Antagonizing inhibition gets NK cells going

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 23, 2010, Pages 10333-10334

  Rajagopalan, Sumati ^a   Long, Eric O ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA C ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; RECEPTOR BLOCKING AGENT; T LYMPHOCYTE RECEPTOR;

AMINO ACID SEQUENCE; BINDING SITE; CELLULAR IMMUNITY; HUMAN; NATURAL KILLER CELL; NOTE; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN VARIANT; RECEPTOR BLOCKING; T LYMPHOCYTE;

HLA ANTIGENS; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; RECEPTORS, KIR; SIGNAL TRANSDUCTION;

EID: 77953781727     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1005636107     Document Type: Note

References (14)

1. Lanier LL (2005) NK cell recognition. Annu Rev Immunol 23:225-274.
2. Parham P (2005) MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol 5:201-214.
3. Kulkarni S, Martin MP, Carrington M (2008) The yin and yang of HLA and KIR in human disease. Semin Immunol 20:343-352.
4. Long EO (2008) Negative signaling by inhibitory receptors: The NK cell paradigm. Immunol Rev 224:70-84.
5. Long EO, Rajagopalan S (2000) HLA class I recognition by killer cell Ig-like receptors. Semin Immunol 12:101-108. (Pubitemid 30199274)
6. Fadda L, et al. (2010) Peptide antagonism as a mechanism for NK cell activation. Proc Natl Acad Sci USA 107:10160-10165.
7. Stefanova I, Dorfman JR, Tsukamoto M, Germain RN (2003) On the role of self-recognition in T cell responses to foreign antigen. Immunol Rev 191:97-106. (Pubitemid 36398851)
8. Sumen C, Dustin ML, Davis MM (2004) T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation. J Cell Biol 166:579-590. (Pubitemid 39097177)
9. Wylie DC, Das J, Chakraborty AK (2007) Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module. Proc Natl Acad Sci USA 104:5533-5538.
10. Boyington JC, Motyka SA, Schuck P, Brooks AG, Sun PD (2000) Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand. Nature 405:537-543.
11. FanQR, Long EO, Wiley DC (2001) Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nat Immunol 2:452-460.
12. Treanor B, et al. (2006) Microclusters of inhibitory killer immunoglobulin-like receptor signaling at natural killer cell immunological synapses. J Cell Biol 174: 153-161.
13. Yokoyama WM, Kim S (2006) Licensing of natural killer cells by self-major histocompatibility complex class I. Immunol Rev 214:143-154.
14. Joncker NT, Raulet DH (2008) Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells. Immunol Rev 224: 85-97.