Chronic treatment with a selective inhibitor of casein kinase I δ/ε yields cumulative phase delays in circadian rhythms

Psychopharmacology

Volumn 210, Issue 4, 2010, Pages 569-576

  Sprouse, Jeffrey ^a,c   Reynolds, Linda ^a   Kleiman, Robin ^a   Tate, Barbara ^a   Swanson, Terri A ^a   Pickard, Gary E ^b  

^a PFIZER INC   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^c LUNDBECK RESEARCH USA   (United States)

Author keywords

Biological clock; Circadian rhythm; Phosphorylation; Suprachiasmatic nucleus

Indexed keywords

4 [3 CYCLOHEXYL 5 (4 FLUOROPHENYL) 3H IMIDAZOL 4 YL]PYRIMIDIN 2 YLAMINE; CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; PF 670462; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG HALF LIFE; DRUG MEGADOSE; FEMALE; LOW DRUG DOSE; MOTOR ACTIVITY; NONHUMAN; OSCILLATION; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; BIOLOGICAL CLOCKS; CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; CIRCADIAN RHYTHM; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MOTOR ACTIVITY; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 77954099912     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-1860-5     Document Type: Article

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