Synthesis and biological testing of N-aminoimidazole-based p38α MAP kinase inhibitors

ChemMedChem

Volumn 5, Issue 7, 2010, Pages 1134-1142

  Bracht, Claudia ^a   Hauser, Dominik R J ^a,b   Schattel, Verena ^a   Albrecht, Wolfgang ^b   Laufer, Stefan A ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b C a i r Biosciences GmbH   (Germany)

Author keywords

Cytokines; Inhibitors; p38 MAP kinase; Pyridinylimidazoles

Indexed keywords

AMINE; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE;

ACYLATION; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROPHOBICITY; INFLAMMATION; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING SITES; COMPUTER SIMULATION; IMIDAZOLES; MITOGEN-ACTIVATED PROTEIN KINASE 14; PROTEIN KINASE INHIBITORS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77954126404     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000114     Document Type: Article

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