메뉴 건너뛰기




Volumn 151, Issue 6, 2010, Pages 2898-2910

Male 41, XXY* mice as a model for Klinefelter syndrome: Hyperactivation of Leydig cells

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; FOLLITROPIN; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR; MESSENGER RNA; TESTOSTERONE;

EID: 77953941607     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-1396     Document Type: Article
Times cited : (46)

References (53)
  • 1
    • 0033616220 scopus 로고    scopus 로고
    • Sex determination and the Y chromosome
    • McElreavey K, Fellous M 1999 Sex determination and the Y chromosome. Am J Med Genet 89:176-185
    • (1999) Am J Med Genet , vol.89 , pp. 176-185
    • McElreavey, K.1    Fellous, M.2
  • 4
    • 0242472011 scopus 로고    scopus 로고
    • Clinical and diagnostic features of patients with suspected Klinefelter syndrome
    • Kamischke A, Baumgardt A, Horst J, Nieschlag E 2003 Clinical and diagnostic features of patients with suspected Klinefelter syndrome. J Androl 24:41-48
    • (2003) J Androl , vol.24 , pp. 41-48
    • Kamischke, A.1    Baumgardt, A.2    Horst, J.3    Nieschlag, E.4
  • 8
    • 34548776061 scopus 로고    scopus 로고
    • Clinical, endocrinological, and epigenetic features of the 46,XX male syndrome, compared with 47,XXY Klinefelter patients
    • Vorona E, Zitzmann M, Gromoll J, Schüring AN, Nieschlag E 2007 Clinical, endocrinological, and epigenetic features of the 46,XX male syndrome, compared with 47,XXY Klinefelter patients. J Clin Endocrinol Metab 92:3458-3465
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3458-3465
    • Vorona, E.1    Zitzmann, M.2    Gromoll, J.3    Schüring, A.N.4    Nieschlag, E.5
  • 10
    • 33646059921 scopus 로고    scopus 로고
    • Morbidity in Klinefelter syndrome: A Danish register study based on hospital discharge diagnoses
    • Bojesen A, Juul S, Birkebaek NH, Gravholt CH 2006 Morbidity in Klinefelter syndrome: a Danish register study based on hospital discharge diagnoses. J Clin Endocrinol Metab 91:1254-1260
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1254-1260
    • Bojesen, A.1    Juul, S.2    Birkebaek, N.H.3    Gravholt, C.H.4
  • 12
    • 0025921769 scopus 로고
    • Chromosome abnormalities found among 34,910 newborn children: Results from a 13-year incidence study in Arhus, Denmark
    • Nielsen J, Wohlert M 1991 Chromosome abnormalities found among 34,910 newborn children: results from a 13-year incidence study in Arhus, Denmark. Hum Genet 87:81-83
    • (1991) Hum Genet , vol.87 , pp. 81-83
    • Nielsen, J.1    Wohlert, M.2
  • 13
    • 0025922098 scopus 로고
    • Cytogenetic studies in male infertility: A review
    • De Braekeleer M, Dao TN 1991 Cytogenetic studies in male infertility: a review. Hum Reprod 6:245-250
    • (1991) Hum Reprod , vol.6 , pp. 245-250
    • De Braekeleer, M.1    Dao, T.N.2
  • 14
    • 0030880012 scopus 로고    scopus 로고
    • Sexual function and clinical features of patients with Klinefelter's syndrome with the chief complaint of male infertility
    • Yoshida A, Miura K, Nagao K, Hara H, Ishii N, Shirai M 1997 Sexual function and clinical features of patients with Klinefelter's syndrome with the chief complaint of male infertility. Int J Androl 20:80-85
    • (1997) Int J Androl , vol.20 , pp. 80-85
    • Yoshida, A.1    Miura, K.2    Nagao, K.3    Hara, H.4    Ishii, N.5    Shirai, M.6
  • 15
    • 0037326355 scopus 로고    scopus 로고
    • Longitudinal studies of inhibin B levels in boys and young adults with Klinefelter syndrome
    • Christiansen P, Andersson AM, Skakkebaek NE 2003 Longitudinal studies of inhibin B levels in boys and young adults with Klinefelter syndrome. J Clin Endocrinol Metab 88:888-891
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 888-891
    • Christiansen, P.1    Andersson, A.M.2    Skakkebaek, N.E.3
  • 17
    • 63449115550 scopus 로고    scopus 로고
    • Nonobstructive azoospermia: A revolutionary surgical approach and results
    • Schlegel PN 2009 Nonobstructive azoospermia: a revolutionary surgical approach and results. Semin Reprod Med 27:165-170
    • (2009) Semin Reprod Med , vol.27 , pp. 165-170
    • Schlegel, P.N.1
  • 22
    • 0026356506 scopus 로고
    • Comparative effects of chronic administration of the nonsteroidal antiandrogens flutamide and Casodex on the reproductive system of the adult male rat
    • Copenh
    • Chandolia RK, Weinbauer GF, Simoni M, Behre HM, Nieschlag E 1991 Comparative effects of chronic administration of the nonsteroidal antiandrogens flutamide and Casodex on the reproductive system of the adult male rat. Acta Endocrinol (Copenh) 125:547-555
    • (1991) Acta Endocrinol , vol.125 , pp. 547-555
    • Chandolia, R.K.1    Weinbauer, G.F.2    Simoni, M.3    Behre, H.M.4    Nieschlag, E.5
  • 24
    • 0034026589 scopus 로고    scopus 로고
    • Development of time-resolved immunofluorometric assays for rat follicle-stimulating hormone and luteinizing hormone and application on sera of cycling rats
    • van Casteren JI, Schoonen WG, Kloosterboer HJ 2000 Development of time-resolved immunofluorometric assays for rat follicle-stimulating hormone and luteinizing hormone and application on sera of cycling rats. Biol Reprod 62:886-894
    • (2000) Biol Reprod , vol.62 , pp. 886-894
    • Van Casteren, J.I.1    Schoonen, W.G.2    Kloosterboer, H.J.3
  • 25
    • 0037331657 scopus 로고    scopus 로고
    • Intrauterine bisphenol A exposure leads to stimulatory effects on Sertoli cell number in rats
    • Wistuba J, Brinkworth MH, Schlatt S, Chahoud I, Nieschlag E 2003 Intrauterine bisphenol A exposure leads to stimulatory effects on Sertoli cell number in rats. Environ Res 91:95-103
    • (2003) Environ Res , vol.91 , pp. 95-103
    • Wistuba, J.1    Brinkworth, M.H.2    Schlatt, S.3    Chahoud, I.4    Nieschlag, E.5
  • 26
    • 0021234096 scopus 로고
    • The unbiased estimation of number and sizes of arbitrary particles using the dissector
    • Sterio DC 1984 The unbiased estimation of number and sizes of arbitrary particles using the dissector. J Microsc 134:127-136
    • (1984) J Microsc , vol.134 , pp. 127-136
    • Sterio, D.C.1
  • 27
    • 84985187820 scopus 로고
    • Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson
    • Gundersen HJ 1986 Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J Microsc 143:3-45
    • (1986) J Microsc , vol.143 , pp. 3-45
    • Gundersen, H.J.1
  • 28
    • 0028832450 scopus 로고
    • Theory and practice of stereological techniques applied to the estimation of cell number and nuclear volume in the testis
    • Wreford NG 1995 Theory and practice of stereological techniques applied to the estimation of cell number and nuclear volume in the testis. Microsc Res Tech 32:423-436
    • (1995) Microsc Res Tech , vol.32 , pp. 423-436
    • Wreford, N.G.1
  • 29
    • 0030034051 scopus 로고    scopus 로고
    • XIST RNA paints the inactive X chromosome at interphase: Evidence for a novel RNA involved in nuclear/chromosome structure
    • Clemson CM, McNeil JA, Willard HF, Lawrence JB 1996 XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure. J Cell Biol 132:259-275
    • (1996) J Cell Biol , vol.132 , pp. 259-275
    • Clemson, C.M.1    McNeil, J.A.2    Willard, H.F.3    Lawrence, J.B.4
  • 30
    • 0030880815 scopus 로고    scopus 로고
    • 1997X chromosome inactivation is mediated by Xist RNA stabilization
    • Panning B, Dausman J, Jaenisch R 1997X chromosome inactivation is mediated by Xist RNA stabilization. Cell 90:907-916
    • Cell , vol.90 , pp. 907-916
    • Panning, B.1    Dausman, J.2    Jaenisch, R.3
  • 31
    • 0029956442 scopus 로고    scopus 로고
    • DNA hypomethylation can activate Xist expression and silence X-linked genes
    • Panning B, Jaenisch R 1996 DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev 10:1991-2002
    • (1996) Genes Dev , vol.10 , pp. 1991-2002
    • Panning, B.1    Jaenisch, R.2
  • 32
    • 0017690668 scopus 로고
    • Isolation of highly purified Leydig cells by density gradient centrifugation
    • Conn PM, Tsuruhara T, Dufau M, Catt KJ 1977 Isolation of highly purified Leydig cells by density gradient centrifugation. Endocrinology 101:639-642
    • (1977) Endocrinology , vol.101 , pp. 639-642
    • Conn, P.M.1    Tsuruhara, T.2    Dufau, M.3    Catt, K.J.4
  • 33
    • 0018104459 scopus 로고
    • Rapid isolation of mouse Leydig cells by centrifugation in Percoll density gradients with complete retention of morphological and biochemical integrity
    • Schumacher M, Schäfer G, Holstein AF, Hilz H 1978 Rapid isolation of mouse Leydig cells by centrifugation in Percoll density gradients with complete retention of morphological and biochemical integrity. FEBS Lett 91:333-338
    • (1978) FEBS Lett , vol.91 , pp. 333-338
    • Schumacher, M.1    Schäfer, G.2    Holstein, A.F.3    Hilz, H.4
  • 34
    • 0017652621 scopus 로고
    • Activity of Δ5,3β-hydroxysteroid dehydrogenase in cultured interstitial cells of mouse testes
    • Bilińska B, Stoklosowa S 1977 Activity of Δ5,3β- hydroxysteroid dehydrogenase in cultured interstitial cells of mouse testes. Endocrinol Exp 11:169-174
    • (1977) Endocrinol Exp , vol.11 , pp. 169-174
    • Bilińska, B.1    Stoklosowa, S.2
  • 35
    • 0025822943 scopus 로고
    • Separation and characterization of Leydig cells and macrophages from rat testes
    • Dirami G, Poulter LW, Cooke BA 1991 Separation and characterization of Leydig cells and macrophages from rat testes. J Endocrinol 130:357-365
    • (1991) J Endocrinol , vol.130 , pp. 357-365
    • Dirami, G.1    Poulter, L.W.2    Cooke, B.A.3
  • 36
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2[-ΔΔC(T)] method
    • Livak KJ, Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2[-ΔΔC(T)] method. Methods 25:402-408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 37
    • 0036195674 scopus 로고    scopus 로고
    • Changes in Leydig cell gene expression during development in the mouse
    • O'Shaughnessy PJ, Willerton L, Baker PJ 2002 Changes in Leydig cell gene expression during development in the mouse. Biol Reprod 66:966-975
    • (2002) Biol Reprod , vol.66 , pp. 966-975
    • O'Shaughnessy, P.J.1    Willerton, L.2    Baker, P.J.3
  • 38
    • 0021733481 scopus 로고
    • Leydig cell function in the absence of an intact Y chromosome
    • Chubb C, Nolan C 1984 Leydig cell function in the absence of an intact Y chromosome. Biol Reprod 31:536-540
    • (1984) Biol Reprod , vol.31 , pp. 536-540
    • Chubb, C.1    Nolan, C.2
  • 40
    • 73949144105 scopus 로고    scopus 로고
    • 2010 Severe XIST hypomethylation clearly distinguishes (SRY+) 46,XX-maleness from Klinefelter syndrome
    • Poplinski A, Wieacker P, Kliesch S, Gromoll J 2010 Severe XIST hypomethylation clearly distinguishes (SRY+) 46,XX-maleness from Klinefelter syndrome. Eur J Endocrinol 162:169-175
    • Eur J Endocrinol , vol.162 , pp. 169-175
    • Poplinski, A.1    Wieacker, P.2    Kliesch, S.3    Gromoll, J.4
  • 41
    • 57649148571 scopus 로고    scopus 로고
    • Fertility in a i(Xq) Klinefelter patient: Importance of XIST expression level determined by qRT-PCR in ruling out Klinefelter cryptic mosaicism as cause of oligozoospermia
    • Stabile M, Angelino T, Caiazzo F, Olivieri P, De Marchi N, De Petrocellis L, Orlando P 2008 Fertility in a i(Xq) Klinefelter patient: importance of XIST expression level determined by qRT-PCR in ruling out Klinefelter cryptic mosaicism as cause of oligozoospermia. Mol Hum Reprod 14:635-640
    • (2008) Mol Hum Reprod , vol.14 , pp. 635-640
    • Stabile, M.1    Angelino, T.2    Caiazzo, F.3    Olivieri, P.4    De Marchi, N.5    De Petrocellis, L.6    Orlando, P.7
  • 42
    • 0033808644 scopus 로고    scopus 로고
    • Chromosomal domains and escape from X inactivation: Comparative X inactivation analysis in mouse and human
    • Tsuchiya KD, Willard HF 2000 Chromosomal domains and escape from X inactivation: comparative X inactivation analysis in mouse and human. Mamm Genome 11:849-854
    • (2000) Mamm Genome , vol.11 , pp. 849-854
    • Tsuchiya, K.D.1    Willard, H.F.2
  • 43
    • 15244353967 scopus 로고    scopus 로고
    • X-inactivation profile reveals extensive variability in X-linked gene expression in females
    • Carrel L, Willard HF 2005 X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 434:400-404
    • (2005) Nature , vol.434 , pp. 400-404
    • Carrel, L.1    Willard, H.F.2
  • 44
    • 0042706143 scopus 로고    scopus 로고
    • A stain upon the silence: Genes escaping X inactivation
    • Brown CJ, Greally JM 2003 A stain upon the silence: genes escaping X inactivation. Trends Genet 19:432-438
    • (2003) Trends Genet , vol.19 , pp. 432-438
    • Brown, C.J.1    Greally, J.M.2
  • 46
    • 0018599868 scopus 로고
    • Effect of age on testicular function in patients with Klinefelter's syndrome
    • Oxf
    • Gabrilove JL, Freiberg EK, Thornton JC, Nicolis GL 1979 Effect of age on testicular function in patients with Klinefelter's syndrome. Clin Endocrinol (Oxf) 11:343-347
    • (1979) Clin Endocrinol , vol.11 , pp. 343-347
    • Gabrilove, J.L.1    Freiberg, E.K.2    Thornton, J.C.3    Nicolis, G.L.4
  • 48
    • 0029021639 scopus 로고
    • Turner syndrome and female sex chromosome aberrations: Deduction of the principal factors involved in the development of clinical features
    • Ogata T, Matsuo N 1995 Turner syndrome and female sex chromosome aberrations: deduction of the principal factors involved in the development of clinical features. Hum Genet 95:607-629
    • (1995) Hum Genet , vol.95 , pp. 607-629
    • Ogata, T.1    Matsuo, N.2
  • 51
    • 0016215654 scopus 로고
    • The effect of short and long term human chorionic gonadotrophin (HCG) administration on plasma testosterone levels in Klinefelter's syndrome
    • Copenh
    • Smals AG, Kloppenborg PW, Benraad TJ 1974 The effect of short and long term human chorionic gonadotrophin (HCG) administration on plasma testosterone levels in Klinefelter's syndrome. Acta Endocrinol (Copenh) 77:753-764
    • (1974) Acta Endocrinol , vol.77 , pp. 753-764
    • Smals, A.G.1    Kloppenborg, P.W.2    Benraad, T.J.3
  • 53
    • 0034908014 scopus 로고    scopus 로고
    • Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice
    • Baker PJ, O'Shaughnessy PJ 2001 Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice. Reproduction 122:227-234
    • (2001) Reproduction , vol.122 , pp. 227-234
    • Baker, P.J.1    O'Shaughnessy, P.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.