MR findings of the brain in children and adolescents with portal hypertension and the relationship with blood manganese levels

Neuropediatrics

Volumn 41, Issue 1, 2010, Pages 12-17

  Pinto, R B ^a   Froehlich P E ^b   Pitrez, E H ^c   Bragatti, J A ^a   Becker, J ^d   Cornely, A F H ^b   Schneider, A C R ^b   Da Silveira, T R ^c  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c Radiology Service Hospital de Cl í Nicas de Porto Alegre   (Brazil)

^d PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

atomic absorption spectrophotometry; brain magnetic resonance imaging; children; liver disease; manganese

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AMMONIA; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GAMMA GLUTAMYLTRANSFERASE; MANGANESE; SERUM ALBUMIN;

ADOLESCENT; AMMONIA BLOOD LEVEL; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BASAL GANGLION; BLOOD CELL COUNT; BLOOD SAMPLING; CALIBRATION; CASE CONTROL STUDY; CHILD; CHOLESTASIS; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTROENCEPHALOGRAM; ENDOSCOPY; ENZYME BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; LABORATORY TEST; LIVER CIRRHOSIS; LIVER FUNCTION TEST; NEUROIMAGING; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTIAL THROMBOPLASTIN TIME; PORTAL HYPERTENSION; PRIORITY JOURNAL; PROTHROMBIN TIME; THROMBOCYTE COUNT; TRACE METAL BLOOD LEVEL; BLOOD; BRAIN; COMPLICATION; FEMALE; HYPERTENSION, PORTAL; IMAGE PROCESSING; LIVER DISEASE; MALE; PATHOLOGY; PROCEDURES; RETROSPECTIVE STUDY; YOUNG ADULT;

ADOLESCENT; AMMONIA; BRAIN; CASE-CONTROL STUDIES; CHILD; FEMALE; HUMANS; HYPERTENSION, PORTAL; IMAGE PROCESSING, COMPUTER-ASSISTED; LIVER DISEASES; MAGNETIC RESONANCE IMAGING; MALE; MANGANESE; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 77953826435     PISSN: 0174304X     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0030-1254157     Document Type: Article

References (20)

1. Ballauff A, Engelbrecht V, Voit T. Hyperintense lesions of the globus pallidus on MRI in children with chronic liver disease. Eur J Pediatr 1994 153 802-806
2. Devenyi AG, Barron TF, Mamourian AC. Dystonia, hyperintense basal ganglia, and high whole blood manganese levels in Alagille's syndrome. Gastroenterology 1994 106 1068-1071
3. Genovese E, Maghnie M, Maggiore G, et al. MR imaging of CNS involvement in children affected by chronic liver disease. Am J Neuroradiol 2000 21 845-851
4. Ikeda S, Sera Y, Yoshida M, et al. Manganese deposits in patients with biliary atresia after hepatic porto-enterostomy. J Pediatr Surg 2000 35 450-453 (Pubitemid 30131609)
5. Inoue E, Hori S, Narumi Y, et al. Portal-systemic encephalopathy: presence of basal ganglia lesions with high signal intensity on MR images. Radiology 1991 179 551-555
6. Klos KJ, Ahlskog E, Josephs KA, et al. Neurologic spectrum of chronic liver failure and basal ganglia T1 hyperintensity on magnetic resonance imaging. Probable manganese neurotoxicity. Arch Neurol 2005 62 1385-1390
7. Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet 1995 346 270-274
8. Krieger S, Jauss M, Jansen O, et al. MRI findings in chronic encephalopathy depend on portosystemic shunt: results of a controlled prospective clinical findings. J Hepatol 1997 27 121-126
9. Mínguez B, García-Pagán JC, Bosch J, et al. Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy. Hepatology 2006 43 707-714
10. Mizoguchi N, Nishimura Y, Ono H, et al. Manganese elevations in blood of children with congenital portosystemic shunts. Eur J Pediatr 2001 160 247-250
11. Nolte W, Wiltfang J, Schindler CG, et al. Bright basal ganglia in T 1-weighted magnetic resonance images are frequent in patients with portal vein thrombosis without liver cirrhosis and not suggestive of hepatic encephalopathy. J Hepatol 1998 29 443-449
12. Pugh RN, Murray-Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding varices. Br J Surg 1973 60 646-649
13. Pujol A, Pujol F, Graus F, et al. Hyperintense globus pallidus on T 1-weighted MRI in cirrhotic patients is associated with severity of liver disease. Neurology 1993 43 65-69
14. Rose C, Butterworth RF, Zayed J, et al. Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction. Gastroenterology 1999 117 640-644
15. Shah NJ, Neeb H, Zaitsev M, et al. Quantitative T1 mapping of hepatic encephalopathy using magnetic resonance imaging. Hepatology 2003 38 1219-1226
16. Skranes J, Evensen KI, Lohaugen GC, et al. Abnormal cerebral MRI findings and neuroimpairments in very low birth weight (VLBW) adolescents. Eur J Paediatr Neurol 2008 12 273-283
17. Spahr L, Butterworth RF, Fontaine S, et al. Increased blood manganese in cirrhotic patients: relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms. Hepatology 1996 24 1116-1120
18. Uchino A, Noguchi T, Nomiyama K, et al. Manganese accumulation in the brain: MR imaging. Neuroradiology 2007 49 715-720
19. Verbruggen KT, Meiners LC, Sijens PE, et al. Magnetic resonance imaging and proton magnetic resonance spectroscopy of the brain in the diagnostic evaluation of development delay. Eur J Paediatr Neurol 2009 13 181-190
20. Yanai S, Minami T, Sonoda K, et al. Patent ductus venous associated with a hyperintense globus pallidum on T1-weighted magnetic resonance imaging and pulmonary hypertension. Eur J Pediatr 1995 154 526-529