Targeting and retention of HPV16 E7 to the endoplasmic reticulum enhances immune tumour protection

Journal of Cellular and Molecular Medicine

Volumn 14, Issue 4, 2010, Pages 890-894

  Loera Arias, M J ^a   Martinez Perez A G ^a   Barrera Hernandez A ^a   Ibarra Obregon E R ^a   Gonzalez Saldivar G ^a   Martinez Ortega J I ^a   Rosas Taraco, A ^b   Villanueva Olivo, A ^a   Esparza Gonzalez S C ^a   Villatoro Hernandez, J ^a   Saucedo Cardenas O ^a,c   Montes de Oca Luna, R ^a  

^a Medicina UANL   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

^c INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

Calreticulin; Cancer immunotherapy; Endoplasmic reticulum; HPV16; KDEL sequence; Signal peptide

Indexed keywords

ADENOVIRIDAE; MUS;

EID: 77953931926     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00934.x     Document Type: Article

References (18)

1. Purcell AW, Elliott T. Molecular machinations of the MHC-I peptide loading complex. Curr Opin Immunol 2008, 20:75-81.
2. Yewdell JW. Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing. Trends Cell Biol 2001, 11:294-7.
3. Kageshita T, Hirai S, Ono T. Down-regulation of HLA class I antigen-processing molecules in malignant melanoma: association with disease progression. Am J Pathol 1999, 154:745-54.
4. Cheng WF, Hung CF, Chai CY. Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen. J Clin Invest 2001, 108:669-78.
5. Hsieh CJ, Kim TW, Hung CF. Enhancement of vaccinia vaccine potency by linkage of tumor antigen gene to gene encoding calreticulin. Vaccine 2004, 22:3993-4001.
6. Gomez-Gutierrez JG, Elpek KG, Montes de Oca-Luna R. Vaccination with an adenoviral vector expressing calreticulin-human papillomavirus 16 E7 fusion protein eradicates E7 expressing established tumors in mice. Cancer Immunol Immunother 2007, 56:997-1007.
7. Wada I, Rindress D, Cameron PH. SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane. J Biol Chem 1991, 266:19599-610.
8. Kim JW, Hung CF, Juang J. Comparison of HPV DNA vaccines employing intracellular targeting strategies. Gene Ther 2004, 11:1011-8.
9. Peng S, Tomson TT, Trimble C. A combination of DNA vaccines targeting human papillomavirus type 16 E6 and E7 generates potent antitumor effects. Gene Ther 2006, 13:257-65.
10. Cheng WF, Chen LK, Chen CA. Chimeric DNA vaccine reverses morphine-induced immunosuppression and tumorigenesis. Mol Ther 2006, 13:203-10.
11. Tseng CW, Hung CF, Alvarez RD. Pretreatment with cisplatin enhances E7-specific CD8+ T-Cell-mediated antitumor immunity induced by DNA vaccination. Clin Cancer Res 2008, 14:3185-92.
12. Peng S, Trimble C, Alvarez RD. Cluster intradermal DNA vaccination rapidly induces E7-specific CD8+ T-cell immune responses leading to therapeutic antitumor effects. Gene Ther 2008, 15:1156-66.
13. Yin R, Zheng W, Hao F. HPV16E7 tumor antigen modified by KDEL sequence induce specific cytotoxic T lymphocytes-dependent antitumor immunity. J Dermatol Sci 2009, 55:116-22.
14. Sherritt M, Cooper L, Moss DJ. Immunization with tumor-associated epitopes fused to an endoplasmic reticulum translocation signal sequence affords protection against tumors with down-regulated expression of MHC and peptide transporters. Int Immunol 2001, 13:265-71.
15. Leifert JA, Rodriguez-Carreno MP, Rodriguez F. Targeting plasmid-encoded proteins to the antigen presentation pathways. Immunol Rev 2004, 199:40-53.
16. Michalak M, Corbett EF, Mesaeli N. Calreticulin: one protein, one gene, many functions. Biochem J 1999, 344:281-92.
17. Park YS, Lee JH, Hung CF. Enhancement of antibody responses to Bacillus anthracis protective antigen domain IV by use of calreticulin as a chimeric molecular adjuvant. Infect Immun 2008, 76:1952-9.
18. Kim TW, Lee JH, Hung CF. Generation and characterization of DNA vaccines targeting the nucleocapsid protein of severe acute respiratory syndrome coronavirus. J Virol 2004, 78:4638-45.