Assessment of acute toxicity and reproductive capability of a herbal combination

Pakistan Journal of Pharmaceutical Sciences

Volumn 23, Issue 3, 2010, Pages 291-294

  Riaz, Azra ^a   Khan, Rafeeq Alam ^a   Ahmed, Shadab ^a   Afroz, Syeda ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

Acute oral toxicity; Argyreia speciosa; Mucuna pruriens; Reproductive capability; Tribulus terrestris; Withania somnifera

Indexed keywords

ARGYREIA SPECIOSA EXTRACT; DIMETHYL SULFOXIDE; FERTILITY PROMOTING AGENT; HERBACEOUS AGENT; MUCUNA PRURIENS EXTRACT; TRIBULUS TERRESTRIS EXTRACT; UNCLASSIFIED DRUG; WITHANIA SOMNIFERA EXTRACT;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ARGYREIA SPECIOSA; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; FERTILITY; LD 50; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; REPRODUCTION; TRIBULUS TERRESTRIS; VELVET BEAN; WITHANIA SOMNIFERA;

ANIMALS; FEMALE; FERTILITY; LETHAL DOSE 50; MALE; MICE; PHYTOTHERAPY; PLANTS, MEDICINAL; PREGNANCY; REPRODUCTION;

EID: 77953911210     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Akerele O (1993). Summary of WHO guidelines for the assessment of herbal medicines. Herbal Gram, 28: 13-19.
2. Aphale AA, Chhibba AD and Kumbhaakarna NR (1998). Subacute toxicity study of the combination of ginseng (Panex ginseng) and ashwagandha (Withania somnifera) in rats: a safety assessment. Indian J. Physiol. Pharmacol., 42: 299-302.
3. Archana R and Namasivayam A (1999). Antistressor effect of Withania somnifera. J. Ethnopharmacol., 64: 91-93.
4. Arsyad KM (1996). Effect of protodioscin on the quantity and quality of sperms from males with moderate idiopathic oligozoospermia. Medika, 22: 614-618.
5. Aslani MR, Movassaghi AR, Mohri M, Pedram M and Abavisani A (2003). Experimental Tribulus terrestris Poisoning in sheep: Clinical, laboratory and pathological finding. Vet. Res. Commun., 1: 53-62. (Pubitemid 36240394)
6. Bhattacharya A, Ghosal S and Bhattacharya SK (2001). Antioxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum. J. Ethnopharmacol., 74: 1-6. (Pubitemid 32008512)
7. Bhattacharya SK (1995). Compromised reproductive function-restoring eEffect. Phytotherapy Research, 9: 110-113.
8. Burns MM (2000). Alternative medicine: Herbal preparation. Clin. Ped. Emerg. Med., 1: 186-190.
9. Chandra A and Stephen EH (1998). Impaired fecundity in the United States: 1982-1995. Fam. Plann. Perspect., 30: 34-42.
10. Dhan P, Abhishek N and Tewari SK (2001). Nutritional properties of Mucuna pruriens. International Journal of Food, Science and Nutrition, 52: 79-82.
11. Eisenberg DM, Davis RB, Ettner SL, Susan LE, Scott A, Wilkey S, Rompay MV and Kersler RC (1998). Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA, 280: 1569-1575. (Pubitemid 28520643)
12. FDA, Guidelines for Reproduction Studies FDA/CFSAN Redbook 2000 IV.C.9.a.
13. Gagnier JJ, DeMelo J, Boon H, Rochon P and Bombardier C (2006). Quality of reporting of randomized controlled trials of herbal medicine interventions. Am. J. Med., 119: 1-11. (Pubitemid 44308469)
14. Gauthaman K and Ganesan AP (2008). The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction - an evaluation using primates, rabbit and rat. Phytomedicine, 15: 44-54.
15. Gauthaman K, Adaikan PG and Prasad RN (2002). Aphrodisiac properties of Tribulus terrestris extract (Protodioscin) in normal and castrated rats. Life Sciences, 71: 1385-1396. (Pubitemid 34786283)
16. Gauthaman K, Adaikan PG and Prasad RN (2002). Aphrodisiac properties of Tribulus terrestris in normal and castrated rats. Life Science, 71: 1385-1396.
17. Gauthaman K, Ganesan AP and Prasad RN (2003). Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): An evaluation using a rat model. Journal of Alternative and Complementary Medicine, 9: 257-265. (Pubitemid 36506122)
18. Glatstein IZ, Harlow BL and Hornstein MD (1998). Practice patterns among reproductive endocrinologists: further aspects of the infertility evaluation. Fertil Steril, 70: 263-269.
19. Gokhale AB, Damre AS, Kulkami KR and Saraf MN (2002). Preliminary evaluation of anti-inflammatory and anti-arthritic activity of S. lappa, A. speciosa and A. aspera. Phytomedicine, 9: 433-437.
20. Gurib-Fakim A (2006). Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol. Aspects Med, 27: 1-93.
21. Horwards SS (1995). Current concepts: Treatment of male infertility. New England J. Med., 332: 312-317.
22. Jaleel CA, Gopi R, Manivannan P and Panneerselvam R (2008). Exogenous application of triadimefon affects the antioxidant defense system of Withania somnifera Dunal. Pesticide Biochemistry and Physiology, 91: 170-174.
23. Lorke D (1983). A new approach to practical acute toxicity testing. Archive of Toxicology, 54: 275-287. (Pubitemid 14205493)
24. Mahdi AA, Shankwar SN and Ahmad MK (2008). Effect of Mucuna pruriens on hormonal status and Semen quality in infertile males. Contraception, 78: 167-195.
25. Martino-Andrade AJ, Morais RN, Spercoski KM, Rossi SC, Vechi MF, Golin M, Lombardi NF, Greca CS, Dalsenter PR (2009). Effects of Tribulus terrestris on endocrine sensitive organs in male and female Wistar rats. Journal of Ethnopharmacology, (In Press).
26. McKay DL and Blumberg JB (2007). A review of the bioactivity of South African herbal teas: Roobos (Aspalathus linearis) and Honey comb (Cyclopia intermedia). Phytother. Res., 21: 1-16.
27. Mishra L, Singh BB, Dagenais S (2000). Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): A review. Alter. Med., 5: 334-346.
28. Mohanty IR, Dharamvir SA and Gupta SK (2008). Withania somnifera provides cardioprotection and attenuates ischemiaereperfusion induced apoptosis. Clinical Nutrition, 27: 635-642.
29. Park SW, Lee CH and Shin DH (2006). Effects of SA1, a herbal formulation, on sexual behavior and penile erection. Biol. Pharm. Bull., 29: 1383-1386.
30. Pribitkin EA (2005). Herbal Medicine and Surgery. Seminars in Integrative Medicine, 3: 17-23.
31. Rajendrin V, Joseph T and David J (1996). Plant drugs. Indian. Drugs, 33: 465.
32. Rodriguez-Fragoso L, Reyes-Esparza J, Burchiel SW, Herrera-Ruiz D and Torres E (2008). Risks and benefits of commonly used herbal medicines in Mexico. Toxicol. Appl. Pharmacol., 227(1): 125-135.
33. Rowland DL and Tai W (2003). A review of plant-derived and herbal approaches to the treatment of sexual dysfunctions. J. Sex Marital Ther., 29: 185-205.
34. Shappira Z (1987). Preliminary studies on the potential of some indigenous medicinal plants to regulate reproduction in white rats. Israel Journal of Botany Basic and Applied Plant Sciences, 36(4): 212.
35. Shukla YN, Srivastava A, Kumar S and Kumar S (1999). Phytotoxic and antimicrobial constituents of Argyreia speciosa and Oenothera biennis. J. Ethnopharmacol., 67: 241-245.
36. Teng L, Shaw D and Barnes J (2008). Practice of traditional Chinese herbal medicine shops in central London. Phytochemistry Letters, 1: 94-98.
37. Visavadiya NP and Narasimhacharya AVRL (2007). Hypocholesteremic and antioxidant effects of Withania somnifera (Dunal) in hypercholesteremic rats. Phytomedicine, 14: 136-142.
38. Wang ZG and Ren J (2002). Current status and future direction of Chinese herbal Medicine. TRENDS in Pharmacological Sciences, 23: 347-348.
39. Wong WY, Thomas CMG, Merkus JMWM (2000). Male factors subfertility: Possible route causes and the impact of nutritional factors. Fertil. Steril., 73: 435-442.