Comparative evaluation of the powder and compression properties of various grades and brands of microcrystalline cellulose by multivariate methods

Pharmaceutical Development and Technology

Volumn 15, Issue 4, 2010, Pages 394-404

  Haware, Rahul V ^a   Bauer Brandl, Annette ^a,b   Tho, Ingunn ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

brand variation; direct compression; Microcrystalline cellulose; multivariate analysis; PAT

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; MICROCRYSTALLINE CELLULOSE; CELLULOSE; EXCIPIENT; LUBRICATING AGENT; POWDER; TABLET;

ARTICLE; BULK DENSITY; COMPARATIVE STUDY; FACTORIAL DESIGN; MULTIVARIATE ANALYSIS; PARTIAL LEAST SQUARES REGRESSION; PARTICLE SIZE; POWDER; POWDER DIFFRACTION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SIMULATION; TABLET COMPRESSION; TABLET FORMULATION; TABLET PROPERTY; CHEMISTRY; MEDICINAL CHEMISTRY; REGRESSION ANALYSIS; TABLET;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; LEAST-SQUARES ANALYSIS; LUBRICANTS; MULTIVARIATE ANALYSIS; POWDERS; PRINCIPAL COMPONENT ANALYSIS; TABLETS;

EID: 77953994367     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450903262041     Document Type: Article

References (17)

1. Haware RV, Tho I, Bauer-Brandl A. Application of multivariate methods to compression behavior evaluation of directly compressible materials. Eur J Pharm Sci 2009;72(1): 148-155.
2. Doelker E, Mordier D, Iten H, Humbert-Droz P. Comparative tableting properties of sixteen microcrystalline celluloses. Drug Dev Ind Pharm 1987;13(9-11):1847-1875.
3. Albers J, Knop K, Kleinebudde P. Brand-to-brand and batchto- batch uniformity of microcrystalline cellulose in direct tableting with a pneumohydraulic tablet press. Pharmazeutische Industrie 2006;68(12):1420-1428.
4. Doelker E, Massuelle D, Veuillez F, Humbert-Droz P. Morphological, packing, flow and tableting properties of new Avicel types. Drug Dev Ind Pharm 1995;21(6):643-661.
5. Williams RO, III, Sriwongjanya M, Barron MK. Compaction properties of microcrystalline cellulose using tableting indexes. Drug Dev Ind Pharm 1997;23(7):695-704.
6. Doelker E. Comparative compaction properties of various microcrystalline cellulose types and generic products. Drug Dev Ind Pharm 1993;19(17-18):2399- 2471.
7. Klevan I, Haware RV, Reichenbach M, Bauer-Brandl A. A new tablet press simulator device for extremely accurate measurement of time-resolved forces and displacements based on an electromechanical press. Poster presented at: Pharmaceutical Sciences World Congress, 2007; Amsterdam, The Netherlands.
8. European pharmacopoeia. 6th ed. 2008(6.2);2.9.38:325-327.
9. European pharmacopoeia. 6th ed. 2008(6.2);2.9.15:285-286.
10. Magnesium stearate. In: Wade A, Weller PJ, editors. Handbook of pharmaceutical excipient. 2nd ed. London: The Pharmaceutical Press; 1994:280-282.
11. Ritschel WA, Bauer-Brandl A. Herstellung verpreßbarer tablettiermessen, in Die Tablette. Handbuch der Entwicklung, Herstellung und Qualitätssicherung. Aulendorf: Editio Cantor Verl.: Aulendorf.; 2002:354-355.
12. Newton JM, Rowley G, Fell JT, Peacock DG, Ridgway K. Computer analysis of the relation between tablet strength and compaction pressure. J Pharm Pharmcol 1971;23(Suppl.): 195S-201S.
13. Martens H, Martens M. Modified jack-knife estimation of parameter uncertainty in bilinear modelling by partial least squares regression (PLSR). Food Qual Pref 2000;11:5-16.
14. Martens H, Naes T. Multivariate calibration. Chichester, UK: Wiley and Sons; 1989.
15. Esbensen K, Schoenkopf S, Midtgaard T, Guyot D. Multivariate analysis in practice. Trondheim, Norway: Camo ASA; 1994.
16. Roberts RJ, Rowe RC. The effect of the relationship between punch velocity and particle size on the compaction behavior of materials with varying deformation mechanisms. J Pharm Pharmcol 1986;38(8):567-571.
17. McKenna A, McCafferty DF. Effect on particle size on the compaction mechanism and tensile strength of tablets. J Pharm Pharmacol 1982;34(6):347-351.