How an eukaryotic cell senses the substrate stiffness? An exploration using a finite element model with cytoskeleton modelled as tensegrity structure

Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009

Volumn , Issue PART A, 2009, Pages 559-560

  De Santis, Gianluca ^a   Boschetti, Federica ^b   Lennon, Alex B ^c   Prendergast, Patrick J ^c   Verdonck, Pascal ^a   Verhegghe, Benedict ^a  

^a GHENT UNIVERSITY   (Belgium)

^b POLITECNICO DI MILANO   (Italy)

^c TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77953933174     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1115/SBC2009-206448     Document Type: Conference Paper

References (5)

1. Yeung T, Georges PC, Flanagan LA, Marg B, Ortiz M, Funaki M, Zahir N, Ming W, Weaver V, Janmey PA, 2005. Effects of Substrate Stiffness on Cell Morphology, Cytoskeletal Structure and Adhesion. Cell Motility and the Cytoskeleton 60:24-34.
2. Georges PC, Janmey PA, 2005. Cell type-specific response to growth on soft materials. J Appl Physiol. 98: 1547-1553.
3. Ingber DE, 1997. Tensegrity: The architectural basis of cellular mechanotransduction. Annu. Rev. Physiol. 59: 575-599.
4. Ingber DE, 2003. Tensegrity I. Cell structure and hierarchical systems biology. J. Cell Sci. 116: 1157-1173.
5. McGarry JG, Prendergast PJ, 2004. A three-dimensional finite element model of an adherent eukaryotic cell. Eur. Cells Mater. 7:27-34.