The crystal structure of the Y140F mutant of ADP-L-glycero-D-manno-heptose 6-epimerase bound to ADP-β-D-mannose suggests a one base mechanism

Protein Science

Volumn 19, Issue 7, 2010, Pages 1337-1343

  Kowatz, Thomas ^a   Morrison, James P ^b   Tanner, Martin E ^b   Naismith, James H ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Carbohydrate; Hydride transfer; Keto sugar; LPS biosynthesis; SDR enzymes

Indexed keywords

ADENOSINE DIPHOSPHATE; ADP GLYCEROMANNOHEPTOSE; ADP GLYCEROMANNOHEPTOSE 6 EPIMERASE; EPIMERASE; HEPTOSE; LIPOPOLYSACCHARIDE; MANNOSE; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE SUGAR; ADENOSINE DIPHOSPHATE-MANNOSE; ADP-L-GLYCERO-D-MANNOHEPTOSE-6-EPIMERASE; GLYCERO-MANNO-HEPTOSE;

ARTICLE; CARBOHYDRATE SYNTHESIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; EPIMERIZATION; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; BINDING SITE; CHEMISTRY; GENETICS; METABOLISM; MUTATION; PROCEDURES; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ADENOSINE DIPHOSPHATE SUGARS; BINDING SITES; CARBOHYDRATE EPIMERASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HEPTOSES; MUTATION; PROTEIN STRUCTURE, SECONDARY;

EID: 77953969928     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.410     Document Type: Article

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