Mutation of archaeal isopentenyl phosphate kinase highlights mechanism and guides phosphorylation of additional isoprenoid monophosphates

ACS Chemical Biology

Volumn 5, Issue 6, 2010, Pages 589-601

  Dellas, Nikki ^a,b   Noel, Joseph P ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID KINASE; FUNCTIONAL GROUP; GLYCOPROTEIN; HISTIDINE; ISOPENTENYL DIPHOSPHATE; ISOPENTENYL PHOSPHATE KINASE; ISOPRENOID PHOSPHATE; MAGNESIUM ION; MEVALONIC ACID; MUTANT PROTEIN; PHOSPHONIC ACID DERIVATIVE; PHOSPHOTRANSFERASE; STEROID; UNCLASSIFIED DRUG; VITAMIN; HEMITERPENE; ISOPENTENYL MONOPHOSPHATE KINASE; ORGANOPHOSPHORUS COMPOUND; PROTEIN BINDING; PROTEIN KINASE;

ARCHAEBACTERIUM; ARTICLE; BIOSYNTHESIS; CARBOHYDRATE TRANSPORT; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME MECHANISM; GLYCOPROTEIN SYNTHESIS; HYDROGEN BOND; IN VITRO STUDY; MEMBRANE STABILIZATION; METABOLISM; METHANOCOCCUS JANNASCHII; MOLECULAR STABILITY; MUTATION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN FAMILY; PROTON TRANSPORT; STEADY STATE; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; METHANOCOCCALES; MOLECULAR GENETICS; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ARCHAEA; METHANOCALDOCOCCUS JANNASCHII;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HEMITERPENES; METHANOCOCCALES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHORYLATION; POLYISOPRENYL PHOSPHATES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN KINASES;

EID: 77953851215     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb1000313     Document Type: Article

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