Tissue distribution, pharmacokinetics and stability studies of zidovudine delivered by niosomes and proniosomes

Journal of Biomedical Nanotechnology

Volumn 6, Issue 1, 2010, Pages 43-51

  Ruckmani, Kandasamy ^a   Sankar, Veintramuthu ^b   Sivakumar, Manickam ^c  

^a ANNA UNIVERSITY   (India)

^b PSG COLLEGE OF PHARMACY   (India)

^c UNIVERSITY OF NOTTINGHAM MALAYSIA CAMPUS   (Malaysia)

Author keywords

Niosomes; Pharmacokinetic evaluation; Proniosomes; Stability studies; Tissue distribution studies; Zidovudine

Indexed keywords

A-STABILITY; ANTI-HIV; DICETYLPHOSPHATE; DRUG LEAKAGE; INTRAVENOUS ADMINISTRATION; MEAN RESIDENCE TIME; NEGATIVE CHARGE; NIOSOMES; PHARMACOKINETIC EVALUATION; PHARMACOKINETIC STUDIES; ROOM TEMPERATURE; STABILITY STUDY; TARGETED DELIVERY; TISSUE DISTRIBUTIONS; TWEEN 80;

DRUG PRODUCTS; LIVER; STABILITY; SURFACE ACTIVE AGENTS; TISSUE;

PHARMACOKINETICS;

BETA CYCLODEXTRIN; DICETYL PHOSPHATE; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; NIOSOME; POLYSORBATE 80; PRONIOSOME; SURFACTANT; UNCLASSIFIED DRUG; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; LIPOSOME; POLYSORBATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CIRCULATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; ENCAPSULATION; HEART; KIDNEY; LIVER; LUNG; MOUSE; NONHUMAN; ROOM TEMPERATURE; SPLEEN; TISSUE DISTRIBUTION; ANALYSIS OF VARIANCE; ANIMAL; AREA UNDER THE CURVE; CHEMISTRY; DRUG STABILITY; HALF LIFE TIME; MALE; METABOLISM; METHODOLOGY; PARTICLE SIZE; RABBIT;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-HIV AGENTS; AREA UNDER CURVE; DRUG DELIVERY SYSTEMS; DRUG STABILITY; HALF-LIFE; LIPOSOMES; LIVER; MALE; MICE; PARTICLE SIZE; POLYSORBATES; RABBITS; SPLEEN; TISSUE DISTRIBUTION; ZIDOVUDINE;

EID: 77954059841     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2010.1101     Document Type: Article

References (36)

1. M. Poznansky and R. L. Juliano, Biological approaches to the controlled delivery of drugs: A critical review. Pharmacol. Rev. 36, 277 (1984).
2. S. M. Moghimi, I. S. Muir, Lilium, S. S. Davis, and V. Kolbachofen, Coating particles with a block co-polymer (polamer-908) suppresses opsonization but permits the actinity. Biochim. Biophys. Acta 1179, 157 (1993).
3. M. N. Azmin, A. T. Florence, R. M. H. Janivila, J. F Stewart, G. Vanleberge, and J. S. Whittaker, The effect of nonionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. J. Pharm. Pharmacol. 37, 237 (1985).
4. A. Rogerson, J. Cummings, N. Willmottand, and A. T. Florence, Adriamycin-loaded niosomes: Drug entrapment, stability and release. J. Pharm. Pharmcol. 401, 37 (1988).
5. A. J. Baillie, G. H. Coombs, G. D. Dillan, and J. Laurio, Non-ionic surfactant vesicles: Niosomes as a delivery system for the anti-leishmaniacal drug, sodium stibogluconate. J. Pharm. Pharmacol. 38, 502 (1986).
6. A. I. Blazekwelsh and D. G. Rhodes, Maltodextrin-based proniosomes. AAPS PharmSci. 3, 1 (2001).
7. R. Klecker, J. Collins, R. Yarchoan, R. Thomas, J. F. Jenkins, S. Broder, and C. E. Myers, Plasma and cerebrospinal fluid pharmacokinetics of 3′-azido-3′-deoxythymidine: A novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases. Clin. Pharmacol. Then 41, 407 (1987).
8. F. M. Balis, P. A. Pizzo, J. Eddy, C. Wilfert, R. McKinney, G. Scott, R. F. Murphy, P. F. Jarosinki, J. Fallon, and D. G. Poplack, The pharmacokinetics of azidothymidine administered intravenously and orally in children with human immunodeficiency virus infection. Pediatr. 114, 880 (1989).
9. F. M. Balis, P. A. Pizzo, J. Eddy, R. F. Murphy, P. F. Jarosinki, J. Fallon, S. Broder, and D. G. Poplack, The pharmacokinetics of zidovudine administered by continuous infusion in children. Ann. Intern. Med. 110, 279 (1989).
10. D. D. Richman, M. A. Fischl, M. H. Grieco, M. S. Gottliab, P. A. Volberding, O. L. Laskin, J. M. Leedom, J. E. Groopman, D. Mildvan, M. S. Hirsch, G. G. Jackson, D. T. Durack, and S. N. Lehrman, The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. N. Engl. J. Med. 317, 192 (1987).
11. J. D. Lutton, A. Mathew, R. D. Levere, and N. G. Abraham, Role of heme metabolism in AZT-induced bone marrow toxicity. Am. J. Hematol. 35, 1 (1990).
12. P. R. Chow and A. W. Hamburger, In vivo evaluation of the anemia induced by azidothymidine(AZT) in a murine model of AID. Eur. J. Hematol. 47, 97 (1991).
13. H. M. Patel, N. S. Tuzel, and B. E. Ryman, Inhibitory effect of cholesterol on the uptake of liposomes by liver and spleen. Biochim. Biophys. Acta. 761, 142 (1983).
14. J. Dave and H. M. Patel, Differentiation in hepatic and splenic phagocytic activity during reticuloendothelial blockade with cholesterol-free and cholesterol-rich liposomes. Biochim. Biophys. Acta. 888, 184 (1986).
15. H. M. Patel, Serum opsonins and liposomes: Their interaction and opsonophagocytosis. Crit. Rev. Ther. Drug Carrier Syst. 9, 39 (1992).
16. S. C. Semple, A. Chonn, P. R. Cullis, Influence of cholesterol on the association of plasma proteins with liposomes. Biochemistry 35, 2521 (1996).
17. K. Ruckmani and V. Sankar, Formulation and optimization of zidovudine niosomes. Drug Dev. Ind. Pharm. (Communicated).
18. S. Jain, B. Umamaheswari, D. Bhadra, and N. K. Jain, Ethosomes: A novel carrier for enhanced transdermal delivery of an anti-HIV agent. Indian J. Pharm. Sci. 66, 72 (2004).
19. Y. Perrie, J. E. Barralet, S. McNeil, and A. Vangala, Surfactant vesicle-mediated delivery of DNA vaccines via the subcutaneous route. Int J. Pharm. 284, 31 (2004).
20. M. N. Ghosh, Fundamentals of Experimental Pharmacology, Hilton and Company, Kolkota (2005).
21. OECD guideline 423. Organisation for Economic Co-operation and Development, Accessed 19 November 2008
22. A. Kuksal, A. K. Tiwary, N. K. Jain, and S. Jain, Formulation and in vitro, in vivo evaluation of extended release matrix tablets of zidovudine: Influence of combination of hydrophilic and hydrophobic matrix formers. AAPS PharmSciTech. 7, 1 (2007).
23. D. P. Callender, N. Jayaprakash, A. Bell, V. Petraitis, R. Petraitiene, M. Candelario, R. Schaufele, J. M. Dunn, S. Sei, T. J. Walsh, and F. M. Balis, Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits. Antimicrob. Agents Ch. 43, 972 (1999).
24. L. V. Wenli, G. Jianxin, L. I. Jin, W. Xueliang, L. Jianying, and P. Qineng, Preparation and pharmacokinetics in rabbits of Breviscapine unilamellar vesicles. Drug Dev. Ind. Pharm. 32, 309 (2006).
25. S. Singh, Pharmaceutical Product Development, edited by N. K. Jain, CBS Publishers and Distributors, India (2006), Vol. 277, pp. 272-293.
26. R. Agarwal, O. P. Katare, and S. P. Vyas, Preparation and in vitro evaluation of liposomal/niosomal delivery systems for antipsoriatic drug dithranol. Int. J. Pharm. 228, 43 (2001).
27. A. Shahiwala and A. Misra, Studies in topical application of niosomally-entrapped nimesulide. J. Pharm. Pharmaceut. Sci. 5, 220 (2002).
28. M. Manconi, D. Valenti, C. Sinico, F. Lai, G. Loy, and A. M. Fadda, Niosomes as carriers for tretinoin. I. Preparation and properties. Int. J. Pharm. 234, 237 (2002).
29. T. Lian and R. J. Y. Ho, Trends and developments in liposome drug delivery systems. J. Pharm. Sci. 90, 667 (2001).
30. F. H. Roerdirk, J. Regts, T. Handel, S. M. Sullivan, J. D. Baldeschwieler, and G. L. Scherphof, Effect of cholesterol on the uptake and intracellular degradation of liposomes by liver and spleen: A combined biochemical and gamma-ray perturbed angular correlation study. Biochim. Biophys. Acta. 980, 234 (1989).
31. J. M. T. Koppele and R. G. Thurman, Phagocytosis of Kuppfer cells predominates in pericentral regions of the liver lobule. Am. J. Physiol. 22, 814 (1990).
32. J. Senior, J. C. W. Crawley and G. Gregoriades, Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection, Biochim. Biophys. Acta. 839, 1 (1985).
33. A. Chom, S. C. Semple, and P. R. Cullis, Association of blood proteins with large unilamellar liposomes: In vivo relation to circulation lifetimes. J. Biol. Chem. 167, 18759 (1992).
34. R. L. Juliano and G. Lin, Liposome and Immunology, edited by B. H. Tom, Elsevier, New York (1980), pp 49
35. A. Chonn, P. R. Cullis, D. V. Devine, The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes. J. Immunol. 146, 4234 (1991).
36. F. J. You, H. C. Tzong, C. W. Ta, and W. Y. Yue, Effect of liposomes and niosomes on skin permeation of enoxacins. Int. J. Pharm. 219, 61 (2001).