The binding affinity of carcinogenic N-nitrosodimethylamine and N-nitrosomethylaniline to cytochromes P450 2B4, 2E1 and 3A6 does not dictate the rate of their enzymatic N-demethylation

General Physiology and Biophysics

Volumn 29, Issue 2, 2010, Pages 175-185

  Šulc, Miroslav ^a,b   Hodek, Petr ^a   Stiborová, Marie ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF MICROBIOLOGY   (Czech Republic)

Author keywords

CYP2B4; CYP2E1; CYP3A6; Cytochrome P450; N nitrosamines

Indexed keywords

CARCINOGEN; CYTOCHROME P450; CYTOCHROME P450 2B4; CYTOCHROME P450 2E1; CYTOCHROME P450 3A6; DIMETHYLNITROSAMINE; N METHYL N NITROSOANILINE; UNCLASSIFIED DRUG; CYTOCHROME P-450 CYP2B4 (RABBIT); CYTOCHROME P-450 CYP3A6 (RABBIT); LIPOSOME; N-METHYL-N-NITROSOANILINE; NITROSAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNSPECIFIC MONOOXYGENASE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHEMICAL CARCINOGENESIS; CHEMICAL STRUCTURE; DEMETHYLATION; DISSOCIATION CONSTANT; ENZYME ACTIVITY; KIDNEY MICROSOME; LIVER MICROSOME; METABOLISM; NONHUMAN; OXIDATION; RABBIT; TOXICOKINETICS; ANIMAL; IN VITRO STUDY; KINETICS; OXIDATION REDUCTION REACTION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CARCINOGENS; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; DIMETHYLNITROSAMINE; IN VITRO TECHNIQUES; KINETICS; LIPOSOMES; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; NITROSAMINES; OXIDATION-REDUCTION; RABBITS;

EID: 77954123833     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: 10.4149/gpb_2010_02_175     Document Type: Article

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