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Volumn 55, Issue 6, 2010, Pages 585-594

Preventing serious sequelae after an acute coronary syndrome: The consequences of thrombosis versus bleeding with antiplatelet therapy

Author keywords

acute coronary syndrome; aspirin; bleeding; clopidogrel; ischemic events; prasugrel

Indexed keywords

ACETYLSALICYLIC ACID; CIMETIDINE; CLOPIDOGREL; OMEPRAZOLE; PRASUGREL; TICLOPIDINE; ANTITHROMBOCYTIC AGENT; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; THIENOPYRIDINE DERIVATIVE; THIOPHENE DERIVATIVE;

EID: 77953811193     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3181d9f81f     Document Type: Review
Times cited : (7)

References (82)
  • 1
    • 34548545280 scopus 로고    scopus 로고
    • ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: A report of the American College of Cardiology
    • Anderson JL, Adams CD, Antman EM, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (writing committee to revise the 2002 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction): developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Circulation. 2007;116:e148-e304.
    • (2007) Circulation , vol.116
    • Anderson, J.L.1    Adams, C.D.2    Antman, E.M.3
  • 2
    • 24944513945 scopus 로고    scopus 로고
    • Atherothrombosis and high-risk plaque: Part I: Evolving concepts
    • Fuster V, Moreno PR, Fayad ZA, et al. Atherothrombosis and high-risk plaque: part I: evolving concepts. J Am Coll Cardiol. 2005; 46:937-954.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 937-954
    • Fuster, V.1    Moreno, P.R.2    Fayad, Z.A.3
  • 3
    • 42649106501 scopus 로고    scopus 로고
    • Aspirin and platelet adenosine diphosphate receptor antagonists in acute coronary syndromes and percutaneous coronary intervention: Role in therapy and strategies to overcome resistance
    • Depta JP, Bhatt DL. Aspirin and platelet adenosine diphosphate receptor antagonists in acute coronary syndromes and percutaneous coronary intervention: role in therapy and strategies to overcome resistance. Am J Cardiovasc Drugs. 2008;8:91-112.
    • (2008) Am J Cardiovasc Drugs , vol.8 , pp. 91-112
    • Depta, J.P.1    Bhatt, D.L.2
  • 4
    • 10944239058 scopus 로고    scopus 로고
    • ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction)
    • Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction). Circulation. 2004;110:e82-e292.
    • (2004) Circulation , vol.110
    • Antman, E.M.1    Anbe, D.T.2    Armstrong, P.W.3
  • 5
    • 0037065502 scopus 로고    scopus 로고
    • Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
    • Antithrombotic Trialists' Collaboration
    • Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002;324:71-86.
    • (2002) BMJ , vol.324 , pp. 71-86
  • 7
    • 0031814242 scopus 로고    scopus 로고
    • Adverse haematological effects of ticlopidine. Prevention, recognition and management
    • Love BB, Biller J, Gent M. Adverse haematological effects of ticlopidine. Prevention, recognition and management. Drug Saf. 1998;19:89-98.
    • (1998) Drug Saf , vol.19 , pp. 89-98
    • Love, B.B.1    Biller, J.2    Gent, M.3
  • 8
    • 38049169354 scopus 로고    scopus 로고
    • Focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: 2007 writing group to review new evidence and update the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention, writing on behalf of the 2005 writing committee
    • King SB III, Smith SC Jr, Hirshfeld JW Jr, et al. 2007 focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: 2007 writing group to review new evidence and update the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention, writing on behalf of the 2005 writing committee. Circulation. 2008;117:261-295.
    • (2007) Circulation. , vol.117 , pp. 261-295
    • King III, S.B.1    Smith Jr., S.C.2    Hirshfeld Jr., J.W.3
  • 9
    • 33645861080 scopus 로고    scopus 로고
    • Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events
    • Bhatt DL, Fox KA, Hacke W, et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med. 2006; 354:1706-1717.
    • (2006) N Engl J Med , vol.354 , pp. 1706-1717
    • Bhatt, D.L.1    Fox, K.A.2    Hacke, W.3
  • 10
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without STsegment elevation
    • Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
    • Yusuf S, Zhao F, Mehta SR, et al; Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without STsegment elevation. N Engl J Med. 2001;345:494-502.
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3
  • 11
    • 27644548513 scopus 로고    scopus 로고
    • Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: Randomised placebo-controlled trial
    • COMMIT Collaborative Group
    • Chen ZM, Jiang LX, Chen YP, et al; COMMIT Collaborative Group. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet. 2005;366:1607-1621.
    • (2005) Lancet , vol.366 , pp. 1607-1621
    • Chen, Z.M.1    Jiang, L.X.2    Chen, Y.P.3
  • 12
    • 0037145863 scopus 로고    scopus 로고
    • Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial
    • CREDO Investigators
    • Steinhubl SR, Berger PB, Mann JT III, et al; CREDO Investigators. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA. 2002;288:2411-2420.
    • (2002) JAMA , vol.288 , pp. 2411-2420
    • Steinhubl, S.R.1    Berger, P.B.2    Mann III, J.T.3
  • 13
    • 28244459634 scopus 로고    scopus 로고
    • Low-dose aspirin for the prevention of atherothrombosis
    • Patrono C, Garcia Rodriguez LA, Landolfi R, et al. Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med. 2005;353:2373-2383.
    • (2005) N Engl J Med , vol.353 , pp. 2373-2383
    • Patrono, C.1    Garcia Rodriguez, L.A.2    Landolfi, R.3
  • 14
    • 60549115629 scopus 로고    scopus 로고
    • The potential role of prasugrel in secondary prevention of ischemic events in patients with acute coronary syndromes
    • Toth PP. The potential role of prasugrel in secondary prevention of ischemic events in patients with acute coronary syndromes. Postgrad Med. 2009;121:59-72.
    • (2009) Postgrad Med , vol.121 , pp. 59-72
    • Toth, P.P.1
  • 15
    • 33645052218 scopus 로고    scopus 로고
    • ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI writing committee to update 2001 guidelines for percutaneous coronary intervention)
    • Smith SC Jr, Feldman TE, Hirshfeld JW Jr, et al. ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI writing committee to update 2001 guidelines for percutaneous coronary intervention). Circulation. 2006;113:e166-e286.
    • (2006) Circulation , vol.113
    • Smith Jr., S.C.1    Feldman, T.E.2    Hirshfeld Jr., J.W.3
  • 16
    • 45549105580 scopus 로고    scopus 로고
    • Aspirin in coronary artery bypass surgery: New aspects of and alternatives for an old antithrombotic agent
    • Zimmermann N, Gams E, Hohlfeld T. Aspirin in coronary artery bypass surgery: new aspects of and alternatives for an old antithrombotic agent. Eur J Cardiothorac Surg. 2008;34:93-108.
    • (2008) Eur J Cardiothorac Surg , vol.34 , pp. 93-108
    • Zimmermann, N.1    Gams, E.2    Hohlfeld, T.3
  • 18
    • 0035908781 scopus 로고    scopus 로고
    • Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study
    • Clopidogrel in Unstable angina to prevent Recurrent Events Trial Investigators
    • Mehta SR, Yusuf S, Peters RJ, et al; Clopidogrel in Unstable angina to prevent Recurrent Events Trial Investigators. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358:527-533.
    • (2001) Lancet , vol.358 , pp. 527-533
    • Mehta, S.R.1    Yusuf, S.2    Peters, R.J.3
  • 19
    • 6944222791 scopus 로고    scopus 로고
    • Comparative benefits of clopidogrel and aspirin in high-risk patient populations: Lessons from the CAPRIE and CURE studies
    • Hirsh J, Bhatt DL. Comparative benefits of clopidogrel and aspirin in high-risk patient populations: lessons from the CAPRIE and CURE studies. Arch Intern Med. 2004;164:2106-2110.
    • (2004) Arch Intern Med , vol.164 , pp. 2106-2110
    • Hirsh, J.1    Bhatt, D.L.2
  • 20
    • 50649123533 scopus 로고    scopus 로고
    • Time course of events in acute coronary syndromes: Implications for clinical practice from the GRACE registry
    • GRACE Investigators
    • Fox KA, Anderson FA Jr, Goodman SG, et al; GRACE Investigators. Time course of events in acute coronary syndromes: implications for clinical practice from the GRACE registry. Nat Clin Pract Cardiovasc Med. 2008;5:580-589.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 580-589
    • Fox, K.A.1    Anderson Jr., F.A.2    Goodman, S.G.3
  • 21
    • 0032480752 scopus 로고    scopus 로고
    • Acute coronary syndromes in the GUSTO-IIb trial: Prognostic insights and impact of recurrent ischemia
    • Armstrong PW, Fu Y, Chang WC, et al. Acute coronary syndromes in the GUSTO-IIb trial: prognostic insights and impact of recurrent ischemia. Circulation. 1998;98:1860-1868.
    • (1998) Circulation , vol.98 , pp. 1860-1868
    • Armstrong, P.W.1    Fu, Y.2    Chang, W.C.3
  • 22
    • 50949116443 scopus 로고    scopus 로고
    • Incidence of coronary stent thrombosis based on academic research consortium definitions
    • Applegate RJ, Sacrinty MT, Little WC, et al. Incidence of coronary stent thrombosis based on academic research consortium definitions. Am J Cardiol. 2008;102:683-688.
    • (2008) Am J Cardiol , vol.102 , pp. 683-688
    • Applegate, R.J.1    Sacrinty, M.T.2    Little, W.C.3
  • 23
    • 0034670111 scopus 로고    scopus 로고
    • Comparison of activation process of platelets and neutrophils after coronary stent implantation versus balloon angioplasty for stable angina pectoris
    • Inoue T, Sohma R, Miyazaki T, et al. Comparison of activation process of platelets and neutrophils after coronary stent implantation versus balloon angioplasty for stable angina pectoris. Am J Cardiol. 2000;86:1057-1062.
    • (2000) Am J Cardiol , vol.86 , pp. 1057-1062
    • Inoue, T.1    Sohma, R.2    Miyazaki, T.3
  • 24
    • 21044444052 scopus 로고    scopus 로고
    • Magnitude of and risk factors for inhospital and postdischarge stroke in patients with acute coronary syndromes: Findings from a Global Registry of Acute Coronary Events
    • Budaj A, Flasinska K, Gore JM, et al. Magnitude of and risk factors for inhospital and postdischarge stroke in patients with acute coronary syndromes: findings from a Global Registry of Acute Coronary Events. Circulation. 2005;111:3242-3247.
    • (2005) Circulation , vol.111 , pp. 3242-3247
    • Budaj, A.1    Flasinska, K.2    Gore, J.M.3
  • 25
    • 33750332481 scopus 로고    scopus 로고
    • Short-term and long-term outcomes in 133429 emergency patients admitted with angina or myocardial infarction in Scotland 1990-2000: Population-based cohort study
    • Capewell S, Murphy NF, MacIntyre K, et al. Short-term and long-term outcomes in 133,429 emergency patients admitted with angina or myocardial infarction in Scotland, 1990-2000: population-based cohort study. Heart. 2006;92:1563-1570.
    • (2006) Heart , vol.92 , pp. 1563-1570
    • Capewell, S.1    Murphy, N.F.2    MacIntyre, K.3
  • 26
    • 27444432436 scopus 로고    scopus 로고
    • Management and outcomes of lower risk patients presenting with acute coronary syndromes in a multinational observational registry
    • Devlin G, Anderson FA, Heald S, et al. Management and outcomes of lower risk patients presenting with acute coronary syndromes in a multinational observational registry. Heart. 2005;91:1394-1399.
    • (2005) Heart , vol.91 , pp. 1394-1399
    • Devlin, G.1    Anderson, F.A.2    Heald, S.3
  • 27
    • 4644280096 scopus 로고    scopus 로고
    • Incidence and characteristics of stroke during 90-day follow-up in patients stabilized after an acute coronary syndrome
    • Kassem-Moussa H, Mahaffey KW, Graffagnino C, et al. Incidence and characteristics of stroke during 90-day follow-up in patients stabilized after an acute coronary syndrome. Am Heart J. 2004;148:439-446.
    • (2004) Am Heart J , vol.148 , pp. 439-446
    • Kassem-Moussa, H.1    Mahaffey, K.W.2    Graffagnino, C.3
  • 28
    • 20244385465 scopus 로고    scopus 로고
    • Gender differences in outcomes after primary angioplasty versus primary stenting with and without abciximab for acute myocardial infarction: Results of the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trial
    • Lansky AJ, Pietras C, Costa RA, et al. Gender differences in outcomes after primary angioplasty versus primary stenting with and without abciximab for acute myocardial infarction: results of the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trial. Circulation. 2005;111:1611-1618.
    • (2005) Circulation , vol.111 , pp. 1611-1618
    • Lansky, A.J.1    Pietras, C.2    Costa, R.A.3
  • 29
    • 43449104544 scopus 로고    scopus 로고
    • Race and sex differences in thrombogenicity: Risk of ischemic events following coronary stenting
    • Gurbel PA, Bliden KP, Cohen E, et al. Race and sex differences in thrombogenicity: risk of ischemic events following coronary stenting. Blood Coagul Fibrinolysis. 2008;19:268-275.
    • (2008) Blood Coagul Fibrinolysis , vol.19 , pp. 268-275
    • Gurbel, P.A.1    Kp, B.2    Cohen, E.3
  • 30
    • 0035845658 scopus 로고    scopus 로고
    • Vascular biology of thrombosis: Platelet-vessel wall interactions and aspirin effects
    • Catella-Lawson F. Vascular biology of thrombosis: platelet-vessel wall interactions and aspirin effects. Neurology. 2001;57:S5-S7.
    • (2001) Neurology , vol.57
    • Catella-Lawson, F.1
  • 31
    • 8344231455 scopus 로고    scopus 로고
    • Aspirin and clopidogrel: Efficacy, safety, and the issue of drug resistance
    • Cattaneo M. Aspirin and clopidogrel: efficacy, safety, and the issue of drug resistance. Arterioscler Thromb Vasc Biol. 2004;24:1980-1987.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1980-1987
    • Cattaneo, M.1
  • 32
    • 34447576539 scopus 로고    scopus 로고
    • Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: A systematic review and meta-analysis
    • Snoep JD, Hovens MM, Eikenboom JC, et al. Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: a systematic review and meta-analysis. Am Heart J. 2007; 154:221-231.
    • (2007) Am Heart J , vol.154 , pp. 221-231
    • Snoep, J.D.1    Hovens, M.M.2    Eikenboom, J.C.3
  • 33
    • 2942656827 scopus 로고    scopus 로고
    • Aspirin in cardiovascular disorders. What is the optimum dose?
    • Kong DF. Aspirin in cardiovascular disorders. What is the optimum dose? Am J Cardiovasc Drugs. 2004;4:151-158.
    • (2004) Am J Cardiovasc Drugs , vol.4 , pp. 151-158
    • Kong, D.F.1
  • 34
    • 38949119325 scopus 로고    scopus 로고
    • Aspirin "resistance" and risk of cardiovascular morbidity: Systematic review and meta-analysis
    • Krasopoulos G, Brister SJ, Beattie WS, et al. Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysis. BMJ. 2008;336:195-198.
    • (2008) BMJ , vol.336 , pp. 195-198
    • Krasopoulos, G.1    Brister, S.J.2    Beattie, W.S.3
  • 35
    • 35048856897 scopus 로고    scopus 로고
    • ADP-induced platelet aggregation and platelet reactivity index VASP are good predictive markers for clinical outcomes in non-ST elevation acute coronary syndrome
    • Frere C, Cuisset T, Quilici J, et al. ADP-induced platelet aggregation and platelet reactivity index VASP are good predictive markers for clinical outcomes in non-ST elevation acute coronary syndrome. Thromb Haemost. 2007;98:838-843.
    • (2007) Thromb Haemost , vol.98 , pp. 838-843
    • Frere, C.1    Cuisset, T.2    Quilici, J.3
  • 36
    • 38949112887 scopus 로고    scopus 로고
    • Residual prothrombotic status in low responder patients to clopidogrel identified by vasodilator-stimulated phosphoprotein phosphorylation (VASP) analysis?
    • Morel O, Bernhard N, Desprez D, et al. Residual prothrombotic status in low responder patients to clopidogrel identified by vasodilator-stimulated phosphoprotein phosphorylation (VASP) analysis? Thromb Haemost. 2008;99:448-451.
    • (2008) Thromb Haemost , vol.99 , pp. 448-451
    • Morel, O.1    Bernhard, N.2    Desprez, D.3
  • 37
    • 33845451677 scopus 로고    scopus 로고
    • A comparison of prasugrel and clopidogrel loading doses on platelet function: Magnitude of platelet inhibition is related to active metabolite formation
    • Brandt JT, Payne CD, Wiviott SD, et al. A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation. Am Heart J. 2007;153: 66, e9-e16.
    • (2007) Am Heart J , vol.153 , Issue.66
    • Brandt, J.T.1    Payne, C.D.2    Wiviott, S.D.3
  • 38
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • Gurbel PA, Bliden KP, Hiatt BL, et al. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation. 2003;107:2908-2913.
    • (2003) Circulation , vol.107 , pp. 2908-2913
    • Gurbel, P.A.1    Kp, B.2    Hiatt, B.L.3
  • 39
    • 75749122646 scopus 로고    scopus 로고
    • Bridgewater NJ: Bristol-Myers Squibb/Sanofi Pharmaceutical
    • Plavix [package insert]. Bridgewater, NJ: Bristol-Myers Squibb/Sanofi Pharmaceutical; 2009.
    • (2009) Plavix [Package Insert]
  • 40
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome P-450 polymorphisms and response to clopidogrel
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome P-450 polymorphisms and response to clopidogrel. N Engl J Med. 2009;360:354-362.
    • (2009) N Engl J Med , vol.360 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 41
    • 38349065084 scopus 로고    scopus 로고
    • Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: The randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study
    • Gilard M, Arnaud B, Cornily JC, et al. Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. J Am Coll Cardiol. 2008;51:256-260.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 256-260
    • Gilard, M.1    Arnaud, B.2    Cornily, J.C.3
  • 42
    • 67651097806 scopus 로고    scopus 로고
    • Drug-drug interaction between clopidogrel and the proton pump inhibitors
    • Norgard NB, Mathews KD, Wall GC. Drug-drug interaction between clopidogrel and the proton pump inhibitors. Ann Pharmacother. 2009;43: 1266-1274.
    • (2009) Ann Pharmacother , vol.43 , pp. 1266-1274
    • Norgard, N.B.1    Mathews, K.D.2    Wall, G.C.3
  • 43
    • 79961130051 scopus 로고    scopus 로고
    • Risk of adverse clinical outcomes with concomitant use of clopidogrel and proton pump inhibitors following percutaneous coronary intervention
    • [Epub ahead of print]
    • Gupta E, Bansal D, Sotos J, et al. Risk of adverse clinical outcomes with concomitant use of clopidogrel and proton pump inhibitors following percutaneous coronary intervention. Dig Dis Sci. 2009 [Epub ahead of print].
    • (2009) Dig Dis Sci
    • Gupta, E.1    Bansal, D.2    Sotos, J.3
  • 44
    • 64849087438 scopus 로고    scopus 로고
    • Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel
    • Sibbing D, Morath T, Stegherr J, et al. Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel. Thromb Haemost. 2009;101:714-719.
    • (2009) Thromb Haemost , vol.101 , pp. 714-719
    • Sibbing, D.1    Morath, T.2    Stegherr, J.3
  • 46
    • 77952359072 scopus 로고    scopus 로고
    • COGENT: A prospective, randomized, placebo-controlled trial of omeprazole in patients receiving aspirin and clopidogrel
    • Presented at, September 24, San Francisco, CA
    • Bhatt D, Cryer B, Contant C, et al. COGENT: a prospective, randomized, placebo-controlled trial of omeprazole in patients receiving aspirin and clopidogrel. Presented at 21st Annual Transcatheter Cardiovascular Therapeutics (TCT) Meeting, September 24, 2009, San Francisco, CA.
    • (2009) 21st Annual Transcatheter Cardiovascular Therapeutics (TCT) Meeting
    • Bhatt, D.1    Cryer, B.2    Contant, C.3
  • 47
    • 77953806599 scopus 로고    scopus 로고
    • OASIS7 trial results: A randomized comparison of a clopidogrel high loading and maintenance dose regimen versus standard dose and high versus lowdose aspirin in 25,000 patients with acute coronary syndromes
    • Presented at, August 30, 2009, Barcelona, Spain
    • Mehta S.OASIS7 trial results: a randomized comparison of a clopidogrel high loading and maintenance dose regimen versus standard dose and high versus lowdose aspirin in 25,000 patients with acute coronary syndromes. Presented at European Society of Cardiology, August 30, 2009, Barcelona, Spain.
    • European Society of Cardiology
    • Mehta, S.1
  • 48
    • 56849130022 scopus 로고    scopus 로고
    • Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo
    • Erlinge D, Varenhorst C, Braun OO, et al. Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo. J Am Coll Cardiol. 2008;52:1968-1977.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1968-1977
    • Erlinge, D.1    Varenhorst, C.2    Braun, O.O.3
  • 49
    • 33947284488 scopus 로고    scopus 로고
    • A multiple dose study of prasugrel (CS-747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humans
    • Jakubowski JA, Matsushima N, Asai F, et al. A multiple dose study of prasugrel (CS-747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humans. Br J Clin Pharmacol. 2007;63: 421-430.
    • (2007) Br J Clin Pharmacol , vol.63 , pp. 421-430
    • Jakubowski, J.A.1    Matsushima, N.2    Asai, F.3
  • 50
    • 34147207681 scopus 로고    scopus 로고
    • Dose-dependent inhibition of human platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects
    • Jakubowski JA, Payne CD, Weerakkody GJ, et al. Dose-dependent inhibition of human platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects. J Cardiovasc Pharmacol. 2007;49: 167-173.
    • (2007) J Cardiovasc Pharmacol , vol.49 , pp. 167-173
    • Jakubowski, J.A.1    Payne, C.D.2    Weerakkody, G.J.3
  • 51
    • 66349133650 scopus 로고    scopus 로고
    • Cytochrome P450 genetic polymorphisms and the response to prasugrel: Relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation. 2009; 119:2553-2560.
    • (2009) Circulation , vol.119 , pp. 2553-2560
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 52
    • 0141483373 scopus 로고    scopus 로고
    • Incidence, predictors, and prognostic implications of bleeding and blood transfusion following percutaneous coronary interventions
    • Kinnaird TD, Stabile E, Mintz GS, et al. Incidence, predictors, and prognostic implications of bleeding and blood transfusion following percutaneous coronary interventions. Am J Cardiol. 2003;92:930-935.
    • (2003) Am J Cardiol , vol.92 , pp. 930-935
    • Kinnaird, T.D.1    Stabile, E.2    Mintz, G.S.3
  • 53
    • 0142041382 scopus 로고    scopus 로고
    • Predictors of major bleeding in acute coronary syndromes: The Global Registry of Acute Coronary Events GRACE
    • Moscucci M, Fox KA, Cannon CP, et al. Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events GRACE. Eur Heart J. 2003;24:1815-1823.
    • (2003) Eur Heart J , vol.24 , pp. 1815-1823
    • Moscucci, M.1    Fox, K.A.2    Cannon, C.P.3
  • 54
    • 37349125565 scopus 로고    scopus 로고
    • Does comorbidity account for the excess mortality in patients with major bleeding in acute myocardial infarction?
    • Spencer FA, Moscucci M, Granger CB, et al. Does comorbidity account for the excess mortality in patients with major bleeding in acute myocardial infarction? Circulation. 2007;116:2793-2801.
    • (2007) Circulation , vol.116 , pp. 2793-2801
    • Spencer, F.A.1    Moscucci, M.2    Granger, C.B.3
  • 55
    • 35448999729 scopus 로고    scopus 로고
    • Meta-analysis of clinical efficacy and bleeding risk with intravenous glycoprotein IIb/IIIa antagonists for percutaneous coronary intervention
    • Labinaz M, Ho C, Banerjee S, et al. Meta-analysis of clinical efficacy and bleeding risk with intravenous glycoprotein IIb/IIIa antagonists for percutaneous coronary intervention. Can J Cardiol. 2007;23:963-970.
    • (2007) Can J Cardiol , vol.23 , pp. 963-970
    • Labinaz, M.1    Ho, C.2    Banerjee, S.3
  • 56
    • 0035895332 scopus 로고    scopus 로고
    • Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: A meta-analysis of phase III multicenter randomized trials
    • Chew DP, Bhatt DL, Sapp S, et al. Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: a meta-analysis of phase III multicenter randomized trials. Circulation. 2001;103:201-206.
    • (2001) Circulation , vol.103 , pp. 201-206
    • Chew, D.P.1    Bhatt, D.L.2    Sapp, S.3
  • 57
    • 42549127867 scopus 로고    scopus 로고
    • Bleeding and transfusion in acute coronary syndromes: A shift in the paradigm
    • Bassand JP. Bleeding and transfusion in acute coronary syndromes: a shift in the paradigm. Heart. 2008;94:661-666.
    • (2008) Heart , vol.94 , pp. 661-666
    • Bassand, J.P.1
  • 58
    • 37349090785 scopus 로고    scopus 로고
    • Bleeding is bad.. isn't it?
    • Berger PB, Manoukian SV. Bleeding is bad.. isn't it? Circulation. 2007; 116:2776-2778.
    • (2007) Circulation , vol.116 , pp. 2776-2778
    • Berger, P.B.1    Manoukian, S.V.2
  • 59
    • 33747599590 scopus 로고    scopus 로고
    • Adverse impact of bleeding on prognosis in patients with acute coronary syndromes
    • Eikelboom JW, Mehta SR, Anand SS, et al. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation. 2006; 114:774-782.
    • (2006) Circulation , vol.114 , pp. 774-782
    • Eikelboom, J.W.1    Mehta, S.R.2    Anand, S.S.3
  • 60
    • 33947575142 scopus 로고    scopus 로고
    • Impact of major bleeding on 30-day mortality and clinical outcomes in patientswith acute coronary syndromes: An analysis from the ACUITY trial
    • Manoukian SV, Feit F, Mehran R, et al. Impact of major bleeding on 30-day mortality and clinical outcomes in patientswith acute coronary syndromes: an analysis from the ACUITY trial. J Am Coll Cardiol. 2007;49:1362-1368.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1362-1368
    • Manoukian, S.V.1    Feit, F.2    Mehran, R.3
  • 61
    • 33745100237 scopus 로고    scopus 로고
    • Rebound platelet activation after termination of prasugrel and aspirin therapy due to confirmed noncompliance in patient enrolled in the JUMBO trial
    • Serebruany VL, Midei MG, Meilman H, et al. Rebound platelet activation after termination of prasugrel and aspirin therapy due to confirmed noncompliance in patient enrolled in the JUMBO trial. Int J Clin Pract. 2006; 60:863-866.
    • (2006) Int J Clin Pract , vol.60 , pp. 863-866
    • Serebruany, V.L.1    Midei, M.G.2    Meilman, H.3
  • 62
    • 56849091335 scopus 로고    scopus 로고
    • Antiplatelet therapy: Anti-ischemic benefits versus bleeding risk
    • October 24
    • Gibson CM. Antiplatelet therapy: anti-ischemic benefits versus bleeding risk. J Interv Cardiol. October 24, 2008;21:S3-S9.
    • (2008) J Interv Cardiol , vol.21
    • Gibson, C.M.1
  • 64
    • 52449119284 scopus 로고    scopus 로고
    • Which parameters differ in very old patients with chronic atrial fibrillation treated by anticoagulant or aspirin?
    • Doucet J, Greboval-Furstenfeld E, Tavildari A, et al. Which parameters differ in very old patients with chronic atrial fibrillation treated by anticoagulant or aspirin? Fundam Clin Pharmacol. 2008;22:569-574.
    • (2008) Fundam Clin Pharmacol , vol.22 , pp. 569-574
    • Doucet, J.1    Greboval-Furstenfeld, E.2    Tavildari, A.3
  • 65
    • 34547544906 scopus 로고    scopus 로고
    • Antiplatelet therapy in patients with unstable angina and non-ST-segment-elevation myocardial infarction: Findings from the CRUSADE national quality improvement initiative
    • Bottorff MB, Nutescu EA, Spinler S, et al. Antiplatelet therapy in patients with unstable angina and non-ST-segment-elevation myocardial infarction: findings from the CRUSADE national quality improvement initiative. Pharmacotherapy. 2007;27:1145-1162.
    • (2007) Pharmacotherapy , vol.27 , pp. 1145-1162
    • Bottorff, M.B.1    Nutescu, E.A.2    Spinler, S.3
  • 66
    • 33846828736 scopus 로고    scopus 로고
    • Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents: A science advisory from the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association, with representation from the American College of Physicians
    • Grines CL, Bonow RO, Casey DE Jr, et al. Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents: a science advisory from the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association, with representation from the American College of Physicians. J Am Coll Cardiol. 2007;49:734-739.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 734-739
    • Grines, C.L.1    Bonow, R.O.2    Casey Jr., D.E.3
  • 67
    • 0034070620 scopus 로고    scopus 로고
    • Catastrophic outcomes of noncardiac surgery soon after coronary stenting
    • Kaluza GL, Joseph J, Lee JR, et al. Catastrophic outcomes of noncardiac surgery soon after coronary stenting. J Am Coll Cardiol. 2000;35: 1288-1294.
    • (2000) J Am Coll Cardiol , vol.35 , pp. 1288-1294
    • Kaluza, G.L.1    Joseph, J.2    Lee, J.R.3
  • 68
    • 23044491986 scopus 로고    scopus 로고
    • Late thrombosis of sirolimuseluting stents following noncardiac surgery
    • Nasser M, Kapeliovich M, Markiewicz W. Late thrombosis of sirolimuseluting stents following noncardiac surgery. Catheter Cardiovasc Interv. 2005;65:516-519.
    • (2005) Catheter Cardiovasc Interv , vol.65 , pp. 516-519
    • Nasser, M.1    Kapeliovich, M.2    Markiewicz, W.3
  • 69
    • 4744345959 scopus 로고    scopus 로고
    • Major noncardiac surgery following coronary stenting: When is it safe to operate?
    • Sharma AK, Ajani AE, Hamwi SM, et al. Major noncardiac surgery following coronary stenting: when is it safe to operate? Catheter Cardiovasc Interv. 2004;63:141-145.
    • (2004) Catheter Cardiovasc Interv , vol.63 , pp. 141-145
    • Sharma, A.K.1    Ajani, A.E.2    Hamwi, S.M.3
  • 70
    • 1842423453 scopus 로고    scopus 로고
    • Antiplatelet drug discontinuation is a risk factor for ischemic stroke
    • Sibon I, Orgogozo JM. Antiplatelet drug discontinuation is a risk factor for ischemic stroke. Neurology. 2004;62:1187-1189.
    • (2004) Neurology , vol.62 , pp. 1187-1189
    • Sibon, I.1    Orgogozo, J.M.2
  • 71
    • 38349018499 scopus 로고    scopus 로고
    • Association between bleeding, blood transfusion, and costs among patients with non-ST-segment elevation acute coronary syndromes
    • Rao SV, Kaul PR, Liao L, et al. Association between bleeding, blood transfusion, and costs among patients with non-ST-segment elevation acute coronary syndromes. Am Heart J. 2008;155:369-374.
    • (2008) Am Heart J , vol.155 , pp. 369-374
    • Rao, S.V.1    Kaul, P.R.2    Liao, L.3
  • 72
    • 13444269008 scopus 로고    scopus 로고
    • A cost-effectiveness analysis of combination antiplatelet therapy for high-risk acute coronary syndromes: Clopidogrel plus aspirin versus aspirin alone
    • Schleinitz MD, Heidenreich PA. A cost-effectiveness analysis of combination antiplatelet therapy for high-risk acute coronary syndromes: clopidogrel plus aspirin versus aspirin alone. Ann Intern Med. 2005;142: 251-259.
    • (2005) Ann Intern Med , vol.142 , pp. 251-259
    • Schleinitz, M.D.1    Heidenreich, P.A.2
  • 73
    • 77953809420 scopus 로고    scopus 로고
    • Index, follow-up and total hospitalization costs in patients with acute coronary syndromes undergoing planned percutaneous coronary intervention treated with prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial
    • Presented at, October 24, Athens, Greece
    • Mahoney EM, Wang K, Arnold SV, et al. Index, follow-up and total hospitalization costs in patients with acute coronary syndromes undergoing planned percutaneous coronary intervention treated with prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial. Presented at International Society for Pharmacoeconomics and Outcomes Research 11th Annual European Congress, October 24, 2008, Athens, Greece.
    • (2008) International Society for Pharmacoeconomics and Outcomes Research 11th Annual European Congress
    • Mahoney, E.M.1    Wang, K.2    Arnold, S.V.3
  • 74
    • 21644448736 scopus 로고    scopus 로고
    • Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: Results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial
    • JUMBO-TIMI Investigators
    • Wiviott SD, Antman EM, Winters KJ, et al; JUMBO-TIMI Investigators. Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial. Circulation. 2005; 111:3366-3373.
    • (2005) Circulation , vol.111 , pp. 3366-3373
    • Wiviott, S.D.1    Antman, E.M.2    Winters, K.J.3
  • 76
    • 42149119040 scopus 로고    scopus 로고
    • Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: A subanalysis of a randomised trial
    • TRITON-TIMI Investigators
    • Wiviott SD, Braunwald E, McCabe CH, et al; TRITON-TIMI Investigators. Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomised trial. Lancet. 2008;371:1353-1363.
    • (2008) Lancet , vol.371 , pp. 1353-1363
    • Wiviott, S.D.1    Braunwald, E.2    Ch, M.3
  • 77
    • 60649112469 scopus 로고    scopus 로고
    • Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): Double-blind, randomised controlled trial
    • Montalescot G, Wiviott SD, Braunwald E, et al. Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial. Lancet. 2009;373:723-731.
    • (2009) Lancet , vol.373 , pp. 723-731
    • Montalescot, G.1    Wiviott, S.D.2    Braunwald, E.3
  • 78
    • 55949103494 scopus 로고    scopus 로고
    • Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel- Thrombolysis in Myocardial Infarction 38
    • Wiviott SD, Braunwald E, Angiolillo DJ, et al. Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel- Thrombolysis in Myocardial Infarction 38. Circulation. 2008;118:1626-1636.
    • (2008) Circulation , vol.118 , pp. 1626-1636
    • Wiviott, S.D.1    Braunwald, E.2    Angiolillo, D.J.3
  • 79
    • 36148940945 scopus 로고    scopus 로고
    • Intensifying platelet inhibition-navigating between Scylla and Charybdis
    • Bhatt DL. Intensifying platelet inhibition-navigating between Scylla and Charybdis. N Engl J Med. 2007;357:2078-2081.
    • (2007) N Engl J Med , vol.357 , pp. 2078-2081
    • Dlss, B.1
  • 80
    • 77953810201 scopus 로고    scopus 로고
    • Division of Cardiovascular and Renal Products. Food and Drug Administration Center for Drug Evaluation and Research; January 9
    • Division of Cardiovascular and Renal Products. Revised Secondary CDTL Review for NDA 22-307. EFFIENTTM (prasugrel hydrochloride) Tablets. Food and Drug Administration Center for Drug Evaluation and Research; January 9, 2009.
    • (2009) Revised Secondary CDTL Review for NDA 22-307. EFFIENTTM (Prasugrel Hydrochloride) Tablets
  • 81
    • 28744435644 scopus 로고    scopus 로고
    • Upper gastrointestinal haemorrhage complicating antiplatelet treatment with aspirin and/or clopidogrel: Where we are now?
    • Liberopoulos EN, Elisaf MS, Tselepis AD, et al. Upper gastrointestinal haemorrhage complicating antiplatelet treatment with aspirin and/or clopidogrel: where we are now? Platelets. 2006;17:1-6.
    • (2006) Platelets , vol.17 , pp. 1-6
    • Liberopoulos, E.N.1    Elisaf, M.S.2    Tselepis, A.D.3
  • 82
    • 0141919739 scopus 로고    scopus 로고
    • Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: Observations from the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) study
    • Peters RJ, Mehta SR, Fox KA, et al. Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) study. Circulation. 2003;108:1682-1687.
    • (2003) Circulation , vol.108 , pp. 1682-1687
    • Peters, R.J.1    Mehta, S.R.2    Fox, K.A.3


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