PNET/Ewing tumours: Current treatments and future perspectives;Tumeurs PNET/Ewing: Prise en charge actuelle et perspectives

Bulletin du Cancer

Volumn 97, Issue 6, 2010, Pages 707-713

  Marec Berard P ^a   Chotel, F ^b   Claude, L ^c  

^a IHOP   (France)

^b HOSPICES CIVILS DE LYON   (France)

^c CENTRE LÉON BÉRARD   (France)

Author keywords

Ewing's sarcoma; PNET; Teenager; Therapeutic; Young adult

Indexed keywords

CYCLOPHOSPHAMIDE; DACTINOMYCIN; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; GEMCITABINE; IFOSFAMIDE; RAPAMYCIN; TEMOZOLOMIDE; TOPOTECAN; TRABECTEDIN; VINCRISTINE; ZOLEDRONIC ACID;

CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; DRUG POTENTIATION; EWING SARCOMA; GROUPS BY AGE; HUMAN; IMAGING SYSTEM; INCIDENCE; INTENSITY MODULATED RADIATION THERAPY; METASTASIS; PROGNOSIS; REVIEW; SYSTEMIC THERAPY;

EID: 77953894142     PISSN: 00074551     EISSN: 17696917     Source Type: Journal    
DOI: 10.1684/bdc.2010.1120     Document Type: Review

References (42)

1. Delattre O, Zucman J, Melot T, Garau XS, Zucker JM, Lenoir GM, et al. The Ewing family of tumours - a subgroup of small-round-cell tumours defined by specific chimeric transcripts. N Engl J Med 1994; 331: 294-9.
2. Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 1992; 359: 162-5.
3. Turc-Carel CS. Contribution of cytogenetics to the diagnosis of Ewing's sarcoma and small round cell tumours. Bull Cancer 1991; 78: 77-84.
4. Riggi N, Suvà ML, Suvà D, Cironi L, Provero P, Tercier S, et al. EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells. Cancer Res 2008; 68: 2176-85.
5. Esiashvili N, Goodman M, Marcus Jr RB. Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: surveillance epidemiology and end results data. J Pediatr Hematol Oncol 2008; 30: 425-30.
6. Ahmad R, Mayol BR, Davis M, Rougraff BT. Extraskeletal Ewing's sarcoma. Cancer 1999; 85: 725-31.
7. Rud NP, Reiman HM, Pritchard DJ, Frassica FJ, Smithson WA. Extraosseous Ewing's sarcoma. A study of 42 cases. Cancer 1989; 64: 1548-53.
8. Patricio MB, Vilhena M, Neves M, Raposo S, Catita J, De Sousa V, et al. Ewing's sarcoma in children: twenty-five years of experience at the Instituto Portugês de Oncologia de Francisco Gentil (IPOFG). J Surg Oncol 1991; 47: 37-40.
9. Burgert Jr EO, Nesbit ME, Garnsey LA, Gehan EA, Herrmann J, Vietti TJ, et al. Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the First Intergroup study. J Clin Oncol 1990; 8: 1664-74.
10. Craft A. "Ewing's sarcoma". In : Pinkerton R, Philip T, Fervers B (eds). Evidence-based Paediatric Oncology. BMJ books, 2002.
11. Pinkerton CR, Bataillard A, Guillo S, Oberlin O, Fervers B, Philip T, et al. Treatment strategies for metastatic Ewing's sarcoma. Eur J Cancer 2001; 37: 1338-44. (Pubitemid 32588743)
12. Oberlin O, Rey A, Desfachelles AS, Philip T, Plantaz D, Schmitt C, et al. Impact of high-dose busulfan plus melphalan as consolidation in metastatic Ewing tumours: a study by the Société française des cancers de l'enfant. J Clin Oncol 2006; 24: 3997-4002. (Pubitemid 46630750)
13. Schleiermacher G, Peter M, Oberlin O, Philip T, Rubie H, Mechinaud F, et al. Increased risk of systemic relapses associated with bone marrow micrometastasis and circulating tumour cells in localized Ewing tumour. J Clin Oncol 2003; 21: 85-91.
14. Vermeulen J, Ballet S, Oberlin O, Peter M, Pierron G, Longavenne E, et al. Incidence and prognostic value of tumour cells detected by RT-PCR in peripheral blood stem cell collections from patients with Ewing tumour. Br J Cancer 2006; 95: 1326-33 [Epub 2006]. (Pubitemid 44760081)
15. Zoubek A, Dockhorn-Dworniczak B, Delattre O, Christiansen H, Niggli F, Gatterer-Menz I, et al. Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumour patients? J Clin Oncol 1996; 14: 1245-51.
16. de Alava E, Kawai A, Healey JH, Fligman I, Meyers PA, Huvos AG, et al. EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma. J Clin Oncol 1998; 16: 1248-55 (Erratum in: J Clin Oncol 1998 ; 16 : 2895). (Pubitemid 28175736)
17. Indelicato DJ, Keole SR, Shahlaee AH, Shi W, Morris CG, Gibbs Jr CP, et al. Long-term clinical and functional outcomes after treatment for localized Ewing's tumour of the lower extremity. Int J Radiat Oncol Biol Phys 2008; 70: 501-9.
18. Carrie C, Mascard E, Gomez F, Habrand JL, Alapetite C, Oberlin O, et al. Nonmetastatic pelvic Ewing sarcoma: report of the French society of pediatric oncology. Med Pediatr Oncol 1999; 33: 444-9.
19. Carrie C, Helfre S, Bouffet E, Brunat-Mentigny M. Radiotherapy and Ewing tumour in children. Bull Cancer 1995; 82: 527-30.
20. Bacci G, Ferrari S, Longhi A, Versari M, Forni C, Donati D, et al. Local and systemic control in Ewing's sarcoma of the femur treated with chemotherapy, and locally by radiotherapy and/or surgery. J Bone Joint Surg Br 2003; 85: 107-14. (Pubitemid 36193053)
21. Yock TI, Krailo M, Fryer CJ, Donaldson SS, Miser JS, Chen Z, et al. Local control in pelvic Ewing sarcoma: analysis from INT-0091 - a report from the Children's Oncology Group. J Clin Oncol 2006; 24: 4947.
22. Schuck A, Ahrens S, Paulussen M, Kuhlen M, Könemann S, Rübe C, et al. Local therapy in localized Ewing tumours: results of 1,058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials. Int J Radiat Oncol Biol Phys 2003; 55: 168-77. (Pubitemid 36020356)
23. Donaldson SS. Ewing sarcoma: radiation dose and target volume. Pediatr Blood Cancer 2004; 42: 471-6.
24. Claude L. Pediatric Radiation Oncology Society Congress, Barcelona, 27-29 June 2007.
25. Paulussen M, Ahrens S, Burdach S, Craft A, Dockhorn-Dworniczak B, Dunst J, et al. Primary metastatic (stage IV) Ewing tumour: survival analysis of 171 patients from the EICESS studies. European Intergroup Cooperative Ewing Sarcoma Studies. Ann Oncol 1998; 9: 275-81. (Pubitemid 28186797)
26. Grier HE, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumour of bone. N Engl J Med 2003; 348: 694-701.
27. Meyer WH, Kun L, Marina N, Roberson P, Parham D, Rao B, et al. Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone. J Clin Oncol 1992; 10: 1737-42.
28. Granowetter L, Womer R, Devidas M, Krailo M, Wang C, Bernstein M, et al. Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumours: a Children's Oncology Group Study. J Clin Oncol 2009; 27: 2536-41.
29. Cornbleet MA, Corringham RE, Prentice HG, Boesen EM, McElwain TJ. Treatment of Ewing's sarcoma with high-dose melphalan and autologous bone marrow transplantation. Cancer Treat Rep 1981; 65: 241-4.
30. Hartmann O, Benhamou E, Beaujean F, Pico JL, Kalifa C, Patte C, et al. High-dose busulfan and cyclophosphamide with autologous bone marrow transplantation support in advanced malignancies in children: a phase II study. J Clin Oncol 1986; 4: 1804-10.
31. Burdach S, van Kaick B, Laws HJ, Ahrens S, Haase R, Körholz D, et al. Allogeneic and autologous stem-cell transplantation in advanced Ewing tumours. An update after long-term follow-up from two centers of the European Intergroup study EICESS. Stem-Cell Transplant Programs at Düsseldorf University Medical Center, Germany and St-Anna Kinderspital, Vienna, Austria. Ann Oncol 2000; 11: 1451-62.
32. Drabko K, Zawitkowska-Klaczynska J, Wojcik B, Choma M, Zaucha-Prazmo A, Kowalczyk J, et al. Megachemotherapy followed by autologous stem cell transplantation in children with Ewing's sarcoma. Pediatr Transplant 2005; 9: 618-21. (Pubitemid 41413501)
33. Al-Faris N, Al Harbi T, Goia C, Pappo A, Doyle J, Gassas A. Does consolidation with autologous stem cell transplantation improve the outcome of children with metastatic or relapsed Ewing sarcoma? Pediatr Blood Cancer 2007; 49: 190-5.
34. Saylors 3rd RL, Stewart CF, Zamboni WC, Wall DA, Bell B, Stine KC, et al. Phase I study of topotecan in combination with cyclophosphamide in pediatric patients with malignant solid tumours: a Pediatric Oncology Group study. J Clin Oncol 1998; 16: 945-52.
35. Bernstein ML, Devidas M, Lafreniere D, Souid AK, Meyers PA, Gebhardt M, et al. Intensive therapy with growth factor support for patients with Ewing tumour metastatic at diagnosis: Pediatric Oncology Group/Children's Cancer Group phase II study 9457 - a report from the Children's Oncology Group. J Clin Oncol 2006; 24: 152-9.
36. Hunold A, Weddeling N, Paulussen M, Ranft A, Liebscher C, Jürgens H. Topotecan and cyclophosphamide in patients with refractory or relapsed Ewing tumours. Pediatr Blood Cancer 2006; 47: 795-800. (Pubitemid 44476756)
37. Wagner LM, McAllister N, Goldsby RE, Rausen AR, McNall-Knapp RY, McCarville MB, et al. Temozolomide and intravenous irinotecan for treatment of advanced Ewing sarcoma. Pediatr Blood Cancer 2007; 48: 132.
38. Cassier PA, Dufresne A, El Sayadi H, Pissaloux D, Alberti L, Decouvelaere AV, et al. Targeted therapy of sarcomas. Bull Cancer 2008; 95: 963-74.
39. Mateo-Lozano S, Tirado OM, Notario V. Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation. Oncogene 2003; 22: 9282-7.
40. Myatt SS, Redfern CP, Burchill SA. p38MAPK-Dependent sensitivity of Ewing's sarcoma family of tumours to fenretinide-induced cell death. Clin Cancer Res 2005; 11: 3136-48.
41. Bleyer A. Older adolescents with cancer in North America deficits in outcome and research. Pediatr Clin North Am 2002; 49: 1027-42.
42. Bleyer A, Montello M, Budd T, Saxman S. National survival trends of young adults with sarcoma: lack of progress is associated with lack of clinical trial participation. Cancer 2005; 103: 1891.