An unexpected ring contraction of two nitroaryl pro-drugs: conversion of N-(nitroaryl)-3-chloropiperidine derivatives into N-(nitroaryl)-2-chloromethylpyrrolidines

Tetrahedron Letters

Volumn 51, Issue 30, 2010, Pages 3918-3921

  Burke, Philip J ^a   Wong, Lai Chun ^b   Clegg, William ^c   Harrington, Ross W ^c   Jenkins, Terence C ^a   Knox, Richard J ^a   Meikle, Ian T ^b   Stanforth, Stephen P ^b  

^a Morvus Technology Limited   (United Kingdom)

^b NORTHUMBRIA UNIVERSITY   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Aziridinium ions; CB1954; NAD(P)H: quinone oxidoreductase 1; Nitroaromatic pro drugs; NQO1; SN 23862

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; AZIRIDINE DERIVATIVE; CHLOROMETHYL METHYL ETHER; NITROGEN DERIVATIVE; NQO 1; OXIDOREDUCTASE; PIPERIDINE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRROLIDINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SN 23862; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CROSS LINKING; DRUG STRUCTURE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 77953809477     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.05.095     Document Type: Article

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