Ecabet sodium: A potential new agent in the management of distal colitis

Journal of Gastroenterology and Hepatology (Australia)

Volumn 25, Issue 7, 2010, Pages 1182-1184

  Lawrance, Ian C ^a,b  

^a FREMANTLE HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

12 SULFODEHYDROABIETIC ACID; MUCIN; AZATHIOPRINE; CORTICOSTEROID; ECABET; MERCAPTOPURINE; MUCIN 2; ABIETANE DERIVATIVE; ANTIULCER AGENT; MITOGEN ACTIVATED PROTEIN KINASE;

COLITIS; DRUG BINDING; DRUG EFFICACY; DRUG MECHANISM; EDITORIAL; GASTRITIS; GOBLET CELL; INTESTINE EPITHELIUM; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; STOMACH ULCER; WOUND HEALING; ADAPTIVE IMMUNITY; ARTICLE; CELL MIGRATION; ENTEROCOLITIS; GENE MUTATION; HUMAN; INFLAMMATORY BOWEL DISEASE; INTESTINE EPITHELIUM CELL; PROCTITIS; ULCERATIVE COLITIS; ACUTE DISEASE; ANIMAL; CELL MOTION; COLITIS, ULCERATIVE; COLON; DRUG EFFECTS; ENZYMOLOGY; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; PHOSPHORYLATION; RAT;

ACUTE DISEASE; ANIMALS; ANTI-ULCER AGENTS; CELL MOVEMENT; COLITIS, ULCERATIVE; COLON; DITERPENES, ABIETANE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTESTINAL MUCOSA; PHOSPHORYLATION; RATS; WOUND HEALING;

EID: 77953965526     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2010.06339.x     Document Type: Editorial

References (16)

1. Takagi T, Naito Y, Okuda T et al. Ecabet sodium promotes the healing of trinitrobenzene-sulfonic-acid-induced ulceration by enhanced restitution of intestinal epithelial cells. Journal of Gastroenterology and Hepatology 2010 25 : 1259 1265.
2. Morris GP, Beck PL, Herridge MS, Depew WT, Szewczuk MR, Wallace JL. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 1989 96 : 795 803.
3. Lawrance IC, Wu F, Leite AZ et al. A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B. Gastroenterology 2003 125 : 1750 1761.
4. Neurath MF, Fuss I, Kelsall BL, Presky DH, Waegell W, Strober W. Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance. J. Exp. Med. 1996 183 : 2605 2616.
5. Ito Y, Sugawara Y, Takaiti O, Nakamura S. Metabolic fate of a new anti-ulcer drug (+)-(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a- octahydro-1,4a-dimethyl- 7-(1-methylethyl)-6-sulfo-1- phenanthrenecarboxylic acid 6-sodium salt pentahydrate (TA-2711). II. Distribution in the rat stomach. J. Pharmacobiodyn. 1991 14 : 547 554.
6. Ito Y, Onoda Y, Nakamura S et al. Effects of the new anti-ulcer drug ecabet sodium (TA-2711) on pepsin activity. II. Interaction with substrate protein. Jpn. J. Pharmacol. 1993 62 : 175 181. (Pubitemid 23218237)
7. Noto T, Yamada H, Inui T et al. Therapeutic effects of ecabet sodium, an antiulcer drug, on dextran sodium sulfate-induced ulcerative colitis in rats. Dig. Dis. Sci. 2005 50 : 922 927.
8. Kono T, Nomura M, Kasai S, Kohgo Y. Effect of ecabet sodium enema on mildly to moderately active ulcerative proctosigmoiditis: an open-label study. Am. J. Gastroenterol. 2001 96 : 793 797.
9. Monteleone G, Caprioli F. Drug evaluation: TA-2711E in the treatment of active distal ulcerative colitis. Curr. Opin. Investig. Drugs 2007 8 : 423 428.
10. Chino A, Kishihara T, Uragami N et al. Re-epithelialization of squamous epithelium for a radiation-induced rectal ulcer while giving an ecabet sodium enema. Dig. Endosc. 2009 21 : 56 8.
11. Heazlewood CK, Cook MC, Eri R et al. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med. 2008 5 : e54.
12. Powrie F, Leach MW. Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation. Ther. Immunol. 1995 2 : 115 123.
13. Elson CO, Cong Y, McCracken VJ, Dimmitt RA, Lorenz RG, Weaver CT. Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol. Rev. 2005 206 : 260 276.
14. Sartor RB. Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics. Gastroenterology 2004 126 : 1620 1633.
15. Chaturvedi LS, Marsh HM, Shang X, Zheng Y, Basson MD. Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1. J. Biol. Chem. 2007 282 : 14 28.
16. Zhang J, Owen CR, Sanders MA, Turner JR, Basson MD. The motogenic effects of cyclic mechanical strain on intestinal epithelial monolayer wound closure are matrix dependent. Gastroenterology 2006 131 : 1179 1189.