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Moments of allele frequency distributions can also be expressed in terms of probabilities of identity by descent (IBD). For example, the second and third moments are proportional to the probabilities that two or three (respectively) randomly sampled alleles within a group are IBD (23).
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Moments of allele frequency distributions can also be expressed in terms of probabilities of identity by descent (IBD). For example, the second and third moments are proportional to the probabilities that two or three (respectively) randomly sampled alleles within a group are IBD (23).
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note
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We thank G. Velicer for funding and laboratory support through NIH grant GM07690 and S. Alizon, W. Castle, D. Queller, and W. Ratcliff for discussion and comments on the manuscript. J.D.V.D. was supported by NIH grant R01GM084238 to M.J. Wade. P.C.Z. was supported by the Genetics, Cellular and Molecular Sciences Training Grant (T32GM007757). All authors conceived the project, discussed the results, and commented on the paper, j.s. and D.V.D. designed the theoretical approach, j.s. did the math, designed and performed the experiments, and wrote the paper, j.s. and P.C.Z. analyzed the data.
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