Expression and significance of FXYD-3 protein in gastric adenocarcinoma

Disease Markers

Volumn 28, Issue 2, 2010, Pages 63-69

  Zhu, Zhen Long ^a   Zhao, Zeng Ren ^a   Zhang, Yu ^a   Yang, Yan Hong ^a   Wang, Zheng Min ^a   Cui, Dong Sheng ^a   Wang, Ming Wei ^a   Kleeff, Jörg ^b   Kayed, Hany ^c   Yan, Bao Yong ^a   Sun, Xiao Feng ^d  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d LINKÖPING UNIVERSITY   (Sweden)

Author keywords

FXYD 3; gastric cancer; immunohistochemistry

Indexed keywords

FXYD 3 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); FXYD3 PROTEIN, HUMAN; TUMOR PROTEIN;

ADULT; ARTICLE; CANCER CELL; CANCER INVASION; CANCER PATIENT; CANCER SURGERY; CARCINOGENESIS; CONTROLLED STUDY; CYTOPLASM; DEMOGRAPHY; DISEASE ASSOCIATION; EPITHELIUM CELL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH ADENOCARCINOMA; STOMACH EPITHELIUM; TUMOR VOLUME; UPREGULATION; ADENOCARCINOMA; LYMPH NODE METASTASIS; METABOLISM; METASTASIS; MIDDLE AGED; PATHOLOGY; STOMACH MUCOSA; STOMACH TUMOR;

ADENOCARCINOMA; FEMALE; GASTRIC MUCOSA; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; SODIUM-POTASSIUM-EXCHANGING ATPASE; STOMACH NEOPLASMS; UP-REGULATION;

EID: 77954037634     PISSN: 02780240     EISSN: None     Source Type: Journal    
DOI: 10.3233/DMA-2010-0669     Document Type: Article

References (22)

1. K. Geering, FXYD3 proteins: new regulators of Na -KATPase, Am J Physiol Renal Physiol 290 (2006), 241-250.
2. K.J. Sweadner and E. Rael, The FXYD gene family of small ion transport regulators or channels: CDNA sequence, protein signature sequence, and xpression, Genomics 68 (2000), 41-56.
3. C.J. Palmer, B.T. Scott and L.R. Jones, Purification and complete sequence determination of the major plasma membrane substrate for cAMP-dependent protein kinase and protein kinaseCin myocardium, J Biol Chem 266 (1991), 11126-11130.
4. R.W. Mercer, D. Biemesderfer, D.P. Bliss, J.H. Collins and B. Forbush, Molecular cloning and immunological characterization of the polypeptide, a small protein associated with the Na, K-ATPase, J Cell Biol 121 (1993), 579-586.
5. B.W. Morrison, J.R. Moorman, G.C. Kowdley, Y.M. Kobayashi, L.R. Jones and P. Leder, Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes, J Biol Chem 270 (1995), 2176-2182.
6. B. Attali, H. Latter, N. Rachamim and H. Garty, A corticosteroid-induced gene expressing an "IsK-like" K+ channel activity in Xenopus oocytes, Proc Natl Acad Sci USA 92 (1995), 6092-6096.
7. X. Fu and M. Kamps, E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts, Mol Cell Biol 17 (1997), 1503-1512.
8. F. Yamaguchi, K. Yamaguchi, Y. Tai, K. Sugimoto and M. Tokuda, Molecular cloning and characterization of a novel phospholemman-like protein from rat hippocampus, Brain Res Mol Brain Res 86 (2001), 189-192.
9. P. B́eguin, G. Crambert, F. Monnet-Tschudi, M. Uldry, J.-D. Horisberger, H. Garty and K. Geering, FXYD7 is a brainspecific regulator of Na, K-ATPase 1- isozymes, EMBO J 21 (2002), 3264-3273.
10. B.W. Morrison and P. Leder, Neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-initiated tumors, Oncogene 9 (1994), 3417-3426.
11. M. Grzmil, S. Voigt, P. Thelen, B. Hemmerlein, K. Helmke and P. Burfeind, Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells, Int J Oncol 24 (2004), 97-105.
12. H. Kayed, J. Kleeff, A. Kolb, K. Ketterer, S. Keleg, K. Felix, T. Giese, R. Penzel, H. Zentgraf, M.W. Büchler, M. Korc and H. Friess, FXYD3 is overexpressed in pancreatic ductal adenocarrinoma and influences pancreatic cancer cell growth, Int J Cancer 118 (2006), 43-54.
13. G. Crambert, C. Li, D. Claeys and K. Geering, FXYD3(Mat-8), a new regulator of Na, K-ATPase, Mol Biol Cell 16 (2005), 2363-2371.
14. S. Bibert, S. Rov, D. Schaer, E. Felley-Bosco and K. Geering, Structural and functional properties of two human FXYD3(Mat-8) isoforms, J Biol Chem 281 (2006), 39142-39151.
15. J. Arimochi, A. Kobayashi and M. Maeda, Stable expression and visualization of Mat-8 (FXYD-3) tagged with a fluorescent protein in Chinese hamster ovary (CHO)-K1 cells, Biotechnol lett 27 (2005), 1017-1024.
16. J. Arimochi, A. Ohashi-Kobayashi and M. Maeda, Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells, Biol Pharm Bull 30 (2007), 648-654.
17. C.A. Iacobuzio-Donahue, A. Maitra, M. Olsen, A.W. Lowe, N.T. van Heek, C. Rosty, K. Walter, N. Sato, A. Parker, R. Ashfaq, E. Jaffee, B. Ryu, J. Jones, J.R. Eshleman, C.J. Yeo, J.L. Cameron, S.E. Kern, R.H. Hruban, P.O. Brown and M. Goggins, Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays, Am J Pathol 162 (2003), 1151-1162.
18. H. Friess, J. Ding, J. Kleeff, L. Fenkell, J.A. Rosinski, A. Guweidhi, J.F. Reidhaar-Olson, M. Korc, J. Hammer and M.W.Büchler, Microarry -based identification of differentially expressed growth-and metastasis-associated genes in pancreatic cancer, Cell Mol Life Sci 60 (2003), 1180-1199.
19. C.D. Logsdon, D.M. Simeone, C. Binkley, T. Arumugam, J.K. Greenson, T.J. Giordano, D.E. Misek, R. Kuick and S. Hanash, Molecular profiling of pancreatic adenocarcimoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer, Cancer Res 63 (2003), 2649-2657.
20. M.H. Vaarala, K. Porvari, A. Kyllönen and P. Vihko, Differentially expressed genes in two LNCaP prostate cancer cell lines reflecting changes during prostate cancer progression, Lab Invest 80 (2000), 1259-1268.
21. S. Bibert, D. Aebischer, F. Desgranges, S. Roy, D. Schaer, S. Kharoubl-Hess, J.D. Horisberger and K. Geering, A link between FXYD3(Mat-8)-mediated Na, K-ATPase regulation and differentiation of Caco-2 intestinal epithelial cells, Mol Biol Cell 20 (2009), 1132-1140.
22. G.J. Gordon, W.G. Richards, D.J. Sugarbaker, M.T. Jaklitsch, R. Bueno, A prognostic test for adenocarcinoma of the lung from gene expression profiling data, Cancer Epidemial Biomarkers Prev 12 (2003), 905-910.