Implication of gender differences in heroin-assisted treatment: Results from the German randomized controlled trial

American Journal on Addictions

Volumn 19, Issue 4, 2010, Pages 312-318

  Eiroá Orosa, Francisco José ^a,b   Verthein, Uwe ^a   Kuhn, Silke ^a   Lindemann, Christina ^a,c   Karow, Anne ^a   Haasen, Christian ^a   Reimer, Jens ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c ROBERT KOCH INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIAMORPHINE; METHADONE; NARCOTIC AGENT;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HEROIN DEPENDENCE; HUMAN; MALE; MENTAL STRESS; MULTICENTER STUDY; PROGNOSIS; PROSTITUTION; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; GERMANY; MEDICATION COMPLIANCE; OPIOID-RELATED DISORDERS; SEXUAL DEVELOPMENT; STATISTICS AND NUMERICAL DATA;

ADULT; FEMALE; GERMANY; HEROIN; HUMANS; MALE; MEDICATION ADHERENCE; METHADONE; NARCOTICS; OPIOID-RELATED DISORDERS; PROSTITUTION; SEX CHARACTERISTICS;

EID: 77953846221     PISSN: 10550496     EISSN: 15210391     Source Type: Journal    
DOI: 10.1111/j.1521-0391.2010.00049.x     Document Type: Article

References (45)

1. European Monitoring Centre for Drugs and Drug Addiction. Annual report 2006. Selected issue 2. A gender perspective on drug use and responding to drug problems.
2. Departament of Health and Human Services; Substance Abuse and Mental Health Services Administration. Results from the 2007 National Survey on Drug Use and Health: National Findings.
3. Cormier RA, Dell CA, Poole N. Women and substance abuse problems. BMC Womens Health. 2004 4 (Suppl. 1 S8.
4. Kokkevi A, Fotiou A, Arapaki A, Richardson C. Prevalence, patterns, and correlates of tranquilizer and sedative use among European adolescents. J Adolesc Health. 2008 43 : 584 592.
5. Bell R, Havlicek PL, Roncek DW. Sex differences in the use of alcohol and tranquilizers: Testing a role convergence hypothesis. Am J Drug Alcohol Abuse. 1984 10 : 551 561.
6. Chatham LR, Hiller ML, Rowan-Szal GA, Joe GW, Simpson DD. Gender differences at admission and follow-up in a sample of methadone maintenance clients. Subst Use Misuse. 1999 34 : 1137 1165.
7. Stewart D, Gossop M, Marsden J, Kidd T, Treacy S. Similarities in outcomes for men and women after drug misuse treatment: Results from the National Treatment Outcome Research Study (NTORS). Drug Alcohol Rev. 2003 22 : 35 41.
8. Puigdollers E, Domingo-Salvany A, Brugal MT, et al. Characteristics of heroin addicts entering methadone maintenance treatment: Quality of life and gender. Subst Use Misuse. 2004 39 : 1353 1368.
9. Dwyer R, Richardson D, Ross MW, Wodak A, Miller ME, Gold J. A comparison of HIV risk between women and men who inject drugs. AIDS Educ Prev. 1994 6 : 379 389.
10. Freeman R, Rodriguez G, French J. A comparison of male and female intravenous drug users' risk behaviors for HIV infection. Am J Drug Alcohol Abuse. 1994 20 : 129 157.
11. Booth R. Gender differences in high-risk sex behaviors among heterosexual drug injectors and crack smokers. Am J Drug Alcohol Abuse. 1995 21 : 419 432.
12. Bennett G, Velleman R, Barter G, Bradbury C. Gender differences in sharing injecting equipment by drug users in England. AIDS Care. 2000 12 : 77 87.
13. Sherman S, Latkin C, Gielen A. Social factors related to syringe sharing among injecting partners: A focus on gender. Subst Use Misuse. 2001 36 : 2113 2136.
14. Breen C, Roxburgh A, Degenhardt L. Gender differences among regular injecting drug users in Sydney, Australia, 1996-2003. Drug Alcohol Rev. 2005 24 : 353 358.
15. Patrick DM, Tyndall MW, Cornelisse PG, et al. Incidence of hepatitis C virus infection among injection drug users during an outbreak of HIV. CMAJ. 2001 165 : 889 895.
16. Cedar Project Partnership, Mehrabadi A, Paterson K, et al. Gender differences in HIV and hepatitis C related vulnerabilities among aboriginal young people who use street drugs in two Canadian cities. Women Health. 2008 48 : 235 260.
17. Gombas W, Fischer G, Jagsch R, et al. Prevalence and distribution of hepatitis C subtypes in patients with opioid dependence. Eur Addict Res. 2000 6 : 198 204.
18. Miller CL, Kerr T, Strathdee SA, Li K, Wood E. Factors associated with premature mortality among young injection drug users in Vancouver. Harm Reduct J. 2007 4 : 1 7.
19. Greenfield SF, Brooks AJ, Gordon SM, et al. Substance abuse treatment entry, retention, and outcome in women: A review of the literature. Drug Alcohol Depend. 2007 86 : 1 21.
20. Grella CE, Greenwell L. Substance abuse treatment for women: Changes in the settings where women received treatment and types of services provided, 1987-1998. J Behav Health Serv Res. 2004 31 : 367 383.
21. Grella CE, Scott CK, Foss MA, Joshi V, Hser Y-I. Gender differences in drug treatment outcomes among participants in the Chicago Target Cities Study. Eval Program Plann. 2003 26 : 297 310. (Pubitemid 36978469)
22. Grella CE, Stein JA, Greenwell L. Associations among childhood trauma, adolescent problem behaviors, and adverse adult outcomes in substance-abusing women offenders. Psychol Addict Behav. 2005 19 : 43 53.
23. Peles E, Schreiber S, Naumovsky Y, Adelson M. Depression in methadone maintenance treatment patients: Rate and risk factors. J Affect Disord. 2007 99 : 213 220.
24. Schiff M, Levit S, Moreno RC. Retention and illicit drug use among methadone patients in Israel: A gender comparison. Addict Behav. 2007 32 : 2108 2119. Epub 2007 Jan 23.
25. Brady TM, Ashley OS. Women in substance abuse treatment: Results from the alcohol and drug services study (ADSS) 2005. Available at : http://www.drugabusestatistics.samhsa.gov/womenTX/womenTX.htm. Accessed September 2, 2009.
26. Acharyya S, Zhang H. Assessing sex differences on treatment effectiveness from the Drug Abuse Treatment Outcome Study (DATOS). Am J Drug Alcohol Abuse. 2003 29 : 415 444.
27. Alterman AI, Randall M, McLellan AT. Comparison of outcomes by gender and for fee-for-service versus managed care: A study of nine community programs. J Subst Abuse Treat. 2000 19 : 127 134.
28. Chatham LR, Hiller ML, Rowan-Szal GA, Joe GW, Simpson DD. Gender differences at admission and follow-up in a sample of methadone maintenance clients. Subst Use Misuse. 1999 34 : 1137 1165.
29. Peles E, Adelson M. Gender differences and pregnant women in a methadone maintenance treatment (MMT) clinic. J Addict Dis. 2006 25 : 39 45.
30. Oggins J, Guydish J, Delucchi K. Gender differences in income after substance abuse treatment. J Subst Abuse Treat. 2001 20 : 215 224.
31. Comfort M, Sockloff A, Loverro J, Kaltenbach K. Multiple predictors of substance-abusing women's treatment and life outcomes: A prospective longitudinal study. Addict Behav. 2003 28 : 199 224.
32. McMahon TJ, Winkel JD, Suchman NE, Luthar SS. Drug dependence, parenting responsibilities, and treatment history: Why doesn't mom go for help Drug Alcohol Depend. 2002 65 : 105 114.
33. Haasen C, Van Den Brink W. Innovations in agonist maintenance treatment of opioid-dependent patients. Curr Opin Psychiatry. 2006 19 : 631 636.
34. Rehm J, Gschwend P, Steffen T, Gutzwiller F, Dobler-Mikola A, Uchtenhagen A. Feasibility, safety, and efficacy of injectable heroin prescription for refractory opioid addicts: A follow-up study. Lancet. 2001 358 : 1417 1420.
35. Van Den Brink W, Hendriks VM, Blanken P, Koeter MWJ, van Zwieten BJ, van Ree JM. Medical prescription of heroin to treatment resistant heroin addicts: Two randomised controlled trials. BMJ. 2003 327 : 310.
36. March JC, Oviedo-Joekes E, Perea-Milla E, Carrasco F. Controlled trial of prescribed heroin in the treatment of opioid addiction. J Subst Abuse Treat. 2006 31 : 203 211.
37. Haasen C, Verthein U, Degkwitz P, Berger J, Krausz M, Naber D. Heroin-assisted treatment for opioid dependence: Randomised controlled trial. Br J Psychiatry. 2007 191 : 55 62.
38. Oviedo-Joekes E, Brissette S, Marsh DC, et al. Diacetylmorphine versus methadone for the treatment of opioid addiction. N Engl J Med. 2009 361 : 777 786.
39. Ribeaud D. Long-term impacts of the Swiss heroin prescription trials on crime of treated heroin users. J Drug Issues. 2004 34 : 163 194.
40. Haasen C, Eiroa-Orosa FJ, Verthein U, et al. Effects of heroin-assisted treatment on alcohol consumption: Findings of the German randomized controlled trial. Alcohol. 2009 43 : 259 264.
41. Derogatis LR. SCL-90-R: Administration, Scoring and Procedures Manual.
42. Darke S, Ward J, Zador D, Swift G. A scale for estimating the health status of opioid users. Addiction. 1991 86 : 1317 1322.
43. Kokkevi A, Hartgers C. EuropASI: European adaptation of a multidimensional assessment instrument for drug and alcohol dependence. Eur Addiction Res. 1995 1 : 208 210.
44. Gsellhofer B, Küfner H, Vogt M, Weiler D, editors. Nach der 5. Auflage der amerikanischen Version von McLellan und der Europäischen Version des ASI Baltmannsweiler 1999.
45. McLellan AT, Kushner H, Metzger D, et al. The fifth edition of the addiction severity index. J Subst Abuse Treat. 1992 9 : 199 213.