QRS prolongation in myotonic muscular dystrophy and diffuse fibrosis on cardiac magnetic resonance

Magnetic Resonance in Medicine

Volumn 64, Issue 1, 2010, Pages 107-114

  Nazarian, Saman ^a   Bluemke, David A ^d   Wagner, Kathryn R ^b   Zviman, Menekhem M ^a   Turkbey, Evrim ^d   Caffo, Brian S ^b   Shehata, Monda ^a   Edwards, David ^a   Butcher, Barbara ^a   Calkins, Hugh ^a   Berger, Ronald D ^a,c   Halperin, Henry R ^a,c   Tomaselli, Gordon F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c Johns Hopkins University   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Atrioventricular block; Electrocardiography; Magnetic resonance imaging; Myocardial fibrosis; Myotonic muscular dystrophy

Indexed keywords

HEART; IMAGE ENHANCEMENT; MAGNETIC RESONANCE IMAGING; SIGNAL TO NOISE RATIO;

ATRIOVENTRICULAR BLOCK; CARDIAC MAGNETIC RESONANCE; EJECTION FRACTION; MUSCULAR DYSTROPHY; MYOCARDIAL FIBROSIS; POSITIVE PREDICTIVE VALUES; RECEIVER OPERATING CHARACTERISTIC CURVES; SPATIAL HETEROGENEITY;

ELECTROCARDIOGRAPHY;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; DISEASE ASSOCIATION; ECG ABNORMALITY; ELECTROCARDIOGRAPHY; FEMALE; HEART EJECTION FRACTION; HEART LEFT VENTRICLE; HEART MUSCLE FIBROSIS; HUMAN; MALE; MYOTONIC DYSTROPHY; NUCLEAR MAGNETIC RESONANCE; PREDICTIVE VALIDITY; QRS COMPLEX; RECEIVER OPERATING CHARACTERISTIC; SIGNAL AVERAGED ELECTROCARDIOGRAPHY; SIGNAL NOISE RATIO; ARTIFACT; HEART BUNDLE BRANCH BLOCK; HEART VENTRICLE; MIDDLE AGED; MORTALITY; MUSCULAR DYSTROPHY; PATHOPHYSIOLOGY; PREDICTIVE VALUE; PROCEDURES; RADIOGRAPHY;

CONTRAST MEDIUM;

ADULT; ARTIFACTS; BUNDLE-BRANCH BLOCK; CONTRAST MEDIA; ELECTROCARDIOGRAPHY; FEMALE; HEART VENTRICLES; HUMANS; MALE; MIDDLE AGED; MUSCULAR DYSTROPHIES; MYOTONIC DYSTROPHY; PREDICTIVE VALUE OF TESTS;

EID: 77953944174     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22417     Document Type: Article

References (33)

1. Ashizawa T, Epstein HF. Ethnic distribution of myotonic dystrophy gene. Lancet 1991;338:642-643.
2. Groh WJ, Groh MR, Saha C, Kincaid JC, Simmons Z, Ciafaloni E, Pourmand R, Otten RF, Bhakta D, Nair GV, Marashdeh MM, Zipes DP, Pascuzzi RM. Electrocardiographic abnormalities and sudden death in myotonic dystrophy type 1. N Engl J Med 2008;358: 2688-2697.
3. Brook JD, McCurrach ME, Harley HG, Buckler AJ, Church D, Aburatani H, Hunter K, Stanton VP, Thirion JP, Hudson T, et al. Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member. Cell 1992;68:799-808.
4. Liquori CL, Ricker K, Moseley ML, Jacobsen JF, Kress W, Naylor SL, Day JW, Ranum LP. Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9. Science 2001;293:864-867.
5. Ludatscher RM, Kerner H, Amikam S, Gellei B. Myotonia dystrophica with heart involvement: an electron microscopic study of skeletal, cardiac, and smooth muscle. J Clin Pathol 1978;31:1057-1064. (Pubitemid 9068632)
6. Motta J, Guilleminault C, Billingham M, Barry W, Mason J. Cardiac abnormalities in myotonic dystrophy: electrophysiologic and histopathologic studies. Am J Med 1979;67:467-473. (Pubitemid 10237032)
7. Grigg LE, Chan W, Mond HG, Vohra JK, Downey WF. Ventricular tachycardia and sudden death in myotonic dystrophy: clinical, electrophysiologic and pathologic features. J Am Coll Cardiol 1985;6: 254-256. (Pubitemid 15069274)
8. Nguyen HH, Wolfe JT 3rd, Holmes DR Jr, Edwards WD. Pathology of the cardiac conduction system in myotonic dystrophy: a study of 12 cases. J Am Coll Cardiol 1988;11:662-671.
9. Bello D, Fieno DS, Kim RJ, Pereles FS, Passman R, Song G, Kadish AH, Goldberger JJ. Infarct morphology identifies patients with substrate for sustained ventricular tachycardia. J Am Coll Cardiol 2005; 45:1104-1108. (Pubitemid 40432446)
10. Nazarian S, Bluemke DA, Lardo AC, Zviman MM, Watkins SP, Dickfeld TL, Meininger GR, Roguin A, Calkins H, Tomaselli GF, Weiss RG, Berger RD, Lima JA, Halperin HR. Magnetic resonance assessment of the substrate for inducible ventricular tachycardia in nonischemic cardiomyopathy. Circulation 2005;112:2821-2825.
11. Yan AT, Shayne AJ, Brown KA, Gupta SN, Chan CW, Luu TM, Di Carli MF, Reynolds HG, Stevenson WG, Kwong RY. Characterization of the peri-infarct zone by contrast-enhanced cardiac magnetic resonance imaging is a powerful predictor of post-myocardial infarction mortality. Circulation 2006;114:32-39.
12. Assomull RG, Prasad SK, Lyne J, Smith G, Burman ED, Khan M, Sheppard MN, Poole-Wilson PA, Pennell DJ. Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy. J Am Coll Cardiol 2006;48:1977-1985. (Pubitemid 44738448)
13. Schmidt A, Azevedo CF, Cheng A, Gupta SN, Bluemke DA, Foo TK, Gerstenblith G, Weiss RG, Marban E, Tomaselli GF, Lima JA, Wu KC. Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation 2007;115:2006-2014. (Pubitemid 46625951)
14. Iles L, Pfluger H, Phrommintikul A, Cherayath J, Aksit P, Gupta SN, Kaye DM, Taylor AJ. Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping. J Am Coll Cardiol 2008;52:1574-1580.
15. Schuijf JD, Kaandorp TA, Lamb HJ, van der Geest RJ, Viergever EP, van der Wall EE, de Roos A, Bax JJ. Quantification of myocardial infarct size and transmurality by contrast-enhanced magnetic resonance imaging in men. Am J Cardiol 2004;94:284-288. (Pubitemid 38962690)
16. Griggs RC, Davis RJ, Anderson DC, Dove JT. Cardiac conduction in myotonic dystrophy. Am J Med 1975;59:37-42.
17. Hiromasa S, Ikeda T, Kubota K, Hattori N, Nishimura M, Watanabe Y, Maldonado C, Palakurthy PR, Kupersmith J. Myotonic dystrophy: ambulatory electrocardiogram, electrophysiologic study, and echocardiographic evaluation. Am Heart J 1987;113:1482-1488.
18. Olofsson BO, Forsberg H, Andersson S, Bjerle P, Henriksson A, Wedin I. Electrocardiographic findings in myotonic dystrophy. Br Heart J 1988;59:47-52.
19. Melacini P, Buja G, Fasoli G, Angelini C, Armani M, Scognamiglio R, Dalla Volta S. The natural history of cardiac involvement in myotonic dystrophy: an eight-year follow-up in 17 patients. Clin Cardiol 1988;11:231-238.
20. Phillips MF, Harper PS. Cardiac disease in myotonic dystrophy. Cardiovasc Res 1997;33:13-22.
21. Wang GS, Kearney DL, De Biasi M, Taffet G, Cooper TA. Elevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy. J Clin Invest 2007;117:2802-2811.
22. Wakimoto H, Maguire CT, Sherwood MC, Vargas MM, Sarkar PS, Han J, Reddy S, Berul CI. Characterization of cardiac conduction system abnormalities in mice with targeted disruption of Six5 gene. J Interv Card Electrophysiol 2002;7:127-135.
23. Clarke NR, Kelion AD, Nixon J, Hilton-Jones D, Forfar JC. Does cytosine-thymine-guanine (CTG) expansion size predict cardiac events and electrocardiographic progression in myotonic dystrophy? Heart 2001;86:411-416.
24. Sabovic M, Medica I, Logar N, Mandic E, Zidar J, Peterlin B. Relation of CTG expansion and clinical variables to electrocardiogram conduction abnormalities and sudden death in patients with myotonic dystrophy. Neuromuscul Disord 2003;13:822-826. (Pubitemid 37532732)
25. Ranum LP, Day JW. Myotonic dystrophy: clinical and molecular parallels between myotonic dystrophy type 1 and type 2. Curr Neurol Neurosci Rep 2002;2:465-470.
26. Schoser BG, Ricker K, Schneider-Gold C, Hengstenberg C, Durre J, Bultmann B, Kress W, Day JW, Ranum LP. Sudden cardiac death in myotonic dystrophy type 2. Neurology 2004;63:2402-2404. (Pubitemid 40024362)
27. Lazarus A, Varin J, Babuty D, Anselme F, Coste J, Duboc D. Long-term follow-up of arrhythmias in patients with myotonic dystrophy treated by pacing: a multicenter diagnostic pacemaker study. J Am Coll Cardiol 2002;40:1645-1652. (Pubitemid 35253643)
28. Hawley RJ, Colleran JA, Fletcher R, Verdino RJ, Kokkinos P, Pinnow E. Indications for cardiac pacemaker implantation in myotonic dystrophy. MedGenMed 1999;Sep 7:E5.
29. Pelargonio G, Dello Russo A, Sanna T, De Martino G, Bellocci F. Myotonic dystrophy and the heart. Heart 2002;88:665-670.
30. Sovari AA, Bodine CK, Farokhi F. Cardiovascular manifestations of myotonic dystrophy-1. Cardiol Rev 2007;15:191-194.
31. Colleran JA, Hawley RJ, Pinnow EE, Kokkinos PF, Fletcher RD. Value of the electrocardiogram in determining cardiac events and mortality in myotonic dystrophy. Am J Cardiol 1997;80:1494-1497.
32. Segawa I, Suzuki T, Kato M, Tashiro A, Satodate R. Relation between myocardial histological changes and ventricular tachycardia in cardiomyopathy: a study by 24-hour ECG-monitoring and endomyocardial biopsy. Heart Vessels Suppl 1990;5:37-40.
33. Strain JE, Grose RM, Factor SM, Fisher JD. Results of endomyocardial biopsy in patients with spontaneous ventricular tachycardia but without apparent structural heart disease. Circulation 1983;68:1171-1181.