.J. Thyroid hormone and development of the rat hippocampus: cell acquisition in the dentate gyrus. Neuroscience 1986, 19:1207-1216.
29. Rami A., Patel A.J., Rabié A. Thyroid hormone and development of the rat hippocampus: morphological alterations in granule and pyramidal cells. Neuroscience 1986, 19:1217-1226.
30. Thompson C.C., Potter G.B. Thyroid hormone action in neural development. Cereb. Cortex 2000, 10:939-945.
31. Wolf O.T., Dyakin V., Vadasz C., de Leon M.J., McEwen B.S., Bulloch K. Volumetric measurement of the hippocampus, the anterior cingulate cortex, and the retrosplenial granular cortex of the rat using structural MRI. Brain Res. Brain Res. Protoc. 2002, 10:41-46.