Aminoglycoside pharmacokinetic parameters in neurocritical care patients undergoing induced hypothermia

Pharmacotherapy

Volumn 30, Issue 7, 2010, Pages 654-660

  Mercer, Jessica M ^a   Neyens, Ron R ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Aminoglycoside; Antibiotic; Critical care; Hypothermia; Neuroprotection; Pharmacokinetics

Indexed keywords

AMINOGLYCOSIDE; CISATRACURIUM; MEROPENEM; NORADRENALIN; PENTOBARBITAL; PHENYLEPHRINE; PHENYTOIN; TOBRAMYCIN; ANTIINFECTIVE AGENT; CREATININE;

ADULT; ANAMNESIS; ARTICLE; CASE REPORT; CLINICAL FEATURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; HUMAN; INDUCED HYPOTHERMIA; INTENSIVE CARE; INTRACRANIAL HYPERTENSION; MALE; VENTILATOR ASSOCIATED PNEUMONIA; BLOOD; CLINICAL TRIAL (TOPIC); FATALITY; HALF LIFE TIME; HYPERTENSION; INTENSIVE CARE UNIT; MIDDLE AGED; PATIENT CARE; PROCEDURES; TREATMENT OUTCOME; YOUNG ADULT;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; CLINICAL TRIALS AS TOPIC; CREATININE; FATAL OUTCOME; HALF-LIFE; HUMANS; HYPERTENSION; HYPOTHERMIA, INDUCED; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PATIENT CARE; TOBRAMYCIN; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77954107129     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.30.7.654     Document Type: Article

References (22)

1. Polderman KH. Induced hypothermia and fever control for prevention and treatment of neurological injuries. Lancet 2008;371:1955-69.
2. Sahuquillo J, Vilalta A. Cooling the injured brain: how does moderate hypothermia influence the pathophysiology of traumatic brain injury. Curr Pharm Des 2007;13:2310-22.
3. Bernard SA, Buist M. Induced hypothermia in critical care medicine: a review. Crit Care Med 2003;31:2041-51. (Pubitemid 36900763)
4. Tortorici MA, Kochanek PM, Poloyac SM. Effects of hypothermia on drug disposition, metabolism, and response: a focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system. Crit Care Med 2007;35:2196-204.
5. Arpino PA, Greer DM. Practical pharmacologic aspects of therapeutic hypothermia after cardiac arrest. Pharmacotherapy 2008;28:102-11.
6. Zeiner A, Sunder-Plassmann G, Sterz F, et al. The effect of mild therapeutic hypothermia on renal function after cardiopulmonary resuscitation in men. Resuscitation 2004;60:253-61.
7. Brain Trauma Foundation, American Association of Neurological Surgeons, Congress of Neurological Surgeons. Guidelines for the management of severe traumatic brain injury. J Neurotrauma 2007;24(suppl 1):S1-106.
8. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976:16:31-41.
9. Sawyer WT, Canaday BR, Poe TE, et al. Variables affecting creatinine clearance prediction. Am J Health Syst Pharm 1983;40:2175-80.
10. Sawchuk RJ, Zaske DE. Pharmacokinetics of dosing regimens which utilize multiple intravenous infusions: gentamicin in burn patients. J Pharmacokinet Biopharm 1976;4:183-95.
11. Tang GJ, Tang JJ, Lin BS, Kong CW, Lee TY. Factors affecting gentamicin pharmacokinetics in septic patients. Acta Anaesthesiol Scand 1999:43;726-30.
12. Wolfe TA, Dasta J. Once-daily aminoglycoside dosing in critically ill patients [comment]. Ann Pharmacother 1998;32:1109-10.
13. Barletta JF, Johnson SB, Nix DE, Nix LC, Erstad BL. Population pharmacokinetics of aminoglycosides in critically ill trauma patients on once-daily regimens. J Trauma 2000;49:869-72.
14. Brusco L, Talbert S, Wedderburn RV. Once-daily aminoglycoside dosing protocol results in inadequate gentamicin levels in surgical intensive care unit patients with normal renal function [abstract]. Crit Care Med 1999;27:A138.
15. Koren G, Barker C, Bohn D, Kent G, Biggar D. Influence of hypothermia on the pharmacokinetics of gentamicin and theophylline in piglets. Crit Care Med 1985;13:844-7. (Pubitemid 15250142)
16. Satas S, Hoem NO, Melby K, et al. Influence of mild hypothermia after hypoxia-ischemia on the pharmacokinetics of gentamicin in newborn pigs. Biol Neonate 2000;77:50-7.
17. Metz C, Holzschuh M, Bein T, et al. Moderate hypothermia in patients with severe head injury: cerebral and extracerebral effects. J Neurosurg 1996;85:533-41. (Pubitemid 26315182)
18. Pérez-Bárcena J, Llompart-Pou JA, Homar J, et al. Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial [online exclusive article]. Crit Care 2008;12:R112. Available from http://ccforum.com/content/12/4/R112.
19. Dowell JA, Korth-Bradley J, Milisci M, Tantillo K, Amorusi P, Tse S. Evaluating possible pharmacokinetic interactions between tobramycin, piperacillin, and a combination of piperacillin and tazobactam in patients with various degrees of renal impairment. J Clin Pharmacol 2001;41:979-86.
20. Hoste EA, Damen J, Vanholder RC, et al. Assessment of renal function in recently admitted critically ill patients with normal serum creatinine. Nephrol Dial Transplant 2005;20:747-53.
21. Demczar DJ, Nafziger AN, Bertino JS Jr. Pharmacokinetics of gentamicin at traditional versus high doses: implications for once-daily aminoglycoside dosing. Antimicrob Agents Chemother 1997;41:1115-19.
22. McNamara DR, Nafziger AN, Menhinick AM, Bertino JS Jr. A dose-ranging study of gentamicin pharmacokinetics: implications for extended interval aminoglycoside therapy. J Clin Pharmacol 2001;41:374-7.