Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma

Analytical and Bioanalytical Chemistry

Volumn 397, Issue 4, 2010, Pages 1605-1615

  Fortuna, Ana ^a,b   Sousa, Joana ^a,b   Alves, Gilberto ^b,c   Falcão, Amílcar ^a,b   Soares Da Silva, Patrício ^d  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^d DEPARTMENT OF RESEARCH AND DEVELOPMENT   (Portugal)

Author keywords

Bioanalytical method validation; Carbamazepine; Eslicarbazepine acetate; HPLC; Oxcarbazepine; Therapeutic drug monitoring

Indexed keywords

ANTIEPILEPTIC DRUGS; AQUEOUS MOBILE PHASE; BIOANALYTICAL METHODS; CARBAMAZEPINE; CONCENTRATION RANGES; FOOD AND DRUG ADMINISTRATION; HPLC-UV; HUMAN PLASMAS; MOBILE PHASE; OXCARBAZEPINE; SOLID-PHASE EXTRACTION; THERAPEUTIC DRUG MONITORING; ULTRA VIOLET DETECTION;

ACETONITRILE; BIOMOLECULES; CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METABOLITES; METHANOL; PATIENT MONITORING;

AMIDES;

10,11 DIHYDRO 10 HYDROXY 5H DIBENZ(B,F)AZEPINE 5 CARBOXAMIDE; 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ(B,F)AZEPINE-5-CARBOXAMIDE; CARBAMAZEPINE; CARBAMAZEPINE 10,11 OXIDE; DIBENZAZEPINE DERIVATIVE; DRUG DERIVATIVE; ESLICARBAZEPINE ACETATE; OXCARBAZEPINE;

ARTICLE; BLOOD; CHEMICAL STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; ULTRAVIOLET SPECTROPHOTOMETRY; VALIDATION STUDY;

CARBAMAZEPINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIBENZAZEPINES; HUMANS; MOLECULAR STRUCTURE; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM;

EID: 77953806616     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-010-3673-0     Document Type: Article

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