Occult cytomegalovirus in vivarium-housed mice may influence transplant allograft acceptance

Transplant Immunology

Volumn 23, Issue 1-2, 2010, Pages 86-91

  Thomas, A C ^a   Forster, M R ^a   Bickerstaff, A A ^a   Zimmerman, P D ^a   Wing, B A ^a   Trgovcich, J ^a   Bergdall, V K ^a   Klenerman, P ^b   Cook, C H ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Antibody responses; Cardiac transplantation; CD8 T cell responses; Cytomegalovirus; Mice; Occult infection

Indexed keywords

VIRUS ANTIBODY; VIRUS DNA;

ALLOTRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DNA SEQUENCE; FEMALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEROLOGY; T LYMPHOCYTE; VIRUS TRANSMISSION; ANIMAL; ANIMAL HOUSING; BAGG ALBINO MOUSE; C57BL MOUSE; COMPLICATION; CYTOMEGALOVIRUS INFECTIONS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; MOLECULAR GENETICS; MUROMEGALOVIRUS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; STANDARDS;

ANIMALS; BASE SEQUENCE; CYTOMEGALOVIRUS INFECTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; HOUSING, ANIMAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUROMEGALOVIRUS; POLYMERASE CHAIN REACTION; TRANSPLANTATION, HOMOLOGOUS;

EID: 77953812127     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2010.03.005     Document Type: Article

References (31)

1. Orosz C.G., Wakely E., Sedmak D.D., Bergese S.D., VanBuskirk A.M. Prolonged murine cardiac allograft acceptance: characteristics of persistent active alloimmunity after treatment with gallium nitrate versus anti-CD4 monoclonal antibody. Transplantation 1997, 63:1109-1117.
2. Bickerstaff A., Orosz C. Evidence for a limited contribution of immune regulation to cardiac allograft acceptance. Hum Immunol 2002, 63:935-947.
3. Bickerstaff A.A., VanBuskirk A.M., Wakely E., Orosz C.G. Transforming growth factor-beta and interleukin-10 subvert alloreactive delayed type hypersensitivity in cardiac allograft acceptor mice. Transplantation 2000, 69:1517-1520.
4. Bickerstaff A.A., Xia D., Pelletier R.P., Orosz C.G. Mechanisms of graft acceptance: evidence that plasminogen activator controls donor-reactive delayed-type hypersensitivity responses in cardiac allograft acceptor mice. J Immunol 2000, 164:5132-5139.
5. Cook C.H., Bickerstaff A.A., Wang J.J., Zimmerman P.D., Forster M.R., Nadasdy T., et al. Disruption of murine cardiac allograft acceptance by latent cytomegalovirus. Am J Transplant 2009, 9:42-53.
6. Staras S.A.S., Dollard S.C., Radford K.W., Dana Flanders W., Pass R.F., Cannon M.J. Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. Clin Infect Dis 2006, 43:1143-1151.
7. Smith A.L., Singleton G.R., Hansen G.M., Shellam G. A serologic survey for viruses and Mycoplasma pulmonis among wild house mice (Mus domesticus) in southeastern Australia. J Wildl Dis 1993, 29:219-229.
8. Pritchett-Corning K.R., Cosentino J., Clifford C.B. Contemporary prevalence of infectious agents in laboratory mice and rats. Lab Anim 2009, 43:165-173.
9. Kurz S.K., Rapp M., Steffens H.P., Grzimek N.K., Schmalz S., Reddehase M.J. Focal transcriptional activity of murine cytomegalovirus during latency in the lungs. J Virol 1999, 73:482-494.
10. Cook C.H., Trgovcich J., Zimmerman P.D., Zhang Y., Sedmak D.D. Lipopolysaccharide, tumor necrosis factor alpha, or interleukin-1{beta} triggers reactivation of latent cytomegalovirus in immunocompetent mice. J. Virol. 2006, 80:9151-9158.
11. Cook C., Zhang X., McGuinness B., Lahm M., Sedmak D., Ferguson R. Intra-abdominal bacterial infection reactivates latent pulmonary cytomegalovirus in immunocompetent mice. J Infect Dis 2002, 185:1395-1400.
12. Del Val M., Volkmer H., Rothbard J.B., Jonjic S., Messerle M., Schickedanz J., et al. Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp 89. J. Virol. 1988, 62:3965-3972.
13. Holtappels R., Grzimek N.K.A., Simon C.O., Thomas D., Dreis D., Reddehase M.J. Processing and presentation of murine cytomegalovirus pORFm164-derived peptide in fibroblasts in the face of all viral immunosubversive early gene functions. J. Virol. 2002, 76:6044-6053.
14. Sierro S., Rothkopf R., Klenerman P. Evolution of diverse antiviral CD8+ T cell populations after murine cytomegalovirus infection. Eur J Immunol 2005, 35:1113-1123.
15. Altman J.D., Moss P.A.H., Goulder P.J.R., Barouch D.H., McHeyzer-Williams M.G., Bell J.I., et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 1996, 274:94-96.
16. Collins T., Pomeroy C., Jordan M.C. Detection of latent cytomegalovirus DNA in diverse organs of mice. J Infect Dis 1993, 168:725-729.
17. Ehlers B., Kuchler J., Yasmum N., Dural G., Voigt S., Schmidt-Chanasit J., et al. Identification of novel rodent herpesviruses, including the first gammaherpesvirus of Mus musculus. J. Virol. 2007, 81:8091-8100.
18. Smith L.M., McWhorter A.R., Masters L.L., Shellam G.R., Redwood A.J. Laboratory strains of murine cytomegalovirus are genetically similar to but phenotypically distinct from wild strains of virus. J. Virol. 2008, 82:6689-6696.
19. Gujar S.A., Michalak T.I. Primary occult hepadnavirus infection induces virus-specific T cell and aberrant cytokine responses in the absence of anti-viral antibody reactivity in the woodchuck model of hepatitis B. J. Virol. 2009, 83:3861-3876.
20. Karrer U., Sierro S., Wagner M., Oxenius A., Hengel H., Koszinowski U.H., et al. Memory inflation: continuous accumulation of antiviral CD8+ T cells over time. J Immunol 2003, 170:2022-2029.
21. Kotsimbos A.Thomas C., Sinickas V., Glare Eric M., Esmore Donald S., Snell Gregory I., Walters E.H., et al. Quantitative detection of human cytomegalovirus DNA in lung transplant recipients. Am. J. Respir. Crit. Care Med. 1997, 156:1241-1246.
22. Boeckh M., Huang M., Ferrenberg J., Stevens-Ayers T., Stensland L., Nichols W.G., et al. Optimization of quantitative detection of cytomegalovirus DNA in plasma by real-time PCR. J. Clin. Microbiol. 2004, 42:1142-1148.
23. Henson D., Smith R.D., Gehrke J. Non-fatal mouse cytomegalovirus hepatitis. Combined morphologic, virologic and immunologic observations. Am J Pathol 1966, 49:871-888.
24. Cook C.H., Zimmerman P., Zhang Y., Chen L., Wen J., Trgovcich J., et al. CD28/B7-mediated costimulation is critical for early control of murine cytomegalovirus infection. Viral Immunol 2009, 22:91-103.
25. Streblow D.N., Orloff S.L., Nelson J.A. Acceleration of allograft failure by cytomegalovirus. Curr Opin Immunol 2007, 19:577-582.
26. Carlquist J.F., Shelby J., Shao Y.L., Greenwood J.H., Hammond M.E., Anderson J.L. Accelerated rejection of murine cardiac allografts by murine cytomegalovirus-infected recipients. Lack of haplotype specificity. J Clin Invest 1993, 91:2602-2608.
27. Shao Y.L., Shelby J., Hisatake G., Kern E.R., Nelson E.W., Gay W.A. Accelerated cardiac allograft rejection in murine cytomegalovirus-infected C3H recipients. Transplant Proc 1991, 23:129-130.
28. Williams M.A., Onami T.M., Adams A.B., Durham M.M., Pearson T.C., Ahmed R., et al. Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen. J Immunol 2002, 169:5387-5391.
29. Williams M.A., Tan J.T., Adams A.B., Durham M.M., Shirasugi N., Whitmire J.K., et al. Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance. J Immunol 2001, 167:4987-4995.
30. Welsh R.M., Markees T.G., Woda B.A., Daniels K.A., Brehm M.A., Mordes J.P., et al. Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody. J. Virol. 2000, 74:2210-2218.
31. Ehl S., Hombach J., Aichele P., Rulicke T., Odermatt B., Hengartner H., et al. Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathology. J. Exp. Med. 1998, 187:763-774.