Preserved metabolic coupling and cerebrovascular reactivity during mild hypothermia after cardiac arrest

Critical Care Medicine

Volumn 38, Issue 7, 2010, Pages 1542-1547

  Bisschops, Laurens L A ^a   Hoedemaekers, Cornelia W E ^a   Simons, Koen S ^a   Van Der Hoeven, Johannes G ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

cardiac arrest; cerebral blood flow; cerebral metabolic coupling; cerebrovascular reactivity; mild hypothermia

Indexed keywords

ADRENALIN; DOBUTAMINE; NORADRENALIN;

ADULT; AGED; ARTERIAL BLOOD; ARTICLE; BLOOD CARBON DIOXIDE TENSION; BRAIN BLOOD FLOW; CLINICAL ARTICLE; COMATOSE PATIENT; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; FEMALE; FLOW RATE; HEART ARREST; HUMAN; INDUCED HYPOTHERMIA; INTENSIVE CARE UNIT; LUNG MINUTE VOLUME; MALE; MIDDLE CEREBRAL ARTERY; PRIORITY JOURNAL;

EID: 77954071875     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181e2cc1e     Document Type: Article

References (25)

1. Lassen NA: Cerebral blood flow and oxygen consumption in man. Physiol Rev 1959; 39: 183-238
2. 2 and cerebral hemo-dynamics. Am J Physiol 1964; 206:25-35
3. Roy CS, Sherrington CS: On the regulation of the blood-supply of the brain. J Physiol 1890; 11:85-158
4. Buunk G, van der Hoeven JG, Frolich M, et al: Cerebral vasoconstriction in comatose patients resuscitated from a cardiac arrest? Intensive Care Med 1996; 22:1191-1196
5. Lemiale V, Huet O, Vigue B, et al: Changes in cerebral blood flow and oxygen extraction during post-resuscitation syndrome. Resuscitation 2008; 76:17-24
6. Bisschops L, Hoedemaekers C, van der Hoeven J: Changes in cerebral blood flow and oxygen extraction during the post-resuscitation syndrome. Resuscitation 2008; 77:415-416
7. Bernard SA, Gray TW, Buist MD, et al: Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002; 346:557-563
8. Laffey JG, Kavanagh BP: Hypocapnia. N Engl J Med 2002; 347:43-53
9. Yenari M, Kitagawa K, Lyden P, et al: Metabolic downregulation: A key to successful neuropro-tection? Stroke 2008; 39:2910-2917
10. Lavinio A, Timofeev I, Nortje J, et al: Cere-brovascular reactivity during hypothermia and rewarming. Br J Anaesth 2007; 99: 237-244
11. Nolan JP, Morley PT, Van den Hoek TL, et al: Therapeutic hypothermia after cardiac arrest: An advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation. Circulation 2003; 108:118-121
12. Goetting MG, Preston G: Jugular bulb cath-eterization: Experience with 123 patients. Crit Care Med 1990; 18:1220-1223
13. Van den Berghe G, Wouters P, Weekers F, et al: Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345: 1359-1367
14. Van den Berghe G, Wilmer A, Hermans G, et al: Intensive insulin therapy in the medical ICU. N Engl J Med 2006; 354:449-461
15. Aaslid R, Markwalder TM, Nornes H: Nonin-vasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 1982; 57:769-774
16. Sorteberg W, Langmoen IA, Lindegaard KF, et al: Side-to-side differences and day-to-day variations of transcranial Doppler parameters in normal subjects. J Ultrasound Med 1990; 9:403-409
17. Bishop CC, Powell S, Rutt D, et al: Transcra-nial Doppler measurement of middle cerebral artery blood flow velocity: A validation study. Stroke 1986; 17:913-915
18. Newell DW, Aaslid R, Lam A, et al: Comparison of flow and velocity during dynamic autoregulation testing in humans. Stroke 1994; 25:793-797 (Pubitemid 24111325)
19. Larsen FS, Olsen KS, Hansen BA, et al: Transcranial Doppler is valid for determination of the lower limit of cerebral blood flow autoregulation. Stroke 1994; 25:1985-1988
20. Erecinska M, Thoresen M, Silver IA: Effects of hypothermia on energy metabolism in mammalian central nervous system. J Cereb Blood Flow Metab 2003; 23:513-530
21. Nordmark J, Rubertsson S, Mortberg E, et al: Intracerebral monitoring in comatose patients treated with hypothermia after a cardiac arrest. Acta Anaesthesiol Scand 2009; 53:289-298
22. Hetzel A, Braune S, Guschlbauer B, et al: CO2 reactivity testing without blood pressure monitoring? Stroke 1999; 30:398-401
23. Klingelhofer J, Sander D: Doppler CO2 test as an indicator of cerebral vasoreactivity and prognosis in severe intracranial hemorrhages. Stroke 1992; 23:962-966
24. Lee JH, Kelly DF, Oertel M, et al: Carbon dioxide reactivity, pressure autoregulation, and metabolic suppression reactivity after head injury: A transcranial Doppler study. J Neurosurg 2001; 95:222-232
25. Falkenbach P, Kämäräinen A, Mäkelä A, et al: Incidence of iatrogenic dyscarbia during mild therapeutic hypothermia after successful resuscitation from out-of-hospital cardiac arrest. Resuscitation 2009; 80:990-993