Lipid lowering activity of anthocephalus indicus root in hyperlipidemic rats

Evidence-based Complementary and Alternative Medicine

Volumn 7, Issue 3, 2010, Pages 317-322

  Kumar, Vishnu ^a   Khan, Mohammad Mubin ^b   Khanna, Ashok Kumar ^c   Singh, Ranjana ^c   Singh, Sushma ^c   Chander, Ramesh ^c   Mahdi, Farzana ^a   Mahdi, Abbas Ali ^c   Saxena, Jitendra Kumar ^b   Singh, Raj Kumar ^c  

^a Eras Lucknow Medical College and Hospital   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

^c KING GEORGE'S MEDICAL UNIVERSITY   (India)

Author keywords

Anthocephalus indicus; hypolipidemic agent; oxygen free radical scavengers; plant antioxidant; Rubiaceae; triton model of hyperlipidemia

Indexed keywords

ANTHOCEPHALUS INDICUS EXTRACT; CHOLESTEROL; GEMFIBROZIL; HEPARIN; HYDROXYL RADICAL; PHOSPHOLIPID; PLANT EXTRACT; SUPEROXIDE; TRIACYLGLYCEROL; TYLOXAPOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHOCEPHALUS INDICUS; ANTILIPIDEMIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; ENZYME ACTIVITY; FEEDING; HYPERLIPIDEMIA; IN VITRO STUDY; LIPOLYSIS; MALE; MEDICINAL PLANT; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PLANT ROOT; PRIORITY JOURNAL; RAT; RUBIACEAE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 77953835623     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1093/ecam/nen001     Document Type: Article

References (32)

1. Zalba G, San JG, Moreno MU, Fortuno A, Beaumont FJ, Diez J. Oxidative stress in arterial hypertension. Role of NADPH oxidase. Hypertension 2001;38:1395-1399
2. Rehman S, Mahdi AA, Hasan M. Trace metal induced lipid peroxidation in biological system. SFRR (India) Bull 2003;2:12-18.
3. Parthasarthy S, Steinberg D, Seitztum JL. The role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis. Ann Rev Med 1992;43:219-225
4. Chattopadhyaya R, Pathak D, Jindal DP. Antihyperlipidemic agents. A review. Indian drugs 1996;33:85-97.
5. Dahanukar SA, Kulkarni RA, Rege NN. Pharmacology of medicinal plants and natural products. Indian J Pharmacol 2000;32:S81-S118.
6. Sircar NN. Pharmacological basis of Ayurvedic therapy. In: Atal CK, Kapoor BM (eds). Cultivation and Utilization of Medicinal Plants. New Delhi, India: Publication and Iinformation Directorate, CSIR; 1992, 507-518
7. Slkar IV, Kakkar KK, Chakre OJ. Glossary of Indian Medicinal Plants With Active Principles. New Delhi: CSIR, 1992, 75.
8. Umachigi SP, Kumar GS, Jayaveera KN, Kishore Kumar DV, Ashok Kumar CK, Dhanapal R. Antimicrobial, wound healing and antioxidant activities of Anthocephalus Cadamba. Afr J Trad Comp Alt Med 2007;4:481-487
9. Sianne Schwikkard, FanieR van Heerden. Antimalarial activity of plant metabolite. Nat Prod Rep 2002;19:675-692
10. Kapil A, Kouli B, Suri OP. Antihepatotoxic effects of chlorogenic acid from Anthocephalus Cadamba. Phytother Res 1995;9:189-193
11. Paranjpe P. Indian medicinal plants, forgotten healeres. In: Paranjpe P (ed). A Guide to Ayurvedic Herbal Medicine. Delhi, India: Chaukhamba Sanskrit Pratishthan, 2001, 112-113
12. Shaua NP, Koike K, Jia Z, Banerjee S, Mandal NB, Nikaido T. Triterpene glycoides from bark of Anthocephalus Cadabma. J. Chem Res 2000;1:22-23
13. Schurr PE, Schultz JR, Parkinson TM. Triton induced hyperlipidemia in rats as an animal model for screening of hypoliperimic drugs. Lipids 1972;7:68-74.
14. Nityanand S, Kapoor NK. Cholestrol lowering activity of the various fractions of the guggul. Indian J Exp Biol 1973; 11:395-396
15. Schweitzer M, Tessier D, Vlahos WD, Leiter L, Collet JP, McQueen MJ, et al. A comparison of pravastatin and gemfibrozil in the treatment of dyslipoproteinemia in patients with non-insulindependent diabetes mellitus. Atherosclerosis 2002;162:201-210
16. Rizvi F, Puri A, Bhatia G, Khanna AK, Wulff EM, Rastogi AK, et al. Antidyslipidmic action of fenofibret in dyslipidemic diebetic hamstermodel. Biochem Biophys Res Commun 2003;305:215-222
17. Bindoli A, Valente M, Cavallim L. Inhibition of xanthine oxidase and xanthine dehydrogenase activity. Pharmacol Res Commun 1985;17:831-839
18. McCord JM, Fridovich I. Superoxide dismutase, an enzyme function for erythrocuprin (hemocuprin). J Biol Chem 1969;244:6049-6055
19. Richmond R, Halliwell R, Chauhan J, Darbre A. Superoxide dependent formation of hydroxyl radicals: detection of hydroxyl radicals by hydroxylation of aromatic compounds. Anal Biochem 1981;118:320-335
20. Halliwell B, Gutteridge JMC, Arouma OI. The deoxyribose method: a simple test tube assay for determination of rate constants for reaction of OH- radicals. Anal Biochem 1987;165:215-219
21. Woodson RF. Statistical Methods for the Analysis of Biochemical Data. Chichester: Wiley, 1987, 315.
22. Mabuchmet H, Sakai T, Sakai Y, Yoshimura A, Watanbe A, Wakasugi T, et al. Reduction of serum cholesterol in heterozygous of familial hypercholesterolemia additive effects of compactin and cholestyramine. New Engl J Med 1983;308:609-613
23. Casdorph HR. Treatment of hypercholesteremia with cholestyramine, a bile acid sequestering resin. Vasc Dis 1976;4:305-308
24. Frick MH, Nikkila EA. Helsinki Heart Study: primary prevention trail with gemfibrozil in middle aged men with dyslipidemia. New Engl J Med 1987;317:1237-1245
25. Emami SA, Asili J, Mohagheghi Z, Hassanzadeh MK. Antioxidant activity of leaves and fruits of Iranian conifers. Evid Based Complement Alternat Med 2007;4:313-319
26. Khanna AK, Chander R, Kapoor NK, Dhawan BN. Hypolipidemic activity of picroliv in albino rats. Phytother Res 1994;8:403-407
27. Khanna AK, Rizvi F, Chander R. Lipid lowering activity of Phyllanthus niruri in hyperlipidemic rats. J Ethnopharmacol 2002;82:19-22.
28. Brown RT, Fraser SB, Banerji J. Heart wood of cadamba contains glucoalkaloids of isodihydrocadambine. Tetrahedron Lett 1974;29:3335.
29. Brown RT, Chapple CL. Anthocephalus alkaoids: 3a- dihydrocadambine and 3b- isodihydrocadambine. Tetrahedron Lett 1976;31:2723-2724
30. Sahu NP, Mahto SB, Banerji N, Chakravarti RN. Cadamibic acid. A new triterpenic acid from Anthocephalus cadamb. Indian J Chem 1974;17:284-286
31. Chandra O, Gupta D. A complex polysaccharide from the seeds of Anthocephalus indicus. Carbohydr Res 1980;83:85-92.
32. Toyota M, Asakawa Y. Sesquiterpenoids and cyclic bis (bibenzyls) from the Pakistani Liverwort Plagiochasma appendiculatum. J Hattori Bot Lab 1999;86:161-167