Relationship between paraoxonase-1 activity, carotid intima-media thickness and arterial stiffness in hypertensive patients

Journal of Human Hypertension

Volumn 24, Issue 7, 2010, Pages 492-494

  Yang, W I ^a   Lee, S H ^a   Ko, Y G ^a   Kang, S M ^a   Choi, D ^a   Ha, J W ^a   Hong, M K ^a   Chung, N ^a   Shim, W H ^a   Cho, S Y ^a   Jang, Y ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLDIALKYLPHOSPHATASE 1; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; ARYLDIALKYLPHOSPHATASE; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PON1 PROTEIN, HUMAN;

ARTERIAL STIFFNESS; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; CAROTID ARTERY; DISEASE ASSOCIATION; DISEASE MARKER; ENZYME ACTIVITY; FEMORAL ARTERY; HEART; HUMAN; HYPERTENSION; PULSE WAVE; AGE; DYSLIPIDEMIAS; ENZYMOLOGY; FEMALE; INTIMA; MALE; METABOLISM; PATHOLOGY;

AGE FACTORS; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTIHYPERTENSIVE AGENTS; ARYLDIALKYLPHOSPHATASE; ATHEROSCLEROSIS; CALCIUM CHANNEL BLOCKERS; CAROTID ARTERIES; DYSLIPIDEMIAS; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERTENSION; MALE; TUNICA INTIMA;

EID: 77953810664     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/jhh.2010.10     Document Type: Article

References (12)

1. Parthasarathy S, Barnett J, Fong LG. High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein. Biochim Biophys Acta 1990; 1044: 275-283.
2. Watson AD, Berliner JA, Hama SY, La Du BN, Faull KF, Fogelman AM et al. Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein. J Clin Invest 1995; 96: 2882-2891.
3. Granér M, James RW, Kahri J, Nieminen MS, Syvänne M, Taskinen MR. Association of paraoxonase-1 activity and concentration with angiographic severity and extent of coronary artery disease. J Am Coll Cardiol 2006; 47: 2429-2435. (Pubitemid 43866362)
4. Park S, Kim JB, Shim CY, Ko YG, Choi D, Jang Y et al. The influence of serum aldosterone and the aldosterone- renin ratio on pulse wave velocity in hypertensive patients. J Hypertens 2007; 25: 1279-1283.
5. Shih DM, Gu L, Xia YR, Navab M, Li WF, Hama S et al. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature 1998; 394: 284-287.
6. Tward A, Xia YR, Wang XP, Shi YS, Park C, Castellani LW et al. Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation 2002; 106: 484-490.
7. Tavori H, Aviram M, Khatib S, Musa R, Nitecki S, Hoffman A et al. Human carotid atherosclerotic plaque increases oxidative state of macrophages and low-density lipoproteins, whereas paraoxonase 1 (PON1) decreases such atherogenic effects. Free Radic Biol Med 2009; 46: 607-615.
8. Lacinski M, Skorupski W, Cieslinski A, Sokolowska J, Trzeciak WH, Jakubowski H. Determinants of homocysteine- thiolactonase activity of the paraoxonase-1 (PON1) protein in humans. Cell Mol Biol 2004; 50: 885-893.
9. Bhattacharyya T, Nicholls SJ, Topol EJ, Zhang R, Yang X, Schmitt D et al. Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA 2008; 299: 1265-1276.
10. Fortunato G, Rubba P, Panico S, Trono D, Tinto N, Mazzaccara C et al. A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media thickness in middleaged women. Atherosclerosis 2003; 167: 141-148.
11. Harangi M, Seres I, Magyar MT, Csipo I, Sipka S, Valikovics A et al. Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease. Cerebrovasc Dis 2008; 25: 122-128.
12. Brinkley TE, Nicklas BJ, Kanaya AM, Satterfield S, Lakatta EG, Simonsick EM et al. Plasma oxidized lowdensity lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study. Hypertension 2009; 53: 846-852.